AMIGO1
-
Official Full Name
adhesion molecule with Ig-like domain 1
-
Synonyms
AMIGO1;adhesion molecule with Ig-like domain 1;20824;ENSG00000181754;AMIGO;AMIGO-1;1p13.3;amphoterin-induced protein 1;amphoterin-induced protein 1;alivin-2;amphoterin-induced gene and ORF;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- AMIGO1 Related Articles
AMIGO1 involved in several pathways and played different roles in them. We selected most pathways AMIGO1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AMIGO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
AMIGO1 has several biochemical functions, for example, potassium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AMIGO1 itself. We selected most functions AMIGO1 had, and list some proteins which have the same functions with AMIGO1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| potassium channel regulator activity | KCNAB1;KCNIP2;ANK2;NEDD4L;ARPP19A;ARPP19;KCNMB2;KCNE2;KCNE1L |
AMIGO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMIGO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AMIGO1.
- Q&As
- Reviews
Q&As (10)
Ask a questionAMIGO1 plays a critical role in promoting neurite outgrowth and axon guidance by regulating cytoskeletal dynamics and signaling pathways involved in axonal growth cone guidance.
AMIGO1 interacts with various binding partners, including cell adhesion molecules and ion channels, through both homophilic and heterophilic interactions, contributing to neuronal cell-cell communication and synaptic connectivity.
During neuronal development, AMIGO1 undergoes dynamic changes in its subcellular localization, transitioning from a primarily intracellular distribution to a more plasma membrane-associated localization.
AMIGO1 has been implicated in the regulation of neuronal migration during brain development, particularly in the formation of cortical layers and the establishment of neuronal circuitry.
AMIGO1 exerts a neuroprotective effect by promoting neuronal survival and inhibiting apoptosis through the activation of intracellular signaling pathways that regulate cell survival and anti-apoptotic factors.
AMIGO1 is involved in myelination processes and oligodendrocyte development, promoting the differentiation and maturation of oligodendrocytes and facilitating proper myelin sheath formation.
AMIGO1 shows a distinct tissue-specific expression pattern, with high expression in the brain, particularly in the developing and mature neurons, as well as in other organs such as the heart, kidney, and lung.
AMIGO1 has been shown to modulate synaptic plasticity by regulating the surface expression of neurotransmitter receptors and modulating synaptic strength and connectivity.
Altered expression or dysregulation of AMIGO1 has been associated with various neurological disorders, including epilepsy, schizophrenia, and autism spectrum disorders, suggesting its potential involvement in disease pathogenesis.
Modulation of AMIGO1 expression or activity represents a potential therapeutic target for neurological conditions, and further studies investigating the specific mechanisms and downstream signaling pathways regulated by AMIGO1 may unveil novel therapeutic strategies for these disorders.
Customer Reviews (3)
Write a reviewSensitivity in detecting low-abundance proteins.
Specific target detection in various tissue types.
Robust assay performance in high-throughput screening.
Ask a Question for All AMIGO1 Products
Required fields are marked with *
My Review for All AMIGO1 Products
Required fields are marked with *
