AKAP5
-
Official Full Name
A kinase (PRKA) anchor protein 5
-
Overview
AKAPs (A-kinase anchoring proteins), as their name implies, are a family of scaffolding proteins that bind regulatory subunits of Protein Kinase A (PKA) thus localizing PKA activity to distinct regions of the cell (1). Beyond a common amphipathic alpha he -
Synonyms
AKAP5; A kinase (PRKA) anchor protein 5; A-kinase anchor protein 5; AKAP75; AKAP79; AKAP-5; AKAP 79; A-kinase anchor protein 79 kDa; A-kinase anchor protein, 79kDa; A-kinase anchoring protein 75/79; cAMP-dependent protein kinase regulatory subunit II high;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | AKAP5-401H | Recombinant Human AKAP5 Protein, GST-tagged | Wheat Germ | GST | ||
Human | AKAP5-714H | Recombinant Human AKAP5 | Mammalian Cell | His | ||
Human | AKAP5-3030H | Recombinant Human AKAP5, His-tagged | E.Coli or Yeast | His | 427 | |
Human | AKAP5-23H | Recombinant Human AKAP5, His-tagged | HEK293 | His | ||
Human | AKAP5-8939HCL | Recombinant Human AKAP5 293 Cell Lysate | HEK293 | N/A | ||
Human | AKAP5-1349HF | Recombinant Full Length Human AKAP5 Protein, GST-tagged | In Vitro Cell Free System | GST | 427 amino acids | |
Human | AKAP5-2451H-B | Recombinant Human AKAP5 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | AKAP5-2451H | Recombinant Human AKAP5 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | AKAP5-1479M | Recombinant Mouse AKAP5 Protein | Mammalian Cell | His | ||
Mouse | Akap5-110M | Recombinant Mouse Akap5 Protein, His&GST-tagged | E.coli | N-His&GST | Met1-Gln161 | |
Mouse | AKAP5-431M-B | Recombinant Mouse AKAP5 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | AKAP5-431M | Recombinant Mouse AKAP5 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | Akap5-3029R | Recombinant Rat Akap5, His-tagged | E.Coli or Yeast | His | 714 |
- Involved Pathway
- Protein Function
- Interacting Protein
- AKAP5 Related Articles
AKAP5 involved in several pathways and played different roles in them. We selected most pathways AKAP5 participated on our site, such as Calcium signaling in the CD4+ TCR pathway, G Protein Signaling Pathways, Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Calcium signaling in the CD4+ TCR pathway | RCAN1;FKBP1A;RCAN2;POU2F1;CHP;AKAP5;CSF2;BATF3;JUNB |
G Protein Signaling Pathways | AKAP12;AKAP10;AKAP13;KCNJ3;Akap2;AKAP4;GNG13B;AKAP8;AKAP6 |
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity | HAND2;MYO6;NSFB;NSFA;GRIP1;CACNG3;CACNG2;PICK1;AKAP5 |
Integration of energy metabolism | MARCKSB;ARL2;GNG13A;AKAP5;KCNJ11;GNB5A;KCNS3;KCNS3A;KCNC2 |
Metabolism | COX6A1;CYP2A13;MED31;NUDT1;CETP;MED15;CYP4B1;NAMPT;GNG13B |
Neuronal System | CACNB4B;NSFA;KCND1;CACFD1;KCNJ1A.4;NCALDA;CHRNA3;KCNA2B;KCNN1A |
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | CHRNA5;CHRND;HAND2;NSFA;GRIP1;AKAP5;NSFB;PICK1;NCALDA |
AKAP5 has several biochemical functions, for example, G-protein coupled receptor binding, GABA receptor binding, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP5 itself. We selected most functions AKAP5 had, and list some proteins which have the same functions with AKAP5. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
G-protein coupled receptor binding | PYY;UCN2;CORT;GNAL;NMS;S1PR1;USP33;GNA15;NPFF |
GABA receptor binding | PLCL1;GABARAPA;PPP2CA;ARFGEF2;GABARAPL2;GABRG1;PLCL2;GABARAP;MAF1 |
actin binding | BCL7B;ABLIM3;PPP1R18;INO80;MTSS1LA;VMHCL;MYH9A;SNTB2;DST |
adenylate cyclase binding | AKAP5;CHRNA7;AKAP6;ADCYAP1R1;CALM1;CALM3;AKAP12;CALM2;ADRB2 |
cadherin binding | CTNNA3;FXYD5;OLFM4;TBC1D2;NEO1;TRPC4;Fert2;CDK5R1;AKAP5 |
calmodulin binding | ITPKB;EEA1;MKNK2;MYLK;SCN5A;MAPKAPK2B;EDF1;SPTAN1;MYH9 |
protein binding | WAS;C1orf51;RGS14;TP53;DNM1;MMP3;ITGB3B;VPS4A;TMEM123 |
protein complex binding | HTR2A;GNB2;SIX2;TULP3;BAG3;ANKRD54;CDH2;CEBPA;ABP1 |
protein domain specific binding | ARFIP2A;ODF1;CALM2;NEDD4;TBL1X;VAPA;VPS4A;DDX6;ANGEL1 |
protein kinase A binding | AKAP14;AKAP5;DACT3;Akap2;MYRIP;AKAP13;AKAP6;RPS3;AKAP12 |
protein kinase A regulatory subunit binding | AKAP5;KCNQ1;C2orf88;PRKACA;ACBD3;AKAP8;AKAP7;PJA2;AKAP9 |
protein kinase binding | PIH1D1;CALM;TEX14;CCNL1A;PTPRC;SNAP91;LCK;MAP2K3;CD36 |
protein phosphatase 2B binding | BAD;SLC9A1;AKAP1;MYOZ2;AKAP5;SOD1;ATP2B4;PPP3CB |
AKAP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP5.
