Arf2
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Official Full Name
ADP-ribosylation factor 2
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Synonyms
Arf2; ADP-ribosylation factor 2;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Rat | ARF2-748R | Recombinant Rat ARF2 Protein | Mammalian Cell | His | ||
Rat | Arf2-3206R | Recombinant Rat Arf2, His-tagged | E.Coli or Yeast | His | 181 | |
Rat | ARF2-404R-B | Recombinant Rat ARF2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ARF2-404R | Recombinant Rat ARF2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Zebrafish | ARF2-11548Z | Recombinant Zebrafish ARF2 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- Arf2 Related Signal Pathway
Arf2 involved in several pathways and played different roles in them. We selected most pathways Arf2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Arf2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Arf2 has several biochemical functions, for example, GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Arf2 itself. We selected most functions Arf2 had, and list some proteins which have the same functions with Arf2. You can find most of the proteins on our site.
Function | Related Protein |
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GTP binding | SRP54;RAB41;DNM2B;RAB40AL;RRAGCA;RAP1A;DNAJC27;RAB3DB;SEPT10 |
Arf2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Arf2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Arf2.
- Q&As
- Reviews
Q&As (30)
Ask a questionYes, Arf2 can interact with other members of the Arf family, forming heterodimers or participating in protein complexes involved in different cellular processes.
Yes, Arf2 has been shown to regulate apoptosis, or programmed cell death, by influencing the activity of pro-apoptotic and anti-apoptotic proteins.
Yes, Arf2 has been shown to regulate cell cycle progression by interacting with proteins involved in cell cycle control, such as cyclin-dependent kinases (Cdks) and cyclins.
While Arf2 is primarily known for its intracellular functions, recent studies suggest that it may also play a role in intercellular signaling, particularly in the context of the tumor microenvironment and immune responses.
Studies have shown that Arf2 is not essential for cell survival under normal conditions. However, its dysregulation can lead to disruption of cellular processes and contribute to disease progression.
Arf2 activity is regulated by multiple mechanisms, including GEFs that activate it, GAPs that deactivate it, and other regulatory proteins that modulate its function and localization.
Yes, Arf2 is involved in cellular senescence, a state of irreversible cell cycle arrest that contributes to aging and tumor suppression. Arf2 can activate pathways leading to cellular senescence in response to various stresses.
Arf2 is being investigated as a potential therapeutic target for neurodegenerative diseases due to its involvement in pathways implicated in these diseases, such as protein aggregation and cellular stress responses.
Therapeutic strategies targeting Arf2 include small molecule inhibitors or activators, RNA interference techniques, and gene therapies aimed at modulating its expression or activity to restore cellular equilibrium or counter disease progression.
Arf2 interacts with various effectors and regulators to carry out its functions. Some examples include COPI and clathrin adaptor proteins, phospholipase D (PLD), and ARF-GAPs (GTPase-activating proteins).
Mutations in the Arf2 gene can result in functional alterations, affecting its ability to interact with other proteins or perform its normal cellular functions. These mutations can have implications for cellular processes and disease development.
Yes, Arf2 has emerged as a potential target for drug development due to its involvement in various diseases. Modulators of Arf2 activity and protein-protein interactions are being explored as potential therapeutic agents.
There is limited evidence suggesting that Arf2 may play a role in tumor metastasis, although more research is needed to fully understand its involvement and mechanisms.
Yes, ongoing research focuses on uncovering the precise molecular mechanisms of Arf2-mediated cellular processes and its potential as a therapeutic target for various diseases.
Yes, Arf2 can interact with various proteins, including but not limited to, p53, MDM2, E2F transcription factors, p300/CBP coactivators, p19ARF, and ribosomal proteins.
Arf2 can contribute to cancer development through various mechanisms, including its ability to inhibit cell proliferation and induce cell cycle arrest, its involvement in tumor suppressor pathways, and its interactions with oncogenic proteins.
Yes, dysregulation of Arf2 has been implicated in diseases such as cancer, Alzheimer's disease, Parkinson's disease, and metabolic disorders.
Yes, Arf2 can be regulated post-translationally through modifications such as phosphorylation, acetylation, and ubiquitination, which can influence its stability, localization, and activity.
Yes, Arf2 has been reported to participate in DNA repair processes by interacting with proteins involved in DNA damage response pathways.
Yes, Arf2 is involved in maintaining genomic stability by regulating DNA replication, repair, and checkpoint control mechanisms.
Yes, several compounds have been developed to selectively inhibit or activate Arf2 activity. For example, brefeldin A is a well-known inhibitor, while secinH3 is an Arf-GEF-specific activator for Arf2.
Yes, Arf2 has been implicated in neuronal development and function, including neurite outgrowth, synapse formation, and neurotransmitter release.
Yes, Arf2 has been shown to be involved in embryonic development, particularly in regulating cell cycle exit and differentiation of specific cell lineages.
Dysregulation of Arf2 has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes, highlighting its significance in cellular homeostasis.
Arf2 is being explored as a potential target for cancer therapy, as modulating its activity or expression could have therapeutic effects in certain cancer types.
Yes, Arf2 can regulate cellular metabolism by interacting with proteins involved in metabolic pathways, such as AMP-activated protein kinase (AMPK), and modulating energy homeostasis.
There is evidence suggesting that Arf2 expression levels can serve as a prognostic marker for certain types of cancer, including breast cancer and lung cancer.
Arf2 is known to be involved in cellular stress responses, such as DNA damage response, oxidative stress, and endoplasmic reticulum stress, by regulating pathways that help cells cope with and survive these stresses.
Yes, Arf2 has been shown to participate in immune responses, particularly in the context of antigen presentation, T cell activation, and cytokine signaling.
Yes, Arf2 can interact with chromatin remodeling complexes, such as SWI/SNF and INO80, which are involved in modulating chromatin structure and gene expression.
Customer Reviews (8)
Write a reviewThis flexibility allows researchers to select the most suitable form for their particular experimental setup, enhancing the efficiency and accuracy of their trials.
The Arf2 protein exhibits remarkable performance in Western blotting (WB) experiments.
The versatility and efficacy of Arf2 in these applications make it an invaluable tool for researchers.
Researchers can rely on Arf2 to deliver reliable and accurate results in ELISA experiments, ensuring precise measurement and quantification of target proteins.
researchers using the Arf2 protein can benefit from its high purity and quality, ensuring reliable results.
With its well-characterized nature and availability in various formats, the Arf2 protein is an advantageous tool that aids researchers in achieving their scientific goals.
the Arf2 protein is available in different formats, including recombinant and purified variants.
The protein's reliability and reproducibility in WB ensure accurate analysis of target proteins, while its suitability for electron microscopy structure analysis enables detailed examination of molecular structures.
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