aldob
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  • Official Full Name
  • aldolase B, fructose-bisphosphate
  • Background
  • Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related housekeeping genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.
  • Synonyms
  • ALDOB; aldolase B, fructose-bisphosphate; fructose-bisphosphate aldolase B; ALDB; ALDO B; ALDOB_HUMAN; Aldolase 2; Aldolase B; Aldolase B fructose bisphosphate; Aldolase2; AldolaseB; EC 4.1.2.13; Fructose bisphosphate aldolase B; Liver type aldolase; Liver-type aldolase; OTTHUMP00000021803; OTTHUMP00000021804; aldolase B, fructose-bisphosphatase; ALDO2
Cat.#:ALDOB-1325RTag:His
Source (Host):YeastSpecies:Rabbit
Product nameRecombinant Rabbit ALDOB Protein (2-364 aa), His-tagged
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Cat.#:ALDOB-326RTag:His|SUMO
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit ALDOB Protein (2-364 aa), His-SUMO-tagged
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Cat.#:ALDOB-1918HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Aldolase B, Fructose-Bisphosphate, His-tagged
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Cat.#:ALDOB-456HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ALDOB Protein, GST-tagged
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Cat.#:ALDOB-505HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDOB Protein, GST-tagged
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Cat.#:ALDOB-9567HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDOB, His-tagged
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Cat.#:ALDOB-1817CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ALDOB
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Cat.#:ALDOB-9718ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ALDOB
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Cat.#:ALDOB-8911HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ALDOB 293 Cell Lysate
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Involved Pathway

ALDOB involved in several pathways and played different roles in them. We selected most pathways ALDOB participated on our site, such as Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Fructose and mannose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDOB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycolysis / Gluconeogenesis
HK3; ALDOCA; PGAM1; PKM2; HK2; ALDOAA; FBP1; ENO1A; HKDC1; LDHC
Pentose phosphate pathway
PFKM; GPI; GPIA; DERA; ALDOA; G6PDX; ALDOC; FBP1B; GPIB; PRPS1A
Fructose and mannose metabolism
ALDOC; PFKM; PFKMB; PFKFB3; ALDOB; DHRS13L1; PFKMA; AKR1B8; AKR1B1; FBP1
Metabolic pathways
UGT1A9; LDHC; QDPRA; PGLS; PRIM1; SDS; CYP2J5; MAN2A2; MAT1A; ATP6V0D1
Carbon metabolism
PGK2; TPI1B; PFKMA; IDH2; MDH1AA; ACADS; TKTL2; AGXT; HAO1; SDHDB
Biosynthesis of amino acids
GLULA; RPE; ENO1A; PSPH; PCXB; PKMB; IDH1; AADAT; GOT2A; PKMA

Protein Function

ALDOB has several biochemical functions, for example, ATPase binding, cytoskeletal protein binding, fructose binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDOB itself. We selected most functions ALDOB had, and list some proteins which have the same functions with ALDOB. You can find most of the proteins on our site.
Function
Related Protein
Function ATPase binding
Related Protein ATP1B2; UBXN1; SNTA1; TCIRG1; S100A1; ATP1B1; PEX19; FXYD1; TAF9; ATP6V0A2
Function cytoskeletal protein binding
Related Protein RPH3AL; MYPN; CAPN10; Fert2; DYNLL2; MYLIP; DES; FLNC; PACSIN2; FRMD5
Function fructose binding
Related Protein PFKM; ALDOB; PFKL; ALDOA
Function fructose-1-phosphate aldolase activity
Related Protein ALDOB
Function fructose-bisphosphate aldolase activity
Related Protein ALDOB; ALDOAA; ALDOC; ALDOAB; ALDOCB; ALDOCA; ALDOA
Function identical protein binding
Related Protein TGFB3; KCNJ2; NOXO1; TRADD; TRIM55; PYDC3; CASC3; NFKB1; CLDN11; AMOTL2
Function phosphatidylcholine binding
Related Protein VPS24; RPE65; ALDOB; SERPINA5; NF1; APOA4B.2; CHMP2A; APOA2; GPR119; RASGRP1
Function protein binding
Related Protein LRRFIP2; MDFIC; CLOCKA; CBX4; LNPEP; COLGALT2; CIRH1A; FCRL2; GIP; RRAD

Interacting Protein

ALDOB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDOB here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDOB.
BBS7; BBS1; BBS4; BBS2; Slc12a1; HUS1; BUB1