Rho (see ARHA; MIM 165390)-like small GTPases are involved in many cellular processes, and they are inactive in the;GDP-bound state and active in the GTP-bound state. GTPase-activating proteins, such as ARHGAP27, inhibit Rho-like;proteins by stimulating their intrinsic GTPase activity (Katoh and Katoh, 2004 (PubMed 15492870)).
ARHGAP27; Rho GTPase activating protein 27; SH3 domain containing 20 , SH3D20; rho GTPase-activating protein 27; CAMGAP1; FLJ43547; SH3P20; SH3 domain containing 20; SH3 domain-containing protein 20; rho-type GTPase-activating protein 27; CIN85-associated
ARHGAP27 has several biochemical functions, for example, GTPase activator activity, SH3 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP27 itself. We selected most functions ARHGAP27 had, and list some proteins which have the same functions with ARHGAP27. You can find most of the proteins on our site.
Function GTPase activator activity
Related Protein SRGAP2A; TBC1D5; ARHGDIA; RGS2; SRGAP2; ARHGDIB; ARAP3; TSC2; MYO9B; ELMOD2
Function SH3 domain binding
Related Protein SIRPA; ADAM17; MAPK15; WIPF3; PLSCR1; ELMO3; CNTNAP1; ARHGAP6; PLSCR3; DNM2
ARHGAP27 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP27 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP27.
ARHGAP27 Related Articles
Connelly, TM; Berg, AS; et al. T-cell activation Rho GTPase-activating protein expression varies with inflammation location and severity in Crohn's disease. JOURNAL OF SURGICAL RESEARCH 190:457-464(2014).
Au, SLK; Wong, CCL; et al. EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers. PLOS ONE 8:-(2013).