| Description : |
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
39.3 kDa |
| AA Sequence : |
MAHRFPALTQEQKKELSEIAQSIVA NGKGILAADESVGTMGNRLQRIKVE NTEENRRQFREILFSVDSSINQSIG GVILFHETLYQKDSQGKLFRNILKE KGIVVGIKLDQGGAPLAGTNKETTI QGLDGLSERCAQYKKDGVDFGKWRA VLRIADQCPSSLAIQENANALARYA SICQQNGLVPIVEPEVIPDGDHDLE HCQYVTEKVLAAVYKALNDHHVYLE GTLLKPNMVTAGHACTKKYTPEQVA MATVTALHRTVPAAVPGICFLSGGM SEEDATLNLNAINLCPLPKPWKLSF SYGRALQASALAAWGGKAANKEATQ EAFMKRAMANCQAAKGQYVHTGSSG AASTQSLFTACYTYTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
