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AKAP5

  • Official Full Name

    A kinase (PRKA) anchor protein 5

  • Overview

    AKAPs (A-kinase anchoring proteins), as their name implies, are a family of scaffolding proteins that bind regulatory subunits of Protein Kinase A (PKA) thus localizing PKA activity to distinct regions of the cell (1). Beyond a common amphipathic alpha he
  • Synonyms

    AKAP5; A kinase (PRKA) anchor protein 5; A-kinase anchor protein 5; AKAP75; AKAP79; AKAP-5; AKAP 79; A-kinase anchor protein 79 kDa; A-kinase anchor protein, 79kDa; A-kinase anchoring protein 75/79; cAMP-dependent protein kinase regulatory subunit II high;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AKAP5-401H Recombinant Human AKAP5 Protein, GST-tagged Wheat Germ GST
Human AKAP5-714H Recombinant Human AKAP5 Mammalian Cell His
Human AKAP5-3030H Recombinant Human AKAP5, His-tagged E.Coli or Yeast His 427
Human AKAP5-23H Recombinant Human AKAP5, His-tagged HEK293 His
Human AKAP5-8939HCL Recombinant Human AKAP5 293 Cell Lysate HEK293 N/A
Human AKAP5-1349HF Recombinant Full Length Human AKAP5 Protein, GST-tagged In Vitro Cell Free System GST 427 amino acids
Human AKAP5-2451H-B Recombinant Human AKAP5 Protein Pre-coupled Magnetic Beads HEK293
Human AKAP5-2451H Recombinant Human AKAP5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse AKAP5-1479M Recombinant Mouse AKAP5 Protein Mammalian Cell His
Mouse Akap5-110M Recombinant Mouse Akap5 Protein, His&GST-tagged E.coli N-His&GST Met1-Gln161
Mouse AKAP5-431M-B Recombinant Mouse AKAP5 Protein Pre-coupled Magnetic Beads HEK293
Mouse AKAP5-431M Recombinant Mouse AKAP5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Akap5-3029R Recombinant Rat Akap5, His-tagged E.Coli or Yeast His 714
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AKAP5 Related Articles

AKAP5 involved in several pathways and played different roles in them. We selected most pathways AKAP5 participated on our site, such as Calcium signaling in the CD4+ TCR pathway, G Protein Signaling Pathways, Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling in the CD4+ TCR pathwayRCAN1;FKBP1A;RCAN2;POU2F1;CHP;AKAP5;CSF2;BATF3;JUNB
G Protein Signaling PathwaysAKAP12;AKAP10;AKAP13;KCNJ3;Akap2;AKAP4;GNG13B;AKAP8;AKAP6
Glutamate Binding, Activation of AMPA Receptors and Synaptic PlasticityHAND2;MYO6;NSFB;NSFA;GRIP1;CACNG3;CACNG2;PICK1;AKAP5
Integration of energy metabolismMARCKSB;ARL2;GNG13A;AKAP5;KCNJ11;GNB5A;KCNS3;KCNS3A;KCNC2
MetabolismCOX6A1;CYP2A13;MED31;NUDT1;CETP;MED15;CYP4B1;NAMPT;GNG13B
Neuronal SystemCACNB4B;NSFA;KCND1;CACFD1;KCNJ1A.4;NCALDA;CHRNA3;KCNA2B;KCNN1A
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellCHRNA5;CHRND;HAND2;NSFA;GRIP1;AKAP5;NSFB;PICK1;NCALDA

