acan
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  • Official Full Name
  • aggrecan
  • Background
  • This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ACAN; aggrecan; AGC1; SEDK; AGCAN; CSPG1; MSK16; CSPGCP; aggrecan core protein; large aggregating proteoglycan; cartilage-specific proteoglycan core protein; chondroitin sulfate proteoglycan core protein 1;
Cat.#:ACAN-102HTag:
Source (Host):NS0Species:Human
Product nameRecombinant Human ACAN, His-tagged
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Cat.#:ACAN-140HTag:GST
Source (Host):Wheat Germ (in vitro)Species:Human
Product nameRecombinant Human ACAN Protein, GST-Tagged
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Cat.#:ACAN-2888HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Aggrecan, Interglobular Domain, His-tagged
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Cat.#:ACAN-420HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ACAN Protein, GST-tagged
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Cat.#:ACAN-671HTag:His
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human ACAN Protein, His-tagged
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Cat.#:AGC-3238HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AGC, His-tagged, S tagged
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Cat.#:ACAN-1167MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ACAN Protein
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Cat.#:Acan-1956MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Acan protein, His-tagged
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Cat.#:Acan-1957RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Acan protein, His-tagged
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Cat.#:Acan-3239RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Acan, His-tagged
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Cat.#:ACAN-441RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ACAN Protein
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Cat.#:ACAN-6514CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ACAN
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Cat.#:ACAN-1955CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle ACAN protein, His & T7-tagged
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Cat.#:ACAN-35HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ACAN cell lysate
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Involved Pathway

ACAN involved in several pathways and played different roles in them. We selected most pathways ACAN participated on our site, such as Defective B4GALT1 causes B4GALT1-CDG (CDG-2d), Defective CHST6 causes MCDC1, Defective ST3GAL3 causes MCT12 and EIEE15, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACAN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
ACAN; KERA; FMOD; OGN; PRELP
Defective CHST6 causes MCDC1
PRELP; ACAN; OGN; FMOD; KERA
Defective ST3GAL3 causes MCT12 and EIEE15
FMOD; OGN; PRELP; ACAN; KERA
Degradation of the extracellular matrix
NID1; COL15A1B; ADAMTS5; MMP10; COL25A1; MGC174857; MGC174152; TLL1; MMP15; COL19A1
Disease
OPN1MW; RPL35; CCNC; RBP1; FDXR; OGN; TH1L; SSRP1; KPNA4; LRRFIP1
Diseases associated with glycosaminoglycan metabolism
OGN; KERA; FMOD; ACAN; PRELP
Diseases of glycosylation
ACAN; KERA; FMOD; PRELP; OGN
ECM proteoglycans
COL9A3; MATN1; PTPRS; DAG1; VCANB; BGNA; SPARC; MATN3B; DMP1; COMP

Protein Function

ACAN has several biochemical functions, for example, carbohydrate binding, extracellular matrix structural constituent, hyaluronic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACAN itself. We selected most functions ACAN had, and list some proteins which have the same functions with ACAN. You can find most of the proteins on our site.
Function
Related Protein
Function carbohydrate binding
Related Protein SFTPD; GFPT2; Cd209g; FCNA; SIGLEC6; KLRC2; KRT1; NOMO1; LGALS3; FCER2
Function extracellular matrix structural constituent
Related Protein COL4A3; ELNA; PXDN; ELN; KAL1; COL1A1; PRELP; COL11A1A; MUC5AC; TFPI2
Function hyaluronic acid binding
Related Protein C1QBP; NCAN; LAYN; KIAA1199; HYAL2; STAB2; HAPLN4; HAPLN1A; TNFAIP6; HAPLN2
Function metal ion binding
Related Protein NKD2A; LMO7B; BCL11BA; TRIM35-22; PARP12B; ZC3H11A; ADCY9; OAS2; PRDM16; VAV3
Function protein binding
Related Protein DEFB121; NONO; HACL1; ACTA1; MAP3K7; HDAC5; SH3RF1; SPP1; PLP1; HIP1

Interacting Protein

ACAN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACAN here. Most of them are supplied by our site. Hope this information will be useful for your research of ACAN.
PCOLCE

ACAN Related Articles

Li, J; Xie, ZG; et al. Calcitonin treatment is associated with less severe osteoarthritis and reduced toll-like receptor levels in a rat model. JOURNAL OF ORTHOPAEDIC SCIENCE 19:1019-1027(2014).
Zanotti, S; Canalis, E; et al. Interleukin 6 mediates selected effects of Notch in chondrocytes. OSTEOARTHRITIS AND CARTILAGE 21:1766-1773(2013).