AKAP4
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Official Full Name
A kinase (PRKA) anchor protein 4
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Overview
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. -
Synonyms
AKAP4; A kinase (PRKA) anchor protein 4; A-kinase anchor protein 4; A kinase anchor protein 82 kDa; AKAP82; cancer/testis antigen 99; CT99; Fsc1; hAKAP82; HI; p82; protein kinase A anchoring protein 4; testis specific gene HI; testis-specific gene HI; A-k;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- E.Coli or Yeast
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | AKAP4-16H | Recombinant Human AKAP4, GST-tagged | Wheat Germ | GST | ||
Human | AKAP4-2072H | Recombinant Human AKAP4 Protein (189-854 aa), His-tagged | E.coli | His | 189-854 aa | |
Human | AKAP4-109H | Recombinant Human AKAP4 Protein, His-tagged | E.coli | N-His | Gln189-Arg373 | |
Mouse | AKAP4-1478M | Recombinant Mouse AKAP4 Protein | Mammalian Cell | His | ||
Mouse | AKAP4-430M-B | Recombinant Mouse AKAP4 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | AKAP4-430M | Recombinant Mouse AKAP4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | Akap4-3028R | Recombinant Rat Akap4, His-tagged | E.Coli or Yeast | His | 847 | |
Rat | AKAP4-591R | Recombinant Rat AKAP4 Protein | Mammalian Cell | His | ||
Rat | AKAP4-247R | Recombinant Rat AKAP4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | AKAP4-247R-B | Recombinant Rat AKAP4 Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
AKAP4 involved in several pathways and played different roles in them. We selected most pathways AKAP4 participated on our site, such as G Protein Signaling Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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G Protein Signaling Pathways | AKAP8;GNG13B;AKAP7;Akap2;AKAP1;GNB5B;AKAP6;Akap3;AKAP13 |
AKAP4 has several biochemical functions, for example, protein kinase A binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP4 itself. We selected most functions AKAP4 had, and list some proteins which have the same functions with AKAP4. You can find most of the proteins on our site.
Function | Related Protein |
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protein kinase A binding | AKAP17A;DACT2;AKAP7;AKAP14;DACT3;AKAP6;NBEA;AKAP4;MYRIP |
AKAP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP4.
- Q&As
- Reviews
Q&As (19)
Ask a questionAKAP4 interacts with several other proteins within the fibrous sheath and the sperm tail. One of its key interactions is with AKAP3, another A-kinase anchor protein, forming a complex that plays a vital role in regulating sperm motility. AKAP4 also interacts with various kinases, such as PKA, as well as other structural and signaling proteins within the sperm tail.
As of now, there are no specific therapeutic interventions targeting AKAP4 for the treatment of male infertility. However, understanding the mechanisms by which AKAP4 regulates sperm motility and fertility may pave the way for potential future interventions and therapies aimed at improving sperm function in cases of asthenozoospermia. Further research is needed to explore the therapeutic potential of targeting AKAP4.
AKAP4 deficiency in sperm cells can lead to impaired sperm motility, specifically affecting the movement and function of the sperm tail. This can result in reduced or compromised fertility in males. The absence or dysfunction of AKAP4 can disrupt the proper organization and assembly of the fibrous sheath, which is crucial for the normal structure and function of the sperm tail required for successful fertilization.
While the main known function of AKAP4 is in sperm motility, there is emerging evidence suggesting potential roles of AKAP4 in other cellular processes. Recent studies have indicated its presence in non-sperm cells, such as certain types of cancer cells, where it may contribute to cell migration and invasiveness. Further research is needed to fully understand the extent of AKAP4's functions outside of sperm cells.
Given the role of AKAP4 in sperm motility and fertilization, it is possible that targeting AKAP4 could be explored as a potential contraceptive strategy. However, developing a specific method or intervention targeting AKAP4 for contraception is currently hypothetical and would require extensive research and development to ensure safety and efficacy.
While AKAP4 is associated with male infertility in some cases, it is currently not widely used as a biomarker for diagnosing or assessing male infertility. The diagnosis of infertility typically involves a comprehensive evaluation of various factors, including semen analysis (which includes assessing sperm motility), hormone levels, genetic testing, and other clinical parameters. More research is needed to determine the utility of AKAP4 as a specific biomarker for male infertility.
AKAP4 is a potential target for male contraceptive development. Disrupting or inhibiting the function of AKAP4 could impair the organization and function of the fibrous sheath, leading to reduced sperm motility and temporary or reversible infertility. However, further research is necessary to understand the potential side effects and long-term implications of targeting AKAP4 for male contraception.
