| Description : |
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
92.1 kDa |
| AA Sequence : |
MGLPALEFSDCCLDSPHFRETLKSH EAELDKTNKFIKELIKDGKSLISAL KNLSSAKRKFADSLNEFKFQCIGDA ETDDEMCIARSLQEFATVLRNLEDE RIRMIENASEVLITPLEKFRKEQIG AAKEAKKKYDKETEKYCGILEKHLN LSSKKKESQLQEADSQVDLVRQHFY EVSLEYVFKVQEVQERKMFEFVEPL LAFLQGLFTFYHHGYELAKDFGDFK TQLTISIQNTRNRFEGTRSEVESLM KKMKENPLEHKTISPYTMEGYLYVQ EKRHFGTSWVKHYCTYQRDSKQITM VPFDQKSGGKGGEDESVILKSCTRR KTDSIEKRFCFDVEAVDRPGVITMQ ALSEEDRRLWMEAMDGREPVYNSNK DSQSEGTAQLDSIGFSIIRKCIHAV ETRGINEQGLYRIVGVNSRVQKLLS VLMDPKTASETETDICAEWEIKTIT SALKTYLRMLPGPLMMYQFQRSFIK AAKLENQESRVSEIHSLVHRLPEKN RQMLQLLMNHLANVANNHKQNLMTV ANLGVVFGPTLLRPQEETVAAIMDI KFQNIVIEILIENHEKIFNTVPDMP LTNAQLHLSRKKSSDSKPPSCSERP LTLFHTVQSTEKQEQRNSIINSSLE SVSSNPNSILNSSSSLQPNMNSSDP DLAVVKPTRPNSLPPNPSPTSPLSP SWPMFSAPSSPMPTSSTSSDSSPVR SVAGFVWFSVAAVVLSLARSSLHAV FSLLVNFVPCHPNLHLLFDRPEEAV HEDSSTPFRKAKALYACKAEHDSEL SFTAGTVFDNVHPSQEPGWLEGTLN GKTGLIPENYVEFLTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
