ABHD4 Protein, abhydrolase domain containing 4

ABHD4

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ABHD4

Official Full Name abhydrolase domain containing 4
Background Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine.
Synonyms ABHD4; abhydrolase domain containing 4; abhydrolase domain-containing protein 4; FLJ12816; alpha/beta-hydrolase 4; lyso-N-acylphosphatidylethanolamine lipase; ABH4
    • Species :
    • Human
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ABHD4-078H Recombinant Human ABHD4 Protein, GST-Tagged Wheat Germ GST
    Human ABHD4-3337H Recombinant Human ABHD4, His tagged Insect Cell His
    Human ABHD4-675HCL Recombinant Human ABHD4 cell lysate Insect Cell N/A
    Rhesus Macaque ABHD4-191R Recombinant Rhesus monkey ABHD4 Protein, His-tagged Mammalian Cell His
    Zebrafish ABHD4-2384Z Recombinant Zebrafish ABHD4 Mammalian Cell His

    ABHD4 involved in several pathways and played different roles in them. We selected most pathways ABHD4 participated on our site, such as Glycerophospholipid biosynthesis, Hydrolysis of LPE, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABHD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycerophospholipid biosynthesis CHKA; CPNE6; ABHD3; SLC44A5B; AWAT2; CDS1; CHKB; PNPLA8; DGAT1B; AGPAT2
    Hydrolysis of LPE ABHD4
    Metabolism GPC5A; ETFA; PPM1K; SULT1C4; NFYAL; CYP27A1; FA2H; AMDHD1; HS3ST4; CEPT1A
    Metabolism of lipids and lipoproteins FAM213B; DHCR24; SREBF2; YAP1; ARSJ; STARD5; EBP; MED23; CYP8B2; ACOT11B
    Phospholipid metabolism PLBD1; SACM1L; CEPT1; PTPMT1; AWAT1; ABHD3; SACM1LB; SLC44A5B; ABHD4; SACM1LA

    ABHD4 has several biochemical functions, for example, carboxylic ester hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABHD4 itself. We selected most functions ABHD4 had, and list some proteins which have the same functions with ABHD4. You can find most of the proteins on our site.

    Function Related Protein
    carboxylic ester hydrolase activity AADACL2; Cel; FAM135B; CES1; NCEH1A; LIPCA; ACOT12; PNPLA7; ACOT6; Aadacl3

    ABHD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABHD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABHD4.

    TK1; CSNK2B

    Jebessa, ZH; Worst, B; et al. Protein Kinase A prevents cardiomyocyte hypertrophy through abhydrolase domain containing 5 (ABHD5)-mediated proteolysis of Histone deacetylase 4(HDAC4). CIRCULATION RESEARCH 113:-(2013).
    Demiralp, DO; Haznedaroglu, IC; et al. Functional proteomic analysis of Ankaferd (R) Blood Stopper. TURKISH JOURNAL OF HEMATOLOGY 27:70-77(2010).

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