Alanine Transaminase Assay Kit
Cat.No. : | Kit-0082 |
Product Overview : | Detection and Quantification of Alanine Transaminase Activity. |
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- Gene Information
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Applications : | Functional Assay |
Storage : | Shipped and store at 4°C for 6 months. |
Products Types
◆ Recombinant Protein | ||
ALT-116 | Recombinant ALT protein, His-tagged | +Inquiry |
◆ Assay kits | ||
Kit-0083 | ALT Assay Kit | +Inquiry |
Kit-2209 | Alanine Aminotransferase Activity Colorimetric/Fluorometric Assay Kit | +Inquiry |
Kit-0084 | ALT Fluorometric Assay Kit | +Inquiry |
Not For Human Consumption!
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Customer Reviews (3)
Write a reviewConvenient and efficient protein labeling options.
Reduced nonspecific binding for cleaner data interpretation.
Excellent resolution in protein separation techniques.
Q&As (10)
Ask a questionALT expression is regulated by transcription factors, epigenetic modifications, and signaling pathways, such as Wnt/尾-catenin, MYC, or TGF-尾 signaling, providing insights into its regulation under different cellular conditions.
ALT interacts with various proteins, including transcription factors, chromatin remodelers, and co-regulators, influencing gene expression, DNA repair, or chromatin organization.
ALT plays essential roles in telomere maintenance, cellular senescence, telomere recombination, and alternative lengthening of telomeres (ALT) pathway activation.
ALT undergoes post-translational modifications, including phosphorylation, acetylation, and SUMOylation, which can modulate its activity, stability, and recruitment to telomeres or subcellular compartments.
ALT exhibits enzymatic activity as a DNA-dependent RNA polymerase, catalyzing the synthesis of RNA from a DNA template, but its specific substrates and metabolic pathways are still being elucidated.
Genetic alterations in ALT-related genes or mutations affecting telomere maintenance components are linked to telomere dysfunction disorders or predisposition to cancer development.
Therapeutic strategies targeting ALT or its associated pathways may hold potential for cancer therapy by exploiting ALT activation as a vulnerability or developing specific inhibitors to disrupt ALT activity and telomere maintenance in cancer cells.
Dysregulation of ALT has been implicated in various diseases, including cancer, where ALT activation is associated with telomere maintenance and genomic instability.
Structural studies have revealed key domains in ALT, such as the reverse transcriptase domain, telomerase essential N-terminal (TEN) domain, and RNA-binding motifs, providing insights into its function and catalytic mechanism.
ALT is primarily localized in the nucleus, but it can also be found in the cytoplasm and other cellular compartments, depending on the cell type and context.
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