arhgef12
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  • Official Full Name
  • Rho guanine nucleotide exchange factor (GEF) 12
  • Background
  • Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • ARHGEF12; Rho guanine nucleotide exchange factor (GEF) 12; rho guanine nucleotide exchange factor 12; KIAA0382; LARG; leukemia-associated rho guanine nucleotide exchange factor; Leukemia-associated RhoGEF; PRO2792; Rho guanine exchange factor (GEF) 12; Similar to Mouse Lsc oncogene
Cat.#:ARHGEF12-781HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ARHGEF12 protein, GST-tagged
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Cat.#:ARHGEF12-8734HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ARHGEF12 293 Cell Lysate
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Involved Pathway

ARHGEF12 involved in several pathways and played different roles in them. We selected most pathways ARHGEF12 participated on our site, such as Vascular smooth muscle contraction, Axon guidance, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF12 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Vascular smooth muscle contraction
GNA11; KCNMB4; PRKACA; PLA2G12A; CALM4; GNAS; GNA12; GNA13A; MYL9A; AGTR1B
Axon guidance
CSNK2B; COL9A1; SLC14A2; ROCK2; SEMA6C; RANBP9; DPYSL4; RGS3; SEMA3D; HBEGF
Platelet activation
ITGA2; MYL12A; RAP1A; FGA; MYL12B; P2RY12; FCGR2A; LYN; PIK3R2; ITGB1
Regulation of actin cytoskeleton
ARAF; PIP5K1A; PIP5K1AB; EZRB; IQGAP3; ITGB6; ACTN3; PXNA; PXN; FGF9
Tuberculosis
IFNGR2; ITGB2L; FCGR3; HLA-DRA; ATP6V0D2; HLA-DQA1; FCGR1; Pla2r1; CD209A; CD209
Pathways in cancer
BMP2; RXRB; RBX1; PDGFA; MAPK9; RALBP1; PRKCG; BAD; WNT8A; GLI1
Proteoglycans in cancer
TGFB2; HCLS1; FZD9; PAK1; PLAU; HRAS; NANOG; MAPK12; CBLC; SRC

Protein Function

ARHGEF12 has several biochemical functions, for example, G-protein coupled receptor binding, GTPase activator activity, Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF12 itself. We selected most functions ARHGEF12 had, and list some proteins which have the same functions with ARHGEF12. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein coupled receptor binding
Related Protein GNA13B; GNA12A; INSL3; S1PR1; GNAL; PROK2; RSPO2; NPB; PROK1; GNAT2
Function GTPase activator activity
Related Protein TBC1D3B; ARHGAP19; ARHGAP20; SIPA1L2; GDI2; ELMOD1; LLGL1; LLGL2; SRGAP2B; RGS2
Function Rho guanyl-nucleotide exchange factor activity
Related Protein SOS1; ARHGEF2; AKAP13; ARHGEF11; KALRN; TIAM2; ARHGEF7; FGD4A; DOCK11; PLEKHG2
Function protein binding
Related Protein MAGEH1; ELMOD3; MOBKL1A; BRAP; DBNDD2; IGSF1; SIGLEC6; DYRK1B; MATN3; OPRD1

Interacting Protein

ARHGEF12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF12.
IGF1R; RHOA; Lpar1; ORF; ABCA1; q7db74_eco57; Lpar2; o68742_yerpe; hmsH; ARRB2

ARHGEF12 Related Articles

Majumdar, M; Seasholtz, TM; et al. A Rho exchange factor mediates thrombin and G alpha(12)-induced cytoskeletal responses. JOURNAL OF BIOLOGICAL CHEMISTRY 274:26815-26821(1999).