ARHGAP26 Protein, Rho GTPase activating protein 26


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Official Full Name Rho GTPase activating protein 26
Background Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene.
Synonyms ARHGAP26; Rho GTPase activating protein 26; rho GTPase-activating protein 26; GRAF; GTPase regulator associated with the focal adhesion kinase pp125; KIAA0621; OPHN1L; OPHN1L1; oligophrenin-1-like protein; GTPase regulator associated with focal adhesion k
    • Species :
    • Chicken
    • Human
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ARHGAP26-111HCL Recombinant Human ARHGAP26 cell lysate N/A
    Human ARHGAP26-2514H Recombinant Human ARHGAP26 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ARHGAP26-767H Recombinant Human ARHGAP26 protein, GST-tagged Wheat Germ GST
    Human ARHGAP26-9822H Recombinant Human ARHGAP2, His-tagged E.coli His
    Chicken ARHGAP26-6748C Recombinant Chicken ARHGAP26 Mammalian Cell His

    ARHGAP26 involved in several pathways and played different roles in them. We selected most pathways ARHGAP26 participated on our site, such as Rho GTPase cycle, Signal Transduction, Signaling by Rho GTPases, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP26 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signal Transduction ABCA4A; WDR35; DHRS4; AES; USP15; RLBP1B; DCLRE1B; SOUL3; SOX4B; PRKCHB
    Signaling events mediated by focal adhesion kinase KLF8; ARHGEF28; ARHGAP26; BMX; ACTA1

    ARHGAP26 has several biochemical functions, for example, GTPase activator activity, phospholipid binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP26 itself. We selected most functions ARHGAP26 had, and list some proteins which have the same functions with ARHGAP26. You can find most of the proteins on our site.

    Function Related Protein
    GTPase activator activity TBC1D8; CHML; GMIP; RALBP1; DEPDC1B; ARAP1; ARHGAP29B; SRGAP1; ACAP3B; SRGAP3
    phospholipid binding NBEA; NSFL1C; BPIFC; AGAP1; TEC; APOA2; SDPR; NUP35; PSD2; NR5A2
    protein binding ATXN2; GKAP1; EFHC2; GGA3; GPATCH8; KRTAP13-3; TRIM22; PPP3R2; CYP4F2; TWIST1

    ARHGAP26 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP26 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP26.

    PKN3; CDC42EP2; apc; SRPK1; Nyap1; Nyap2; MYO16

    Jarius, S; Scharf, M; et al. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. Journal of Neuroinflammation 11:-(2014).
    Hasler, SLA; Vallis, Y; et al. GRAF1a is a brain-specific protein that promotes lipid droplet clustering and growth, and is enriched at lipid droplet junctions. JOURNAL OF CELL SCIENCE 127:4602-4619(2014).

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