AKAP5 has several biochemical functions, for example, G-protein coupled receptor binding, GABA receptor binding, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP5 itself. We selected most functions AKAP5 had, and list some proteins which have the same functions with AKAP5. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor bindingPYY;UCN2;CORT;GNAL;NMS;S1PR1;USP33;GNA15;NPFF
GABA receptor bindingPLCL1;GABARAPA;PPP2CA;ARFGEF2;GABARAPL2;GABRG1;PLCL2;GABARAP;MAF1
actin bindingBCL7B;ABLIM3;PPP1R18;INO80;MTSS1LA;VMHCL;MYH9A;SNTB2;DST
adenylate cyclase bindingAKAP5;CHRNA7;AKAP6;ADCYAP1R1;CALM1;CALM3;AKAP12;CALM2;ADRB2
cadherin bindingCTNNA3;FXYD5;OLFM4;TBC1D2;NEO1;TRPC4;Fert2;CDK5R1;AKAP5
calmodulin bindingITPKB;EEA1;MKNK2;MYLK;SCN5A;MAPKAPK2B;EDF1;SPTAN1;MYH9
protein bindingWAS;C1orf51;RGS14;TP53;DNM1;MMP3;ITGB3B;VPS4A;TMEM123
protein complex bindingHTR2A;GNB2;SIX2;TULP3;BAG3;ANKRD54;CDH2;CEBPA;ABP1
protein domain specific bindingARFIP2A;ODF1;CALM2;NEDD4;TBL1X;VAPA;VPS4A;DDX6;ANGEL1
protein kinase A bindingAKAP14;AKAP5;DACT3;Akap2;MYRIP;AKAP13;AKAP6;RPS3;AKAP12
protein kinase A regulatory subunit bindingAKAP5;KCNQ1;C2orf88;PRKACA;ACBD3;AKAP8;AKAP7;PJA2;AKAP9
protein kinase bindingPIH1D1;CALM;TEX14;CCNL1A;PTPRC;SNAP91;LCK;MAP2K3;CD36
protein phosphatase 2B bindingBAD;SLC9A1;AKAP1;MYOZ2;AKAP5;SOD1;ATP2B4;PPP3CB

AKAP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP5.

PRKAR2A; PRKACA; PRKACB; Kcnj2; KCNJ2; RXFP1; MRPL43; DERL1; 2_aha_camp; 8-aha-camp; 8-aha-omethyladenosine; HSPA8; SUV39H1; SLC25A12

Hong, GE; Kim, JA; et al. Flavonoids Identified from Korean Scutellaria baicalensis Georgi Inhibit Inflammatory Signaling by Suppressing Activation of NF-kappa B and MAPK in RAW 264.7 Cells. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE :-(2013).
Huang, ZH; Somanath, PR; et al. Changes in intracellular distribution and activity of protein phosphatase PP1 gamma 2 and its regulating proteins in spermatozoa lacking AKAP4. BIOLOGY OF REPRODUCTION 72:384-392(2005).
  • Q&As
  • Reviews

Q&As (17)

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Can AKAP5 be used as a diagnostic marker for any diseases? 08/04/2022

At present, AKAP5 is not established as a specific diagnostic marker for any diseases. However, ongoing research may uncover its potential diagnostic utility in certain conditions where AKAP5 dysregulation or altered expression has been observed.

What are the structural domains of AKAP5? 12/18/2021

AKAP5 contains multiple structural domains that contribute to its function. It has a long N-terminal region rich in potential protein-protein interaction sites, including amphipathic helices and an isoleucine-arginine motif. It also has a central domain that binds to the regulatory subunits of PKA and a C-terminal domain responsible for anchoring AKAP5 to various cellular structures.

Are there any other proteins or molecules that interact with AKAP5? 11/23/2021

Apart from PKA, AKAP5 interacts with multiple other molecules involved in signaling pathways. It can bind and recruit various enzymes, ion channels, receptors, and cytoskeletal proteins to specific subcellular locations. Some notable interacting partners of AKAP5 include phosphodiesterases, protein phosphatase 2B (calcineurin), NMDA receptors, L-type calcium channels, and adenylyl cyclases.

Can AKAP5 interact with multiple isoforms of PKA? 12/31/2020

Yes, AKAP5 can interact with various isoforms of PKA by binding to their regulatory subunits. This allows for selective targeting of different PKA holoenzymes to specific subcellular locations.

Are there any drugs or compounds that specifically target AKAP5? 05/06/2020

Currently, there are no specific drugs or compounds that target AKAP5 directly. However, researchers are actively investigating the development of small molecules or peptides that can selectively disrupt AKAP5 interactions or modulate its functions.

How is AKAP5 involved in calcium signaling? 12/27/2019

AKAP5 plays a role in calcium signaling by anchoring PKA and calcium-related enzymes or channels. It is involved in regulating calcium-induced release of neurotransmitters and modulating NMDA receptor-mediated calcium influx.