AKAP4 interacts with several other proteins and molecules in sperm cells to regulate sperm motility. For example, AKAP4 interacts with PKA (protein kinase A), which is a key enzyme involved in phosphorylating and regulating the activity of various proteins in sperm cells. This interaction helps anchor PKA to the fibrous sheath and allows it to phosphorylate other proteins involved in sperm motility.
While AKAP4 has been studied extensively in the context of sperm motility and fertility, ongoing research continues to explore its intricate functions and potential therapeutic applications. Studies are investigating various aspects of AKAP4, such as its interactions with other proteins, its genetic variations and mutations in relation to infertility, and its potential as a target for male contraception development.
AKAP4 expression and activity in sperm cells can be regulated through various mechanisms. One important regulatory mechanism is post-translational modification, such as phosphorylation. Phosphorylation of AKAP4 can affect its interaction with other proteins and modulate its function in regulating sperm motility.
While the main role of AKAP4 is in sperm motility, there is evidence to suggest its involvement in other cellular processes as well. AKAP4 has been implicated in the regulation of cAMP signaling, which is a critical signaling pathway involved in various cellular functions. Beyond its role in sperm cells, AKAP4 expression has also been detected in other tissues, suggesting potential involvement in other cellular processes that are yet to be fully understood.
AKAP4 is regulated through a variety of mechanisms in sperm cells. One way it is regulated is through phosphorylation, where specific kinases add phosphate groups to AKAP4, influencing its interactions with other proteins and modulating its function. Studies have shown that protein kinase A (PKA) and other signaling molecules are involved in the phosphorylation and regulation of AKAP4.
Targeting AKAP4 for male contraception is a possibility, as it plays a significant role in sperm motility and fertilization. However, the development of a contraceptive method specifically targeting AKAP4 would require extensive research to ensure safety and efficacy. Additionally, finding a selective and reversible method to modulate AKAP4 activity without interfering with other essential cellular functions would be challenging. Nonetheless, AKAP4 remains an area of interest for researchers exploring novel contraceptive strategies.
AKAP4 mutations have been implicated in some cases of severe asthenozoospermia, a form of male infertility characterized by reduced sperm motility. These mutations can disrupt the proper assembly and function of the fibrous sheath, impairing sperm tail structure and motility. However, it is important to note that AKAP4 mutations are relatively rare and contribute to only a small proportion of male infertility cases.
Yes, genetic variations and polymorphisms have been identified in the AKAP4 gene. These variations can lead to structural changes or altered expression levels of AKAP4, potentially affecting sperm motility and fertility. However, the frequency and clinical significance of these genetic variations in relation to male infertility are still being studied and understood.
Yes, AKAP4 mutations can potentially cause infertility, specifically in cases of severe asthenozoospermia. When the structural or functional properties of the fibrous sheath, which relies on AKAP4, are compromised, sperm motility is severely affected, reducing the chances of successful fertilization. However, it's important to note that AKAP4 mutations are not a common cause of male infertility.
Due to the rarity of AKAP4 mutations as a cause of male infertility, specific genetic tests targeting AKAP4 are not commonly available. However, in cases where severe asthenozoospermia is suspected, comprehensive genetic testing or whole-exome sequencing may be used to identify potential mutations in genes, including AKAP4, that contribute to the condition.
AKAP4 expression is primarily found in sperm cells, where it is abundantly present in the fibrous sheath component of the sperm tail. However, there is evidence of low levels of AKAP4 expression in other tissues as well, such as the testes and certain regions of the brain. The significance of AKAP4 expression in these tissues and its potential roles outside of sperm cells are areas of ongoing research.
Yes, genetic mutations in AKAP4 have been identified in some cases of severe asthenozoospermia, a condition characterized by reduced sperm motility. These mutations can lead to abnormalities in the structure and function of the sperm tail, impairing its ability to move properly. However, such mutations are relatively rare compared to other genetic causes of male infertility.
Customer Reviews (4)
Write a reviewI am privileged to have access to such a high-quality product backed by reliable assistance, knowing that it will effectively address my experimental demands.
In summary, the AKAP4 protein's exceptional quality, coupled with the manufacturer's top-tier technical support, renders it a perfect fit for my research needs.
Their commitment to providing exceptional customer support highlights their unwavering commitment to customer satisfaction, providing a valuable resource that complements the use of the AKAP3 protein.
Their unparalleled expertise and dedication ensure that my concerns are resolved promptly and efficiently, fostering a productive and streamlined research process.
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