adra2c
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  • Official Full Name
  • adrenergic, alpha-2C-, receptor
  • Background
  • Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
  • Synonyms
  • ADRA2C; adrenergic, alpha-2C-, receptor; ADRA2L2, ADRA2RL2; alpha-2C adrenergic receptor; ADRARL2; alpha-2CAR; alpha2-AR-C4; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; alpha-2C-adrenergic receptor; alpha-2 adrenergic receptor subtype C4; ADRA2L2; ADR
Cat.#:ADRA2C-1384MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ADRA2C Protein
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Cat.#:Adra2c-3334RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Adra2c, His-tagged
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Cat.#:ADRA2C-543RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ADRA2C Protein
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Cat.#:ADRA2C-11834ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ADRA2C
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Cat.#:ADRA2C-8999HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ADRA2C 293 Cell Lysate
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Cat.#:Kit-1039Tag:
Source (Host):Species:
Product nameLysozyme Activity Assay Kit (Fluorometric)
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Cat.#:Kit-2182Tag:
Source (Host):Species:
Product namecAMP ADRA2C CHO-K1 GPCR Assay Kit
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Cat.#:Kit-1111Tag:
Source (Host):Species:
Product nameLipolysis (Adipocyte) Colorimetric/Fluorometric Assay Kit
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Involved Pathway

ADRA2C involved in several pathways and played different roles in them. We selected most pathways ADRA2C participated on our site, such as Adrenaline signalling through Alpha-2 adrenergic receptor, Adrenaline,noradrenaline inhibits insulin secretion, Adrenoceptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRA2C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adrenaline signalling through Alpha-2 adrenergic receptor
ADRA2B; ADRA2A; ADRA2C
Adrenaline,noradrenaline inhibits insulin secretion
GNB5; ADRA2A; ADRA2C; GNB5B; ADCY6; GNB5A; GNB3A; GNB3B
Adrenoceptors
ADRB2; ADRA2C; ADRB3; ADRA2A; ADRA1D; ADRA2B; ADRA1B; ADRB1; ADRa1A
Amine ligand-binding receptors
ADRB2; DRD2; ADRB3; ADRB1; CHRM3; ADRA2C; ADRA2A; ADRA2B; DRD3; DRD1
Class A/1 (Rhodopsin-like receptors)
NPSR1; PROK2; INSL5; NPFF; GPR68; LPAR1; LPAR2B; FPR-RS3; AMCF-II; NMU
G alpha (i) signalling events
TAS2R7; CCL27; INSL5; OXGR1A.2; LPAR5A; CHRM2; RGS6; ADRA2B; SSTR1; CCR8
G alpha (z) signalling events
ADRA2C; ADRA2A; RGS20; ADRA2B; RGS19; RGS4; RGS17
GPCR downstream signaling
MLN; ADRA2C; OR52J3; OPN4.1; CHRM5; TAS2R7; OPN1MW; EDN3; CRHR2; FPR-RS4

Protein Function

ADRA2C has several biochemical functions, for example, alpha-2A adrenergic receptor binding, alpha2-adrenergic receptor activity, epinephrine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRA2C itself. We selected most functions ADRA2C had, and list some proteins which have the same functions with ADRA2C. You can find most of the proteins on our site.
Function
Related Protein
Function alpha-2A adrenergic receptor binding
Related Protein ADRB1; UCHL1; APLP1; ADRBK1; ADRA2C
Function alpha2-adrenergic receptor activity
Related Protein ADRA2A; ADRA2DA; ADRA2DB; ADRA2B; ADRA2C
Function epinephrine binding
Related Protein ADRB3; ADRB1; ADRA2B; ADRB3A; ADRB2A; ADRB2; ADRB3B; ADRA2A; ADRB2B; ADRA2C
Function protein binding
Related Protein CLIC3; SYNGR1; STK11; AREG; CISD2; THY1; KCNE4; C1QTNF1; WIPI2; GBF1
Function protein heterodimerization activity
Related Protein ITGB1; NKX2-5; BAX; ABTB2; SMC4; FLOT1; HIST3H2BB; STX1A; HIST1H2BE; IKBKG
Function protein homodimerization activity
Related Protein HMGCR; BNIP3; DRD2; RENBP; DMRT3; TCF3B; CAMK2G; PLEK; DMRTB1; HEXB

ADRA2C Related Articles

Millan, MJ; La Cour, CM; et al. S33138[N-[4-[2-[(3aS, 9bR)-8-cyano-1,3a, 4,9b-tetrahydro[1]-benzopyrano[3,4-c] pyrrol-2(3H)-yl)-ethyl]phenylacetamide], a preferential dopamine D-3 versus D-2 receptor antagonist and potential antipsychotic agent: I. Receptor-binding profile and functional actions at G-protein-coupled receptors. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 324:587-599(2008).
Vazquez, S; Mladovan, AG; et al. Human breast cell lines exhibit functional alpha(2)-adrenoceptors. CANCER CHEMOTHERAPY AND PHARMACOLOGY 58:50-61(2006).