apoa5
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  • Official Full Name
  • apolipoprotein A-V
  • Background
  • Apolipoproteins are proteins that bind lipids (oil-soluble substances such as fat and cholesterol) to form lipoproteins. They transport the lipids through the lymphatic and circulatory systems. The lipid components of lipoproteins are insoluble in water. However, because of their detergent-like (amphipathic) properties, apolipoproteins and other amphipathic molecules (such as phospholipids) can surround the lipids, creating the lipoprotein particle that is itself water-soluble, and can thus be carried through water-based circulation (i.e., blood, lymph). Apolipoproteins also serve as enzyme cofactors, receptor ligands, and lipid transfer carriers that regulate the metabolism of lipoproteins and their uptake in tissues.
  • Synonyms
  • UNQ411/PRO773; APOAV; RAP3; apo-AV; apolipoprotein A5; regeneration-associated protein 3
Cat.#:APOA5-103HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human APOA5, Flag-tagged
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Cat.#:APOA5-2476HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human APOA5, His-tagged
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Cat.#:APOA5-693HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human APOA5 protein, GST-tagged
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Cat.#:APOA5-787HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human APOA5
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Cat.#:APOA5-9750HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APOA5, His-tagged
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Cat.#:APOA5-1783MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse APOA5 Protein
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Cat.#:Apoa5-2088MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Apoa5 protein, His & GST-tagged
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Cat.#:Apoa5-2089RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Apoa5 protein, His-tagged
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Cat.#:APOA5-720RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat APOA5 Protein
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Cat.#:APOA5-8787HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human APOA5 293 Cell Lysate
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Involved Pathway

APOA5 involved in several pathways and played different roles in them. We selected most pathways APOA5 participated on our site, such as Chylomicron-mediated lipid transport, Fatty acid, triacylglycerol, and ketone body metabolism, Lipid digestion, mobilization, and transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chylomicron-mediated lipid transport
APOA5; APOA1B; MTP; APOA4B.1; APOEA; APOBB.1; APOA4A; APOA4B.2; APOEB; APOC2
Fatty acid, triacylglycerol, and ketone body metabolism
ANKRD1; ACOT10; GRHL1; MED26; ACOT2; DECR1; AGPAT6; DGAT1B; ACOT11; ACOT9.2
Lipid digestion, mobilization, and transport
CLPS; Alb; CETP; APOEB; MTP; LMF1; APOA4A; APOA5; FABP12; APOC2
Lipoprotein metabolism
APOA4B.2; ABCA1; APOA5; APOEA; APOC2; APOF; MTP; APOA4A; Alb; APOBB.1
Metabolism
CETP; ADK; PPM1LB; OAZ3; FAAH2; SLC5A4; GPHNA; CYP2A7; UROC1; DPYD
Metabolism of lipids and lipoproteins
CYP2AD6; LMF1; GRHL1; ACER1; PHOSPHO1; PLIN2; COQ7; MED19; MED16; ACOT13
PPAR signaling pathway
RXRG; ACSBG2; GK; FABP5; LPL; ME1; FABP2; SCDB; ACADL; RXRAA
PPARA activates gene expression
MED29; CTGF; MED21; GRHL1; MED8; PLIN2; MED25; MED10; MED15; MED7

Protein Function

APOA5 has several biochemical functions, for example, cholesterol binding, cholesterol transporter activity, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APOA5 itself. We selected most functions APOA5 had, and list some proteins which have the same functions with APOA5. You can find most of the proteins on our site.
Function
Related Protein
Function cholesterol binding
Related Protein TSPO2; STARD3; PROM2; APOEA; APOA4B.2; NR1H3; OSBPL1A; STARD6; APOC3; SCP2
Function cholesterol transporter activity
Related Protein ABCG1; APOA5; APOEB; APOA4; ABCA4; APOA1A; ABCA4A; ABCA7; CETP; APOA1
Function enzyme activator activity
Related Protein TRIM23; PPP1R12B; DCP1A; ASAP2; GMFG; LTC4S; CTSA; PRKCD; GLC8; CASP9
Function enzyme binding
Related Protein GSTM2; TSPAN5; MAPK14; A2M; CDC20; ATP6AP2; PCBP2; TMBIM6; HAND2; CSF3
Function heparin binding
Related Protein ADAMTS1; Epy; CCL5; HDGF; FN1; GREM2; KAL1; FGF10; CCL2; CCL23
Function lipase activator activity
Related Protein APOA5
Function lipase binding
Related Protein PLIN5; FAF2; APOB; APOA5; GPIHBP1; LRPAP1
Function lipid binding
Related Protein FABP7A; FABP7; RUFY1; UNC119B; PTEN; APOL4; PFN4; STARD8; CYP21A1; ACBD5A
Function lipoprotein lipase activator activity
Related Protein APOA5; APOC2; APOH
Function lipoprotein particle receptor binding
Related Protein LRP1; APOA5; Reln
Function low-density lipoprotein particle receptor binding
Related Protein SLC9A3R2; CRP; APOB; AP2M1; LDLRAP1; LRP2; HSP90B1; APOA5; PCSK9; APOEA
Function phosphatidylcholine binding
Related Protein APOA4; SERPINA5; APOA4A; ESYT2; GPR119; CHMP2A; GPR12; CETP; CHMP3; APOA1
Function phosphatidylcholine-sterol O-acyltransferase activator activity
Related Protein APOC1; APOA1; APOA5; APOEB; APOA4A; APOE; APOA1A; APOA2; APOEA; APOA4
Function phospholipid binding
Related Protein LRBA; ARHGAP44; PRKCI; APOM; APOE; HIP1RB; BAD; PAFAH2; SDPR; PON1

Interacting Protein

APOA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOA5.
LPL; LPL; FAS; RAB5B; SMARCD1; q99ib8-pro_0000045598

APOA5 Related Articles

Ashraf, AP; Beukelman, T; et al. Type 1 Hyperlipoproteinemia and Recurrent Acute Pancreatitis due to Lipoprotein Lipase Antibody in a Young Girl with Sjogren's Syndrome. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 96:3302-3307(2011).
Chen, Q; Reis, SE; et al. Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study. JOURNAL OF LIPID RESEARCH 52:801-807(2011).