ANO6
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Official Full Name
anoctamin 6
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Overview
This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ANO6; anoctamin 6; TMEM16F, transmembrane protein 16F; anoctamin-6; DKFZp313M0720; transmembrane protein 16F; SCTS; BDPLT7; TMEM16F; MGC104751;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ANO6-9683H | Recombinant Human ANO6, GST-tagged | E.coli | GST | 1-294a.a. | |
Human | ANO6-340H | Recombinant Human ANO6 Protein, His-tagged | E.coli | His | Ala744~Asn824 | |
Mouse | Ano6-5556M | Recombinant Mouse Ano6 Protein (Ala745-Asn825), C-Fc tagged | Mammalian cells | C-Fc | Ala745-Asn825 | |
Mouse | Ano6-5557M | Recombinant Mouse Ano6 Protein (Ala318-Asn398), C-His tagged | E.coli | C-His | Ala318-Asn398 | |
Mouse | Ano6-5558M | Recombinant Mouse Ano6 Protein (Ala745-Asn825), C-His tagged | Mammalian cells | C-His | Ala745-Asn825 |
- Involved Pathway
- Protein Function
- Interacting Protein
ANO6 involved in several pathways and played different roles in them. We selected most pathways ANO6 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANO6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Ion channel transport | BSND;OSTM1;TRPA1A;SRI;ANO5B;MCOLN2;ANO1;TRPC4A;CLCN2 |
Stimuli-sensing channels | NHEDC1;SLC9B2;TRPC4A;CLCN5;CLCN4;OSTM1;TRPV3;ANO10A;TRPC4APA |
Transmembrane transport of small molecules | SLC12A7;CLCNKA;SLC14A1;SLC7A11;SLC38A4;SLC20A1B;SLC6A11;PDZD11;SLC6A20 |
ANO6 has several biochemical functions, for example, calcium activated cation channel activity, NOT intracellular calcium activated chloride channel activity, intracellular calcium activated chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ANO6 itself. We selected most functions ANO6 had, and list some proteins which have the same functions with ANO6. You can find most of the proteins on our site.
Function | Related Protein |
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calcium activated cation channel activity | ANO10;TMEM63C;TRPM4;PKD2L1;CATSPER1;ANO6;CALHM1;TRPM4C;TRPM5 |
NOT intracellular calcium activated chloride channel activity | ANO8;ANO9;ANO10;Ano3;ANO7;ANO6;ANO5 |
intracellular calcium activated chloride channel activity | TTYH3;CLCA2;ANO4;NMUR2;ANO7;CLCA1;ANO9;ANO2;CLCA4 |
phospholipid scramblase activity | ANO9;ANO4;ANO6;PLSCR4;Ano3;PLSCR3B;PLSCR3A;PLSCR1;ANO7 |
protein binding | TRPC2;SNX27;COASY;PPP1R3C;EPS15;GPR85;HIST1H4G;RNF34;DCTN5 |
protein homodimerization activity | OXA1L;B4GALT1;ADRB3;DNTTIP1;TERT;CIB2;STUB1;CBX5;Fzd4 |
voltage-gated chloride channel activity | CLCN4-2;CLCNK;CLCN7;CLCN3;CLCN6;CLCN5;ANO6;CLCNKA;CLCN1A |
voltage-gated ion channel activity | KCNG4A;ANO6;KCNJ16;KCNIP1;KCNIP4;KCNV2B;CLCNKB;KCNJ1A.4;CLIC5A |
ANO6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANO6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANO6.
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- Q&As
- Reviews
Q&As (12)
Ask a questionANO6 protein has been shown to play a role in calcium-activated phospholipid scrambling, a process in which phospholipids are redistributed between the leaflets of the cell membrane. This process is important for maintaining membrane asymmetry, regulating blood clotting, and mediating apoptotic cell clearance. ANO6 acts as a calcium-activated scramblase, facilitating the movement of phospholipids across the bilayer by creating transient pores. The exact mechanism by which ANO6 accomplishes this is not fully understood, but it is thought to involve conformational changes in the protein triggered by calcium binding. Defects in ANO6-mediated phospholipid scrambling have been associated with Scott syndrome, a rare bleeding disorder.
