Recombinant Human ACAN Protein, GST-Tagged

• Cat.No.: ACAN-140H
• Product Overview: Human ACAN full-length ORF ( AAH36445.1, 1 a.a. - 721 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 73.08 kDa
• AA Sequence: MAARLLRGSLRVLGGHRAPRQLPAA RCSHSGGEERLETPSAKKLTDIGIR RIFSPEHDIFRKSVRKFFQEEVIPH HSEWEKAGEVSREVWEKAGKQGLLG VNIAEHLGGIGGDLYSAAIVWEEQA YSNCSGPGFSIHSGIVMSYITNHGS EEQIKHFIPQMTAGKCIGAIAMTEP GAGSDLQGIKTNAKKDGSDWILNGS KVFISNGSLSDVVIVVAVTNHEAPS PAHGISLFLVENGMKGFIKGRKLHK MGLKAQDTAELFFEDIRLPASALLG EENKGFYYIMKELPQERLLIADVAI SASEFMFEETRNYVKQRKAFGKTVA HLQTVQHKLAELKTHICVTRAFVDN CLQLHEAKRLDSATACMAKYWASEL QNSVAYDCVQLHGGWGYMWEYPIAK AYVDARVQPIYGGTNEIMKELIARE IVFDK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ACAN aggrecan [ Homo sapiens ]
• Official Symbol: ACAN
• Synonyms: ACAN; aggrecan; AGC1, aggrecan 1 , chondroitin sulfate proteoglycan 1 , CSPG1, MSK16; aggrecan core protein; aggrecan proteoglycan; CSPGCP; large aggregating proteoglycan; cartilage-specific proteoglycan core protein; chondroitin sulfate proteoglycan core protein 1; AGC1; SEDK; AGCAN; CSPG1; MSK16
• Gene ID: 176
• mRNA Refseq: NM_001135
• Protein Refseq: NP_001126
• MIM: 155760
• UniProt ID: P16112