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ALT

  • ALT Related Articles

ALT involved in several pathways and played different roles in them. We selected most pathways ALT participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ALT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ALT has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ALT itself. We selected most functions ALT had, and list some proteins which have the same functions with ALT. You can find most of the proteins on our site.

Function Related Protein

ALT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALT here. Most of them are supplied by our site. Hope this information will be useful for your research of ALT.

Chang, MS; Tuomala, R; et al. Postpartum care for mothers diagnosed with hepatitis B during pregnancy. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 212:-(2015).
Ronis, MJJ; Mercer, KE; et al. Increased 4-hydroxynonenal protein adducts in male GSTA4-4/PPAR-alpha double knockout mice enhance injury during early stages of alcoholic liver disease. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 308:G403-G415(2015).
  • Q&As
  • Reviews

Q&As (10)

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How is ALT expression regulated at the transcriptional and post-translational levels, and what signaling pathways or factors influence its expression? 09/01/2022

ALT expression is regulated by transcription factors, epigenetic modifications, and signaling pathways, such as Wnt/尾-catenin, MYC, or TGF-尾 signaling, providing insights into its regulation under different cellular conditions.

How does ALT interact with other proteins or macromolecules in the cell, and what are the functional consequences of these interactions? 07/16/2022

ALT interacts with various proteins, including transcription factors, chromatin remodelers, and co-regulators, influencing gene expression, DNA repair, or chromatin organization.

What are the physiological functions of ALT in cellular processes, such as metabolism, cell cycle regulation, or cellular stress responses? 05/01/2022

ALT plays essential roles in telomere maintenance, cellular senescence, telomere recombination, and alternative lengthening of telomeres (ALT) pathway activation.

What are the post-translational modifications that occur on ALT and how do they impact its activity, stability, or cellular localization? 08/16/2021

ALT undergoes post-translational modifications, including phosphorylation, acetylation, and SUMOylation, which can modulate its activity, stability, and recruitment to telomeres or subcellular compartments.

Can the enzymatic activity of ALT be characterized, and what are its potential substrates or metabolic pathways it participates in? 12/16/2020

ALT exhibits enzymatic activity as a DNA-dependent RNA polymerase, catalyzing the synthesis of RNA from a DNA template, but its specific substrates and metabolic pathways are still being elucidated.

Can genetic or epigenetic alterations in ALT be identified, and what are their implications for cellular function and disease development? 07/05/2019

Genetic alterations in ALT-related genes or mutations affecting telomere maintenance components are linked to telomere dysfunction disorders or predisposition to cancer development.

Can therapeutic strategies targeting ALT or its associated pathways offer potential interventions for diseases or conditions influenced by ALT dysregulation? 05/24/2019

Therapeutic strategies targeting ALT or its associated pathways may hold potential for cancer therapy by exploiting ALT activation as a vulnerability or developing specific inhibitors to disrupt ALT activity and telomere maintenance in cancer cells.

How does ALT contribute to specific disease processes, and what are the underlying mechanisms involved? 07/06/2018

Dysregulation of ALT has been implicated in various diseases, including cancer, where ALT activation is associated with telomere maintenance and genomic instability.

What are the structural features of ALT and how do they relate to its biological function and interaction with other molecules? 11/01/2017

Structural studies have revealed key domains in ALT, such as the reverse transcriptase domain, telomerase essential N-terminal (TEN) domain, and RNA-binding motifs, providing insights into its function and catalytic mechanism.

What is the subcellular localization of ALT and how does it distribute within different cellular compartments? 04/12/2017

ALT is primarily localized in the nucleus, but it can also be found in the cytoplasm and other cellular compartments, depending on the cell type and context.

Customer Reviews (3)

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Reviews
04/12/2022

    Convenient and efficient protein labeling options.

    09/04/2020

      Reduced nonspecific binding for cleaner data interpretation.

      06/11/2017

        Excellent resolution in protein separation techniques.

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