There is potential for genetic manipulation of ANO6 protein to be used for therapeutic purposes. For instance, gene therapy approaches could be explored to correct ANO6 mutations associated with Scott syndrome or other diseases. This could involve introducing corrected copies of the ANO6 gene into affected cells or tissues to restore proper ANO6 protein function.
As of my current knowledge, there are no ongoing clinical trials specifically targeting ANO6 protein. However, research in this field is continuously evolving, and it is possible that clinical trials may be initiated in the future to evaluate the therapeutic potential of targeting ANO6 in various diseases. It is important to regularly check reputable clinical trial databases and scientific literature for the most up-to-date information on ongoing studies targeting ANO6 protein.
Dysregulation of ANO6 protein has been associated with several diseases. Mutations in the ANO6 gene have been linked to Scott syndrome, a rare bleeding disorder characterized by defective phospholipid scrambling and impaired blood clotting. ANO6 expression and activity have also been implicated in various other conditions, including cystic fibrosis, hypertension, cancer, and neuronal disorders.
Due to its involvement in various physiological processes and its dysregulation in certain diseases, ANO6 has emerged as a potential therapeutic target. Modulation of ANO6 activity could have implications in the treatment of disorders associated with abnormal calcium signaling, such as cystic fibrosis, asthma, or cardiovascular diseases. However, further research is needed to better understand ANO6's role in these conditions and to develop specific therapies targeting this protein.
Dysfunctional ANO6 protein has been associated with several diseases and conditions. Mutations in the ANO6 gene can lead to Scott syndrome, a bleeding disorder characterized by impaired blood coagulation. ANO6 has also been implicated in other pathological conditions such as inflammatory bowel disease, cancer, and neurodegenerative disorders; however, further research is needed to fully understand its role in these conditions.
Several compounds have been identified as modulators of ANO6 protein function. Examples include the activators T16A[inh]-A01 and Eact, as well as the inhibitor CaCCinh-A01. These compounds have been used in research to study ANO6 function and may have potential therapeutic applications.
As of now, there are no registered clinical trials specifically focused on ANO6 protein. However, research on ANO6 is ongoing, and it is possible that future studies may identify potential therapeutic applications and lead to clinical trials involving ANO6 or related compounds.
There are currently no specific inhibitors or activators of ANO6 protein available for clinical use. Developing selective compounds that modulate ANO6 activity is an active area of research, as such compounds could potentially be used for therapeutic purposes.
ANO6 protein activity can be regulated by various factors. One important mechanism is its regulation by calcium ions. ANO6 is a calcium-activated chloride channel, meaning its activity increases in the presence of intracellular calcium. This calcium dependence allows ANO6 to participate in calcium signaling pathways and respond to cellular cues. Other regulatory mechanisms may involve post-translational modifications, protein interactions, or regulatory subunits, though the specific details of these mechanisms are still being investigated.
Yes, ANO6 protein has emerged as a potential therapeutic target for various diseases. For example, in the context of cystic fibrosis, ANO6 has been suggested as a potential target for pharmacological intervention to enhance chloride secretion. Modulating ANO6 function could help restore proper ion transport and alleviate symptoms in cystic fibrosis patients.
Besides its role in calcium-activated phospholipid scrambling, ANO6 protein is involved in several other physiological processes. It has been shown to play a role in exosome release, the secretion of small extracellular vesicles involved in intercellular communication. ANO6 has also been implicated in mediating calcium-activated chloride currents and volume-regulated anion channels in certain cell types.
Customer Reviews (4)
Write a reviewThis information is crucial for researchers in understanding the protein's behavior and interaction within their specific experimental context.
The manufacturer offers exceptional technical assistance, guiding researchers through various stages of their experiments.
By providing comprehensive data and resources, the manufacturer enables researchers to design and implement their trials with confidence, ensuring the desired outcomes.
Its reliable bioactivity makes it an ideal choice for a diverse range of experimental applications.
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