ALKBH5
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Official Full Name
alkB, alkylation repair homolog 5 (E. coli)
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Synonyms
ALKBH5; alkB, alkylation repair homolog 5 (E. coli); OFOXD1, oxoglutarate and iron dependent oxygenase domain containing; probable alpha-ketoglutarate-dependent dioxygenase ABH5; FLJ20308; AlkB, alkylation repair homolog 5; OFOXD; OFOXD1; Oxoglutarate and iron-dependent oxygenase domain containing; alkylated DNA repair protein alkB homolog 5; ABH5;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- HEK293
- In Vitro Cell Free System
- Insect Cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ALKBH5 involved in several pathways and played different roles in them. We selected most pathways ALKBH5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ALKBH5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ALKBH5 has several biochemical functions, for example, metal ion binding, oxidative RNA demethylase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. Some of the functions are cooperated with other proteins, some of the functions could acted by ALKBH5 itself. We selected most functions ALKBH5 had, and list some proteins which have the same functions with ALKBH5. You can find most of the proteins on our site.
Function | Related Protein |
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metal ion binding | NR6A1B;CA15B;SIRT7;LMTK3;ZMYM2;FOLH1;CREB5;ZNF254;ZNF710 |
oxidative RNA demethylase activity | ALKBH5;FTO |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | C14orf169;EGLN2;P4HTM;EGLN1;KDM5BB;ALKBH8;KDM5BA;KDM5A;KDM5D |
poly(A) RNA binding | DIAP1;DDX27;U2AF1;ARL6IP4;RALY;FTSJ3;HIST1H1E;HARS2;PCBP1 |
ALKBH5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALKBH5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALKBH5.
ssdna_dtdc; THOC7
- Q&As
- Reviews
Q&As (19)
Ask a questionThe knockout of ALKBH5 protein can significantly affect multiple biological processes such as cell survival, proliferation and apoptosis, indicating that ALKBH5 protein is necessary for normal physiological regulation of cells.
The protein can regulate gene expression and transcriptional modification through hybridization mutation and secondary structure change of m6A RNA modification.
This protein can recognize and bind to m6A RNA methylation modification, and then mediate m6A demethylation modification through active sites, thereby regulating metabolic transcription of target RNA.
ALKBH5 plays an important role in RNA modification, metabolism and translation.
Yes, ALKBH5 is a protein involved in m6A modification.
ALKBH5 protein is associated with metabolic diseases such as liver cancer and kidney disease, and its function of regulating metabolic balance is an important link in the occurrence and development of these diseases.
ALKBH5 protein has a variety of splicing isomers, which have different functions and roles in interaction with other proteins and RNA modification.
ALKBH5 protein plays an important role in the metabolic process of tumors, so its abnormal expression and dysfunction can cause the occurrence and development of tumors.
ALKBH5 protein is highly expressed in reproductive organs, brain tissue, heart and other tissues and cells.
The expression of ALKBH5 protein is affected by a variety of endogenous factors, such as hormone levels and metabolite concentrations, which are related to the function and regulation of ALKBH5 protein.
ALKBH5 is frequently expressed in human ovary, testis and thyroid tissue.
Yes, ALKBH5 is involved in human germ cell development and fertilization.
ALKBH5 interacts with proteins related to RNA modification, such as m6A methyltransferase and m6A reader protein, which have important biological significance for the stability and precise regulation of RNA modification.
At present, no specific drug targeting regimen for ALKBH5 has been identified.
No enhancers or inhibitors of ALKBH5 have been developed.
Yes, ALKBH5 usually needs to bind to other RNA-modified proteins to perform its functions.
No direct correlation has been found between mutations in ALKBH5 and specific diseases.
Some studies have suggested that ALKBH5 may have some effect on the development and progression of tumors.
The ALKBH5 protein is a protein that regulates RNA modification and mediates demethylation of m6A RNA methylation.
Customer Reviews (4)
Write a reviewGood stability and durability under the influence of temperature, humidity and light.
ALKBH5 has good consistency and reliability.
Immunogenic and allergenic, which is more important for proteins used in drug development.
This protein does not elicit a response from the immune system.
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