Are there any AKAP5 knockout (KO) animal models? 07/12/2019

Yes, AKAP5 knockout animal models have been generated to study its functions. These models have provided valuable insights into the role of AKAP5 in synaptic transmission, synaptic plasticity, and behavior.

Can AKAP5 be phosphorylated? 05/26/2019

Yes, AKAP5 can be phosphorylated by various kinases, including PKA itself. Phosphorylation of AKAP5 can regulate its localization, protein-protein interactions, and activity.

Does genetic variation in AKAP5 influence disease susceptibility? 02/04/2019

Some studies have identified genetic variations in AKAP5 that are associated with increased susceptibility to certain psychiatric disorders, including schizophrenia and bipolar disorder. However, more research is needed to fully understand the impact of these genetic variations on disease development and progression.

How does AKAP5 interact with PKA? 07/01/2018

AKAP5 binds to the regulatory subunits of PKA, bringing the enzyme into close proximity with its substrate molecules. This interaction allows PKA to phosphorylate specific target proteins and regulate their function within the localized signaling microdomain.

Is AKAP5 associated with any diseases or disorders? 08/19/2017

Some studies highlight the involvement of AKAP5 in specific diseases and disorders. For instance, alterations in AKAP5 localization and function have been implicated in schizophrenia, bipolar disorder, and alcohol addiction. However, further research is necessary to establish a clearer understanding of AKAP5's role in these conditions.

Is AKAP5 expression regulated during development? 06/25/2017

Yes, the expression of AKAP5 can be regulated during development and in response to different physiological conditions or stimuli. It is known to be developmentally regulated in the brain, with changes in its expression levels during critical periods of synaptic maturation and plasticity.

Does AKAP5 have any roles outside of neurons? 06/02/2016

While AKAP5's functions have been extensively studied in neurons, recent research suggests potential roles in other cell types. For example, AKAP5 has been implicated in cardiac function, where it regulates the localization and activity of ion channels and receptors. However, further investigation is needed to fully understand AKAP5's functions outside of the nervous system.

Does AKAP5 play a role in synaptic plasticity? 03/27/2016

Yes, AKAP5 is important for synaptic plasticity, which is the ability of synapses to strengthen or weaken in response to neuronal activity. It anchors PKA and other signaling molecules to postsynaptic densities, where they modulate neurotransmitter receptor function, synaptic strength, and long-term potentiation (LTP) or long-term depression (LTD) processes associated with synaptic plasticity.

Where is AKAP5 predominantly expressed? 03/11/2016

AKAP5 is widely expressed in various tissues, including the brain, heart, and skeletal muscle. It is especially abundant in neurons, where it is involved in regulating neuronal signaling and synaptic plasticity.

How is AKAP5 regulated in cells? 11/24/2015

AKAP5 can be regulated through multiple mechanisms. One important regulatory mechanism involves phosphorylation, where various kinases can target AKAP5 and modulate its activity or binding affinity for interacting proteins. Additionally, intracellular signaling pathways, calcium levels, and changes in subcellular localization can influence AKAP5 function and its interactions with other molecules.

Can AKAP5 be a potential therapeutic target? 03/09/2015

Due to its vital role in regulating various cellular processes, including neuronal function, AKAP5 has been considered as a potential therapeutic target. Developing drugs or compounds that selectively modulate AKAP5 interactions or disrupt specific protein-protein interactions involving AKAP5 could provide a means to regulate neuronal signaling and potentially treat certain neurological disorders.

Customer Reviews (4)

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Reviews
03/31/2022

    The AKAP5 protein stands as a pinnacle of quality, demonstrating exceptional purity and functionality that elegantly fulfills my experimental requirements.

    11/12/2020

      Beyond the protein's outstanding attributes, the manufacturer's commitment to delivering excellent technical support is truly remarkable.

      10/20/2020

        By utilizing the AKAP5 protein, I can confidently delve into my experiments, knowing that it will provide unparalleled precision and effectiveness.

        02/04/2018

          Its superior composition ensures utmost reliability and accuracy in achieving my research objectives.

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