apoa5
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  • Official Full Name
  • apolipoprotein A-V
  • Background
  • Apolipoproteins are proteins that bind lipids (oil-soluble substances such as fat and cholesterol) to form lipoproteins. They transport the lipids through the lymphatic and circulatory systems. The lipid components of lipoproteins are insoluble in water. However, because of their detergent-like (amphipathic) properties, apolipoproteins and other amphipathic molecules (such as phospholipids) can surround the lipids, creating the lipoprotein particle that is itself water-soluble, and can thus be carried through water-based circulation (i.e., blood, lymph). Apolipoproteins also serve as enzyme cofactors, receptor ligands, and lipid transfer carriers that regulate the metabolism of lipoproteins and their uptake in tissues.
  • Synonyms
  • UNQ411/PRO773; APOAV; RAP3; apo-AV; apolipoprotein A5; regeneration-associated protein 3
Cat.#:APOA5-103HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human APOA5, Flag-tagged
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Cat.#:APOA5-2476HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human APOA5, His-tagged
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Cat.#:APOA5-693HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human APOA5 protein, GST-tagged
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Cat.#:APOA5-787HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human APOA5
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Cat.#:APOA5-9750HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APOA5, His-tagged
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Cat.#:APOA5-1783MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse APOA5 Protein
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Cat.#:Apoa5-2088MTag:His|GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Apoa5 protein, His & GST-tagged
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Cat.#:Apoa5-2089RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Apoa5 protein, His-tagged
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Cat.#:APOA5-720RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat APOA5 Protein
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Cat.#:APOA5-8787HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human APOA5 293 Cell Lysate
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Involved Pathway

APOA5 involved in several pathways and played different roles in them. We selected most pathways APOA5 participated on our site, such as Chylomicron-mediated lipid transport, Fatty acid, triacylglycerol, and ketone body metabolism, Lipid digestion, mobilization, and transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chylomicron-mediated lipid transport
APOA4B.2; APOEA; MTP; APOA4B.1; APOA4A; APOEB; APOC2; APOBB.1; APOA5; APOA1B
Fatty acid, triacylglycerol, and ketone body metabolism
ACOT9.2; MED6; ACOT2; CDK8; G0S2; CYP4A11; ANKRD1; ACOT11A; GPAT2; CDK19
Lipid digestion, mobilization, and transport
MTP; FABP1B.1; APOA4B.1; ABCA1; APOA4B.2; LPA; FABP9; LMF1; APOA4A; FABP11A
Lipoprotein metabolism
APOBB.1; LPA; ABCA1; MTP; APOA1B; APOA4B.2; APOA5; CETP; APOF; Alb
Metabolism
KCNG4; THEM5; ADHFE1; PDZD11; ELA2L; MED23; MED6; COX6A1; CIAPIN1; ECI1
Metabolism of lipids and lipoproteins
CYP2V1; DHCR7; CSNK1G2; CPT2; BCHE; ACOT11A; CYP4F11; CYP27B1; FABP11A; MED18
PPAR signaling pathway
ADIPOQB; ME1; SLC27A4; FABP7A; ACSL1; MMP1A; ACOX3; OLR1; UBC; FABP1
PPARA activates gene expression
TIAM2; MED22; APOA5; ANKRD1; SREBF2; MED18; MED21; MED29; MED25; MED20

Protein Function

APOA5 has several biochemical functions, for example, cholesterol binding, cholesterol transporter activity, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APOA5 itself. We selected most functions APOA5 had, and list some proteins which have the same functions with APOA5. You can find most of the proteins on our site.
Function
Related Protein
Function cholesterol binding
Related Protein APOE; STAR; OSBP2; ERLIN2; APOA2; SOAT1; ERLIN1; CAV1; OSBPL7; APOA4
Function cholesterol transporter activity
Related Protein ABCA13; APOA1A; ABCA7; APOA5; APOA4A; APOB; CETP; APOEB; ABCG1; ABCA4
Function enzyme activator activity
Related Protein MMP15; ALDH1A2; OGT; GMFG; CLPSL1; SEC14L2; MMP17; PRKCE; SFTPBB; RICTOR
Function enzyme binding
Related Protein DAXX; DAOA; UBE2I; RCOR3; ATP2A2; RYR2; LGALS9; HSPA5; RPS19BP1; HIST1H2AL
Function heparin binding
Related Protein SAA1; PRELP; FGF1; SFRP1; LTBP2; FGF12; COL13A1; GM4980; NELL2; VEGFB
Function lipase activator activity
Related Protein APOA5
Function lipase binding
Related Protein APOA5; GPIHBP1; PLIN5; LRPAP1; FAF2; APOB
Function lipid binding
Related Protein CYTH4; RBP2A; LPAR2; BPIFB3; OSBPL9; PAQR7B; ALOX8; STARD6; PACSIN1B; MELK
Function lipoprotein lipase activator activity
Related Protein APOH; APOC2; APOA5
Function lipoprotein particle receptor binding
Related Protein APOA5; Reln; LRP1
Function low-density lipoprotein particle receptor binding
Related Protein APOEA; LDLRAP1; ARRB2; AP2M1; LRP2; PCSK9; APOA5; SNX17; APOB; HSP90B1
Function phosphatidylcholine binding
Related Protein ALDOB; PCTP; APOA4B.1; CHMP2A; APOA1A; APOA2; GPR12; APOA4A; VPS24; RASGRP1
Function phosphatidylcholine-sterol O-acyltransferase activator activity
Related Protein APOA5; APOA1A; APOE; APOEB; APOEA; APOA4B.1; APOA1; APOA2; APOA4B.2; APOA4A
Function phospholipid binding
Related Protein ESYT1; PICALMA; OSBPL1A; MYOF; F3; TICAM2; HIP1RB; APOM; BAIAP2L2; PTAFR

Interacting Protein

APOA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOA5.
LPL; LPL; FAS; RAB5B; SMARCD1; q99ib8-pro_0000045598

APOA5 Related Articles

Ashraf, AP; Beukelman, T; et al. Type 1 Hyperlipoproteinemia and Recurrent Acute Pancreatitis due to Lipoprotein Lipase Antibody in a Young Girl with Sjogren's Syndrome. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 96:3302-3307(2011).
Chen, Q; Reis, SE; et al. Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study. JOURNAL OF LIPID RESEARCH 52:801-807(2011).