ALOX15
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Official Full Name
arachidonate 15-lipoxygenase
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Overview
Arachidonate 15-lipoxygenase is an enzyme that in humans is encoded by the ALOX15 gene. -
Synonyms
ALOX15; arachidonate 15-lipoxygenase; 15 LOX 1; 15-LOX; 15-lipooxygenase-1; arachidonate omega-6 lipoxygenase; 15LOX-1; 15-LOX-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect cells
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- FLAG
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ALOX15 involved in several pathways and played different roles in them. We selected most pathways ALOX15 participated on our site, such as Arachidonic acid metabolism, Linoleic acid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALOX15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonic acid metabolism | GPX5;CYP4B1;ALOX5B.3;PTGES3A;PLA2G4AA;CYP2C38;PLA2G6;CBR3;GPX2 |
| Linoleic acid metabolism | PLA2G12A;PLB1;PLA2G6;PLA2G12B;PLA2G4C;ALOX15;CYP2C9;PLA2G5;PLA2G2A |
| Metabolic pathways | ACSBG1;ACOT2;PRODH2;NAT8L;ADH7;PI4KA;BCO1L;ATP5J;MTMR7A |
| Serotonergic synapse | CYP2C39;PTGS2;PRKACG;CYP2D9;PLCB2;HTR3B;GNG2;GNG3;GNB3 |
ALOX15 has several biochemical functions, for example, arachidonate 12-lipoxygenase activity, arachidonate 15-lipoxygenase activity, eoxin A4 synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALOX15 itself. We selected most functions ALOX15 had, and list some proteins which have the same functions with ALOX15. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| arachidonate 12-lipoxygenase activity | ALOX12B;ALOX12E;ALOX12;ALOX15 |
| arachidonate 15-lipoxygenase activity | ALOX15B;ALOX8;ALOX15 |
| eoxin A4 synthase activity | |
| hepoxilin A3 synthase activity | ALOX15;ALOX12 |
| hepoxilin-epoxide hydrolase activity | ALOX12;ALOX15 |
| iron ion binding | PLOD2;CYP1C1;TPH1;P4HA3;BRSK2;CYP17A1;CYP2X10.2;CYP46A1.2;CYP2AA1 |
| phosphatidylinositol-4,5-bisphosphate binding | JPH2;TWF2;ADAP2;FCHO2;KCNJ2;FAM123B;TIRAP;SESTD1;SCIN |
| protein binding | ENOX1;FAM19A1;ZBTB43;IK;RABAC1;RTN3;CTSZ;DMD;DPH3 |
ALOX15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALOX15 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALOX15.
- Q&As
- Reviews
Q&As (14)
Ask a questionIt can regulate cell proliferation by regulating various cell signaling pathways and influencing cell cycle.
The oxidative stress response initiated by ALOX15 can induce cells to secrete a variety of cytokines, thus participating in the immune response.
ALOX15 and GSTP1 gene variants may affect how well BLCA patients respond to chemotherapy.
ALOX15 deficiency may lead to a variety of effects such as alveolar hyperdilation, cardiomyopathy, and metabolic syndrome.
ALOX15 is involved in many cell signaling pathways, such as PI3K/AKT pathway, MAPK pathway, NF-κB pathway, etc.
ALOX15 is involved in a variety of inflammatory reactions, such as asthma, arthritis, and skin inflammation.
ALOX15 is involved in the pathogenesis of asthma, mediating airway stenosis and inflammation through the synthesis of leukotrienes.
The effects of ALOX15 vary in different tumor types, such as acting as an inhibitor in colorectal cancer and promoting tumor cell growth and invasion in prostate cancer.
ALOX15 can affect apoptosis by regulating ROS levels and influencing cell signaling pathways.
Mutations in ALOX15 have been linked to diseases such as asthma and Behcet's disease.
This protein is involved in the process of neural development, such as promoting the growth of nerve cells and affecting brain development.
Oxidative stress response initiated by ALOX15 produces a large number of ROS, which affects various cell functions, such as apoptosis and cell proliferation.
It is involved in the pathogenesis of many diseases, such as asthma, rheumatoid arthritis, and skin inflammation.
It is involved in various functions such as keratinocyte differentiation and cell cycle regulation.
Customer Reviews (4)
Write a reviewGood fluorescence and absorption properties.
ALOX15 has good stability in different environments and is not easily degraded.
The effects of the recombinant proteins on the pathogenesis of related diseases were evaluated by animal models or in vitro experiments and found to be very good.
The catalytic activity of ALOX15 protein is very excellent, and it can efficiently promote the progress of chemical reactions, showing excellent catalytic performance.
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