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ALOX15

  • Official Full Name

    arachidonate 15-lipoxygenase

  • Overview

    Arachidonate 15-lipoxygenase is an enzyme that in humans is encoded by the ALOX15 gene.
  • Synonyms

    ALOX15; arachidonate 15-lipoxygenase; 15 LOX 1; 15-LOX; 15-lipooxygenase-1; arachidonate omega-6 lipoxygenase; 15LOX-1; 15-LOX-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • FLAG
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ALOX15-7892H Recombinant Human ALOX15 protein, His-tagged E.coli His Lys170~Leu312 (Accession # P16050)
Human ALOX15-485H Recombinant Human ALOX15 Protein, GST-tagged Wheat Germ GST
Human ALOX15-8897HCL Recombinant Human ALOX15 293 Cell Lysate HEK293 N/A
Human ALOX15-26020TH Recombinant Human ALOX15 Wheat Germ N/A 662 amino acids
Human ALOX15-4696H Recombinant Human ALOX15 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ALOX15-001H Recombinant Human ALOX15 Protein, FLAG-tagged Insect cells FLAG
Human ALOX15-324H-B Recombinant Human ALOX15 Protein Pre-coupled Magnetic Beads HEK293
Human ALOX15-3674H Recombinant Human ALOX15 protein, GST-tagged E.coli GST 130 - 230 aa
Human ALOX15-20HF Recombinant Full Length Human ALOX15 Protein In Vitro Cell Free System 662 amino acids
Human ALOX15-3375H Recombinant Human ALOX15 protein, His-tagged E.coli His 130 - 230 aa
Human ALOX15-1479HF Recombinant Full Length Human ALOX15 Protein, GST-tagged In Vitro Cell Free System GST 662 amino acids
Human ALOX15-644HFL Recombinant Full Length Human ALOX15 Protein, C-Flag-tagged Mammalian cells Flag
Human ALOX15-324H Recombinant Human ALOX15 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ALOX15-636R Recombinant Rat ALOX15 Protein Mammalian Cell His
Rat ALOX15-292R-B Recombinant Rat ALOX15 Protein Pre-coupled Magnetic Beads HEK293
Rat ALOX15-292R Recombinant Rat ALOX15 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ALOX15 involved in several pathways and played different roles in them. We selected most pathways ALOX15 participated on our site, such as Arachidonic acid metabolism, Linoleic acid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALOX15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arachidonic acid metabolismPLA2G2E;PTGES2;CYP2P8;FAM213B;CYP4B1;CYP2E1;PTGS1;CYP2J2;CYP4A12A
Linoleic acid metabolismCYP3A65;PLB1;CYP2C70;CYP2C37;PLA2G1B;ALOX15;PLA2G2A;PLA2G2D;PLA2G4F
Metabolic pathwaysACSS1;ALDH3A1;aLA;CMAS;NT5C1A;CYP11B1;NT5E;HK2;TYMP
Serotonergic synapsePRKACB;ALOX12;CYP2C38;PTGS2;GABRB1;PLCB4;HTR2B;RAF1;CYP4X1

ALOX15 has several biochemical functions, for example, arachidonate 12-lipoxygenase activity, arachidonate 15-lipoxygenase activity, eoxin A4 synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALOX15 itself. We selected most functions ALOX15 had, and list some proteins which have the same functions with ALOX15. You can find most of the proteins on our site.

Function Related Protein
arachidonate 12-lipoxygenase activityALOX12;ALOX15;ALOX12B;ALOX12E
arachidonate 15-lipoxygenase activityALOX15B;ALOX15;ALOX8
eoxin A4 synthase activity
hepoxilin A3 synthase activityALOX12;ALOX15
hepoxilin-epoxide hydrolase activityALOX15;ALOX12
iron ion bindingBRSK2;HBD;TET1;CYP2X7;CYP2B6;IRGM1;CYP2AD6;FTH1;BA1
phosphatidylinositol-4,5-bisphosphate bindingFCHO2;MARK1;AMER2;SNX18;CHMP3;ALOX15;PHLDA3;STXBP6;SNX20
protein bindingAGPAT5;JAM3;TOMM20;LPAR1;CHRNA5;TCF12;SZL;SERPINI2;KRTAP2-3

ALOX15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALOX15 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALOX15.

  • Q&As
  • Reviews

Q&As (14)

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In what way does ALOX15 regulate cell proliferation? 12/17/2022

It can regulate cell proliferation by regulating various cell signaling pathways and influencing cell cycle.

How does oxidative stress initiated by ALOX15 participate in immune response? 08/06/2022

The oxidative stress response initiated by ALOX15 can induce cells to secrete a variety of cytokines, thus participating in the immune response.

What is the effect of ALOX15 and GSTP1 gene variation on chemotherapy response of BLCA patients? 05/23/2022

ALOX15 and GSTP1 gene variants may affect how well BLCA patients respond to chemotherapy.

What effect does the loss of ALOX15 have on the body? 05/08/2022

ALOX15 deficiency may lead to a variety of effects such as alveolar hyperdilation, cardiomyopathy, and metabolic syndrome.

Which cell signaling pathways are involved in ALOX15? 04/11/2021

ALOX15 is involved in many cell signaling pathways, such as PI3K/AKT pathway, MAPK pathway, NF-κB pathway, etc.

What inflammatory reactions does ALOX15 participate in? 03/28/2021

ALOX15 is involved in a variety of inflammatory reactions, such as asthma, arthritis, and skin inflammation.

What is the role of ALOX15 in asthma? 03/05/2021

ALOX15 is involved in the pathogenesis of asthma, mediating airway stenosis and inflammation through the synthesis of leukotrienes.

What is the role of ALOX15 in tumorigenesis and development? 02/15/2021

The effects of ALOX15 vary in different tumor types, such as acting as an inhibitor in colorectal cancer and promoting tumor cell growth and invasion in prostate cancer.

How does ALOX15 regulate apoptosis? 12/11/2020

ALOX15 can affect apoptosis by regulating ROS levels and influencing cell signaling pathways.

What diseases do mutations in ALOX15 cause? 09/18/2020

Mutations in ALOX15 have been linked to diseases such as asthma and Behcet's disease.

What is the role of ALOX15 in neurodevelopment? 09/15/2020

This protein is involved in the process of neural development, such as promoting the growth of nerve cells and affecting brain development.

How does the oxidative stress response initiated by ALOX15 affect cell function? 09/07/2020

Oxidative stress response initiated by ALOX15 produces a large number of ROS, which affects various cell functions, such as apoptosis and cell proliferation.

In what diseases does ALOX15 play a role? 03/19/2020

It is involved in the pathogenesis of many diseases, such as asthma, rheumatoid arthritis, and skin inflammation.

What role does ALOX15 play in the function of keratinocytes? 12/17/2019

It is involved in various functions such as keratinocyte differentiation and cell cycle regulation.

Customer Reviews (4)

Write a review
Reviews
12/19/2022

    Good fluorescence and absorption properties.

    11/26/2021

      ALOX15 has good stability in different environments and is not easily degraded.

      08/26/2021

        The effects of the recombinant proteins on the pathogenesis of related diseases were evaluated by animal models or in vitro experiments and found to be very good.

        03/11/2021

          The catalytic activity of ALOX15 protein is very excellent, and it can efficiently promote the progress of chemical reactions, showing excellent catalytic performance.

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