PRKAR2A; PRKACA; PRKACB; Kcnj2; KCNJ2; RXFP1; MRPL43; DERL1; 2_aha_camp; 8-aha-camp; 8-aha-omethyladenosine; HSPA8; SUV39H1; SLC25A12
- Q&As
- Reviews
Q&As (17)
Ask a questionAt present, AKAP5 is not established as a specific diagnostic marker for any diseases. However, ongoing research may uncover its potential diagnostic utility in certain conditions where AKAP5 dysregulation or altered expression has been observed.
AKAP5 contains multiple structural domains that contribute to its function. It has a long N-terminal region rich in potential protein-protein interaction sites, including amphipathic helices and an isoleucine-arginine motif. It also has a central domain that binds to the regulatory subunits of PKA and a C-terminal domain responsible for anchoring AKAP5 to various cellular structures.
Apart from PKA, AKAP5 interacts with multiple other molecules involved in signaling pathways. It can bind and recruit various enzymes, ion channels, receptors, and cytoskeletal proteins to specific subcellular locations. Some notable interacting partners of AKAP5 include phosphodiesterases, protein phosphatase 2B (calcineurin), NMDA receptors, L-type calcium channels, and adenylyl cyclases.
Yes, AKAP5 can interact with various isoforms of PKA by binding to their regulatory subunits. This allows for selective targeting of different PKA holoenzymes to specific subcellular locations.
Currently, there are no specific drugs or compounds that target AKAP5 directly. However, researchers are actively investigating the development of small molecules or peptides that can selectively disrupt AKAP5 interactions or modulate its functions.
AKAP5 plays a role in calcium signaling by anchoring PKA and calcium-related enzymes or channels. It is involved in regulating calcium-induced release of neurotransmitters and modulating NMDA receptor-mediated calcium influx.
Yes, AKAP5 knockout animal models have been generated to study its functions. These models have provided valuable insights into the role of AKAP5 in synaptic transmission, synaptic plasticity, and behavior.
Yes, AKAP5 can be phosphorylated by various kinases, including PKA itself. Phosphorylation of AKAP5 can regulate its localization, protein-protein interactions, and activity.
Some studies have identified genetic variations in AKAP5 that are associated with increased susceptibility to certain psychiatric disorders, including schizophrenia and bipolar disorder. However, more research is needed to fully understand the impact of these genetic variations on disease development and progression.
AKAP5 binds to the regulatory subunits of PKA, bringing the enzyme into close proximity with its substrate molecules. This interaction allows PKA to phosphorylate specific target proteins and regulate their function within the localized signaling microdomain.
Some studies highlight the involvement of AKAP5 in specific diseases and disorders. For instance, alterations in AKAP5 localization and function have been implicated in schizophrenia, bipolar disorder, and alcohol addiction. However, further research is necessary to establish a clearer understanding of AKAP5's role in these conditions.
Yes, the expression of AKAP5 can be regulated during development and in response to different physiological conditions or stimuli. It is known to be developmentally regulated in the brain, with changes in its expression levels during critical periods of synaptic maturation and plasticity.
While AKAP5's functions have been extensively studied in neurons, recent research suggests potential roles in other cell types. For example, AKAP5 has been implicated in cardiac function, where it regulates the localization and activity of ion channels and receptors. However, further investigation is needed to fully understand AKAP5's functions outside of the nervous system.
Yes, AKAP5 is important for synaptic plasticity, which is the ability of synapses to strengthen or weaken in response to neuronal activity. It anchors PKA and other signaling molecules to postsynaptic densities, where they modulate neurotransmitter receptor function, synaptic strength, and long-term potentiation (LTP) or long-term depression (LTD) processes associated with synaptic plasticity.
AKAP5 is widely expressed in various tissues, including the brain, heart, and skeletal muscle. It is especially abundant in neurons, where it is involved in regulating neuronal signaling and synaptic plasticity.
AKAP5 can be regulated through multiple mechanisms. One important regulatory mechanism involves phosphorylation, where various kinases can target AKAP5 and modulate its activity or binding affinity for interacting proteins. Additionally, intracellular signaling pathways, calcium levels, and changes in subcellular localization can influence AKAP5 function and its interactions with other molecules.
Due to its vital role in regulating various cellular processes, including neuronal function, AKAP5 has been considered as a potential therapeutic target. Developing drugs or compounds that selectively modulate AKAP5 interactions or disrupt specific protein-protein interactions involving AKAP5 could provide a means to regulate neuronal signaling and potentially treat certain neurological disorders.
Customer Reviews (4)
Write a reviewThe AKAP5 protein stands as a pinnacle of quality, demonstrating exceptional purity and functionality that elegantly fulfills my experimental requirements.
Beyond the protein's outstanding attributes, the manufacturer's commitment to delivering excellent technical support is truly remarkable.
By utilizing the AKAP5 protein, I can confidently delve into my experiments, knowing that it will provide unparalleled precision and effectiveness.
Its superior composition ensures utmost reliability and accuracy in achieving my research objectives.
Ask a Question for All AKAP5 Products
Required fields are marked with *
My Review for All AKAP5 Products
Required fields are marked with *