adamts3
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  • Official Full Name
  • ADAM metallopeptidase with thrombospondin type 1 motif, 3
  • Background
  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene is the major procollagen II N-propeptidase. A deficiency of this protein may be responsible for dermatosparaxis, a genetic defect of connective tissues. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ADAMTS3; ADAM metallopeptidase with thrombospondin type 1 motif, 3; ADAMTS-4; A disintegrin and metalloproteinase with thrombospondin motifs 3; ADAM-TS3; ADAMTS-3; PC II-NP; ADAM-TS 3; zinc metalloendopeptidase; procollagen II N-proteinase; procollagen II amino propeptide-processing enzyme; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 3;
Cat.#:ADAMTS3-3015HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ADAMTS3, His-tagged
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Cat.#:ADAMTS3-305HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADAMTS3 Protein, GST-tagged
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Cat.#:ADAMTS3-736HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ADAMTS3
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Cat.#:ADAMTS3-9389HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADAMTS3, His-tagged
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Cat.#:ADAMTS3-8392ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ADAMTS3
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Cat.#:ADAMTS3-9030HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ADAMTS3 293 Cell Lysate
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Involved Pathway

ADAMTS3 involved in several pathways and played different roles in them. We selected most pathways ADAMTS3 participated on our site, such as Collagen biosynthesis and modifying enzymes, Collagen formation, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Collagen biosynthesis and modifying enzymes
COL3A1; PCOLCEA; COL2A1; COL17A1A; COL17A1; TLDC2; COL8A1A; COL28A1; COL19A1; COL9A1B
Collagen formation
COL17A1; SERPINH1; COL5A3A; COL4A5; COL28A1A; BMP1; PPIB; COL25A1; TLL2; LEPRE1
Extracellular matrix organization
MFAP5; DMP1; COL4A5; CTS7; CEACAM1; CTSG; PRP; BMP1A; ADAMTS1; PPIB
Metabolism of proteins
CTSG; IGFBP5; CEACAM21; ARSF; PCSK1; HYOU1; NAPB; GZMH; CNIH3; CPA3
O-glycosylation of TSR domain-containing proteins
ADAMTS1; ADAMTS10; ADAMTSL5; ADAMTS13; SPON1; ADAMTS20; ADAMTSL3; ADAMTS18; B3GALTL; ADAMTS15
O-linked glycosylation
GALNT13; MUC21; GALNT6; SSPO; MUC15; ADAMTSL3; ADAMTS8; SPON1A; GALNTL2; THSD7A
Post-translational protein modification
SPON1A; NAPAB; SMC5; DNAJC24; CNIH2; RING1; GALNTL5; MUC1; DPAGT1; EID3

Protein Function

ADAMTS3 has several biochemical functions, for example, endopeptidase activity, heparin binding, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS3 itself. We selected most functions ADAMTS3 had, and list some proteins which have the same functions with ADAMTS3. You can find most of the proteins on our site.
Function
Related Protein
Function endopeptidase activity
Related Protein PSMA2; SENP3B; KLK1B1; TMEM59; PSMB7; KLK1B8; PSEN1; ACE; SENP5; APH1C
Function heparin binding
Related Protein FGFR4; TGFBR3; NDNF; NOV; FGFBP1; BMP7; SERPINA10; THBS3; HBEGF; VEGFB
Function metalloendopeptidase activity
Related Protein ADAM17A; ADAM10; ADAMTS1; ADAMDEC1; ADAMTS10; BMP1B; ZMPSTE24; ADAMTS7; TLL2; PAPPAA
Function protein binding
Related Protein TRIM21; FANCL; VPS26A; TMEM88; FLG; RPP38; DEFA6; KIF20B; FRMD7; UHRF2
Function zinc ion binding
Related Protein CAR3; ZNRF3; ADAM7; ZFP385C; MAP3K1; GATAD1; XIRP2; Alb; PCGF6; RORCA

ADAMTS3 Related Articles

Pyun, JA; Kim, S; et al. Genome-wide association studies and epistasis analyses of candidate genes related to age at menarche and age at natural menopause in a Korean population. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 21:522-529(2014).
Chaemsaithong, P; Madan, I; et al. Characterization of the myometrial transcriptome in women with an arrest of dilatation during labor. JOURNAL OF PERINATAL MEDICINE 41:665-681(2013).