apcs
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  • Official Full Name
  • amyloid P component, serum
  • Background
  • The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.
  • Synonyms
  • APCS; amyloid P component, serum; SAP; PTX2; MGC88159; serum amyloid P-component; pentaxin-related; OTTHUMP00000024355; 9.5S alpha-1-glycoprotein
Cat.#:APCS-728MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse APCS Protein, His-tagged
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Cat.#:APCS-2311HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human APCS Protein, MYC/DDK-tagged
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Cat.#:APCS-674HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human APCS protein, GST-tagged
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Cat.#:APCS-8600HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human APCS, His tagged
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Cat.#:APCS-9734HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APCS, GST-tagged
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Cat.#:Apcs-585MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Apcs, His tagged
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Cat.#:Apcs-6863RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Apcs, His tagged
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Cat.#:Apcs-7095RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Apcs protein, His-tagged
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Cat.#:APCS-72HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Amyloid P Component, Serum, T7-tagged
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Cat.#:APCS-31189THTag:N/A
Source (Host):Species:Human
Product nameNative Human APCS
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Cat.#:APCS-8258HTag:N/A
Source (Host):Human SerumSpecies:Human
Product nameNative Human Serum Amyloid P
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Cat.#:APCS-1269HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human APCS cell lysate
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Cat.#:APCS-3089MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse APCS cell lysate
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Cat.#:APCS-1761RCLTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat APCS cell lysate
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Cat.#:Apcs-57MTag:N/A
Source (Host):Species:Mouse
Product nameMouse SAP Reference Standard
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Cat.#:Apcs-90RTag:N/A
Source (Host):Species:Rat
Product nameRat SAP Reference Standard
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Cat.#:Apcs-4893MTag:N/A
Source (Host):Mouse SerumSpecies:Mouse
Product nameMouse Apcs Reference serum
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Involved Pathway

APCS involved in several pathways and played different roles in them. We selected most pathways APCS participated on our site, such as Amyloid formation, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with APCS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amyloid formation
HIST2H3C; SEMG1; ODAM; CEACAM21; NAT8; CST3; TTR; SAA1; TGFBI; LTF
Metabolism of proteins
SPCS3; DPH1; LTF; MPDU1A; ST6GALNAC1.2; IGFBP6B; GZMH; LDHD; LMAN2L; EID3

Protein Function

APCS has several biochemical functions, for example, calcium ion binding, carbohydrate binding, complement component C1q binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APCS itself. We selected most functions APCS had, and list some proteins which have the same functions with APCS. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein CRP; LDLRA; OTOFA; ANXA11B; TESC; PCDHGB2; TMPRSS6; TESCB; ACTN4; CABYR
Function carbohydrate binding
Related Protein KLRK1; CLEC1A; ASGR1; GALNT18A; LY75; FCER2; CLEC4E; PYGB; Fcer2a; EMC7
Function complement component C1q binding
Related Protein C1QBP; PTX3; CALR; APCS; C4A; CRP; CD93
Function unfolded protein binding
Related Protein CALRL2; DNAJA3A; SIL1; TOR1A; DNAJA1; NAP1L4; SRSF12; CALR3; CCT7; TAPBP
Function virion binding
Related Protein PVRL1; PTX3; CLEC4M; CD209; PPIA; TSG101; APCS; HSP90B1; HIPK2

Interacting Protein

APCS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APCS here. Most of them are supplied by our site. Hope this information will be useful for your research of APCS.
GOT2; GK; GRB2; HES1; COPS5; d-mannose

APCS Related Articles

Veninga, H; Borg, EGF; et al. Antigen targeting reveals splenic CD169(+) macrophages as promoters of germinal center B-cell responses. EUROPEAN JOURNAL OF IMMUNOLOGY 45:747-757(2015).
Zhang, Y; Hu, XY; et al. Anti-CD40-induced inflammatory E-cadherin plus dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 34:-(2015).