ABCA4
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Official Full Name
ATP-binding cassette, sub-family A (ABC1), member 4
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Overview
ATP-binding cassette, sub-family A (ABC1), member 4, also known as ABCA4 or ABCR, is a protein which in humans is encoded by the ABCA4 gene. -
Synonyms
FFM;RMP;ABCR;RP19;STGD;ABC10;ARMD2;CORD3;STGD1;FLJ17534;DKFZp781N1972;retinal-specific ATP-binding cassette transporter;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ABCA4-033H | Recombinant Human ABCA4 Protein, GST-Tagged | Wheat Germ | GST |
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| Human | ABCA4-8115H | Recombinant Human ABCA4 protein, His & T7-tagged | E.coli | His/T7 | Gly1398~Asn1727 (Accession # P78363) |
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| Human | ABCA4-0607H | Recombinant Human ABCA4 Protein (Gly1398-Asn1727), N-His-tagged | E.coli | N-His | Gly1398-Asn1727 |
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| Mouse | ABCA4-1080M | Recombinant Mouse ABCA4 Protein | Mammalian Cell | His |
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| Mouse | ABCA4-182M-B | Recombinant Mouse ABCA4 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | ABCA4-182M | Recombinant Mouse ABCA4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ABCA4 Related Articles
ABCA4 involved in several pathways and played different roles in them. We selected most pathways ABCA4 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | TAP1;Abca2;ABCD3;ABCA1B;ABCD1;ABCA4;ABCB1LB;ABCB8;ABCC10 |
ABCA4 has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCA4 itself. We selected most functions ABCA4 had, and list some proteins which have the same functions with ABCA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PDPK1;UBE2J2;CNTN1B;PEO1;DDX17;ACTR1B;ABCG2C;SPHK1;PARS2 |
| ATPase activity | DQX1;ABCC1;KIF12;KIF14;PMS1;NSF;KIF9;KIF7;DNAH6 |
| ATPase activity, coupled to transmembrane movement of substances | ABCG5;ABCB6;ATP6V1D;ABCA13;ABCA7;ABCC3;ABCD2;Abca2;ABCB10 |
| cholesterol transporter activity | APOE;ABCA1;APOA4B.2;APOA5;STAR;APOA4B.1;APOA4;CETP;APOA1 |
| nucleotide binding | SAFB2;RALAA;EWSR1;ARL4AB;CLK2B;ARL3L1;NOL8;NT5C3A;SRSF2B |
| phospholipid transporter activity | APOA1;ABCA7;CETP;ABCA4A;OSBPL8;ABCA1;MFSD2AA;OSBPL5;MFSD2A |
| phospholipid-translocating ATPase activity | ATP8B5;ATP8A1;ATP11A;ABCA4;ATP10A;Atp8a2;ATP9B;ATP8B1;ATP11C |
| transporter activity | SLC13A5A;FABP6;SLCO1B2;CRABP1B;RBP1;GOSR2;FABP2;ATP5G3;PTGDSB |
ABCA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCA4.
- Q&As
- Reviews
Q&As (10)
Ask a questionOur recombinant ABCA4 proteins are produced in E. coli, Wheat Germ, or Mammalian Cell expression systems. And the product data sheet will provide you with specific information on how individual proteins were produced.
Our recombinant ABCA4 proteins have high purity and immunoreactivity, suitable for use as positive controls in, for example, ELISA, WB and other tests.
Creative BioMart offers coupons for each new customer and runs promotions on important holidays. Follow our website for the latest promotions.
Most recombinant proteins have a shelf life of one year. This guarantee is provided if they are kept under the optimal storage conditions described on the instruction. Please be careful to avoid repeated freezing and thawing.
Protein tags may or may not affect protein activity. For some applications, His tags may not affect protein activity and therefore need not be removed. However, protein tags are useful for affinity purification or for a variety of other purposes. If you are concerned about tags interfering with protein activity, Creative BioMart can also offer tag-free recombinant ABCA4 protein customization services.
Mutations in the ABCA4 gene have been found in patients with Stargardt disease. In addition, its mutation are also associated with cone-rod dystrophy type 3, retinitis pigmentosa-19, early-onset severe retinal dystrophy, macular degeneration age-related 2, and fundus flavimaculatus.
ABCA4 is expressed exclusively in retinal photoreceptor cells and mediates the transport of the essential molecule atRAL across the photoreceptor cell membrane.
ABCA4 protein has the molecular function of translocase and is involved in biological processes such as sensory transduction, transport and vision.
ABCA4 (ABCR, ARMD2, CORD3, FFM, RP19, STGD, STGD1).
Our ABCA4 protein products use His or GST tags.
Customer Reviews (3)
Write a reviewI purchased recombinant ABCA4 protein during the promotion. The price was very affordable and the product is of high quality and reliable, which saved me plenty of time and headaches.
Your recombinant ABCA4 protein has helped me make some progress in understanding the pathogenesis of macular degeneration.
I have been using your recombinant protein products and hope that the high quality standards and competitive prices will be maintained in the future.
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