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ALKBH5

  • Official Full Name

    alkB, alkylation repair homolog 5 (E. coli)

  • Synonyms

    ALKBH5; alkB, alkylation repair homolog 5 (E. coli); OFOXD1, oxoglutarate and iron dependent oxygenase domain containing; probable alpha-ketoglutarate-dependent dioxygenase ABH5; FLJ20308; AlkB, alkylation repair homolog 5; OFOXD; OFOXD1; Oxoglutarate and iron-dependent oxygenase domain containing; alkylated DNA repair protein alkB homolog 5; ABH5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • In Vitro Cell Free System
  • Insect Cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ALKBH5-477H Recombinant Human ALKBH5 Protein, GST-tagged Wheat Germ GST
Human ALKBH5-8900HCL Recombinant Human ALKBH5 293 Cell Lysate HEK293 N/A
Human ALKBH5-32H Recombinant Human ALKBH5 Protein, Flag-tagged Insect Cells Flag
Human ALKBH5-1457HF Recombinant Full Length Human ALKBH5 Protein, GST-tagged In Vitro Cell Free System GST 458 amino acids
Mouse ALKBH5-1557M Recombinant Mouse ALKBH5 Protein Mammalian Cell His
Mouse ALKBH5-477M Recombinant Mouse ALKBH5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ALKBH5-477M-B Recombinant Mouse ALKBH5 Protein Pre-coupled Magnetic Beads HEK293
Rat ALKBH5-632R Recombinant Rat ALKBH5 Protein Mammalian Cell His
Rat ALKBH5-288R Recombinant Rat ALKBH5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ALKBH5-288R-B Recombinant Rat ALKBH5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ALKBH5-308R Recombinant Rhesus monkey ALKBH5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ALKBH5-136R-B Recombinant Rhesus Macaque ALKBH5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ALKBH5-136R Recombinant Rhesus Macaque ALKBH5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ALKBH5-4719Z Recombinant Zebrafish ALKBH5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ALKBH5 involved in several pathways and played different roles in them. We selected most pathways ALKBH5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ALKBH5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ALKBH5 has several biochemical functions, for example, metal ion binding, oxidative RNA demethylase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. Some of the functions are cooperated with other proteins, some of the functions could acted by ALKBH5 itself. We selected most functions ALKBH5 had, and list some proteins which have the same functions with ALKBH5. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingNR6A1B;CA15B;SIRT7;LMTK3;ZMYM2;FOLH1;CREB5;ZNF254;ZNF710
oxidative RNA demethylase activityALKBH5;FTO
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donorsC14orf169;EGLN2;P4HTM;EGLN1;KDM5BB;ALKBH8;KDM5BA;KDM5A;KDM5D
poly(A) RNA bindingDIAP1;DDX27;U2AF1;ARL6IP4;RALY;FTSJ3;HIST1H1E;HARS2;PCBP1

ALKBH5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALKBH5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALKBH5.

ssdna_dtdc; THOC7

  • Q&As
  • Reviews

Q&As (19)

Ask a question
What is the effect of ALKBH5 protein knockout on cell survival and metabolism? 03/28/2023

The knockout of ALKBH5 protein can significantly affect multiple biological processes such as cell survival, proliferation and apoptosis, indicating that ALKBH5 protein is necessary for normal physiological regulation of cells.

In what ways can ALKBH5 protein regulate gene expression and transcriptional modification? 03/25/2023

The protein can regulate gene expression and transcriptional modification through hybridization mutation and secondary structure change of m6A RNA modification.

How does the m6A demethylation mechanism of ALKBH5 protein work? 03/09/2023

This protein can recognize and bind to m6A RNA methylation modification, and then mediate m6A demethylation modification through active sites, thereby regulating metabolic transcription of target RNA.

What biological processes does ALKBH5 play an important role in? 03/05/2023

ALKBH5 plays an important role in RNA modification, metabolism and translation.

Does ALKBH5 participate in m6A modification? 02/02/2023

Yes, ALKBH5 is a protein involved in m6A modification.

What is the relationship between ALKBH5 protein and metabolic diseases? 08/06/2022

ALKBH5 protein is associated with metabolic diseases such as liver cancer and kidney disease, and its function of regulating metabolic balance is an important link in the occurrence and development of these diseases.

Does ALKBH5 protein have splicing isomers? What is the impact? 06/06/2022

ALKBH5 protein has a variety of splicing isomers, which have different functions and roles in interaction with other proteins and RNA modification.

What is the effect of ALKBH5 protein on tumorigenesis and development? 02/26/2022

ALKBH5 protein plays an important role in the metabolic process of tumors, so its abnormal expression and dysfunction can cause the occurrence and development of tumors.

In which tissues and cells is ALKBH5 protein highly expressed? 02/21/2022

ALKBH5 protein is highly expressed in reproductive organs, brain tissue, heart and other tissues and cells.

Is the expression of ALKBH5 protein affected by endogenous factors? What's the connection? 01/29/2022

The expression of ALKBH5 protein is affected by a variety of endogenous factors, such as hormone levels and metabolite concentrations, which are related to the function and regulation of ALKBH5 protein.

In which tissues is ALKBH5 expressed most frequently? 01/19/2022

ALKBH5 is frequently expressed in human ovary, testis and thyroid tissue.

Is ALKBH5 involved in human germ cell development? 10/25/2021

Yes, ALKBH5 is involved in human germ cell development and fertilization.

What are the interactions between ALKBH5 protein and other proteins? What's the biological significance? 01/29/2021

ALKBH5 interacts with proteins related to RNA modification, such as m6A methyltransferase and m6A reader protein, which have important biological significance for the stability and precise regulation of RNA modification.

Is there a specific drug targeted treatment plan for ALKBH5? 01/21/2021

At present, no specific drug targeting regimen for ALKBH5 has been identified.

Is there an ALKBH5 enhancer or inhibitor? 10/31/2020

No enhancers or inhibitors of ALKBH5 have been developed.

Does ALKBH5 need to bind to other proteins to perform its function? 06/11/2020

Yes, ALKBH5 usually needs to bind to other RNA-modified proteins to perform its functions.

Is the mutation of ALKBH5 gene associated with any diseases? 03/24/2020

No direct correlation has been found between mutations in ALKBH5 and specific diseases.

Does ALKBH5 participate in the genesis and progression of tumors? 02/02/2020

Some studies have suggested that ALKBH5 may have some effect on the development and progression of tumors.

What is the structure and function of ALKBH5 protein? 11/22/2019

The ALKBH5 protein is a protein that regulates RNA modification and mediates demethylation of m6A RNA methylation.

Customer Reviews (4)

Write a review
Reviews
06/07/2022

    Good stability and durability under the influence of temperature, humidity and light.

    01/25/2022

      ALKBH5 has good consistency and reliability.

      11/16/2019

        Immunogenic and allergenic, which is more important for proteins used in drug development.

        05/11/2019

          This protein does not elicit a response from the immune system.

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