ARHGEF12 Protein, Rho guanine nucleotide exchange factor (GEF) 12


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Official Full Name Rho guanine nucleotide exchange factor (GEF) 12
Background Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms ARHGEF12; Rho guanine nucleotide exchange factor (GEF) 12; rho guanine nucleotide exchange factor 12; KIAA0382; LARG; leukemia-associated rho guanine nucleotide exchange factor; Leukemia-associated RhoGEF; PRO2792; Rho guanine exchange factor (GEF) 12; Similar to Mouse Lsc oncogene
    • Species :
    • Human
    • Source :
    • HEK293
    • Wheat Germ
    • Tag :
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ARHGEF12-781H Recombinant Human ARHGEF12 protein, GST-tagged Wheat Germ GST
    Human ARHGEF12-8734HCL Recombinant Human ARHGEF12 293 Cell Lysate HEK293 N/A

    ARHGEF12 involved in several pathways and played different roles in them. We selected most pathways ARHGEF12 participated on our site, such as Vascular smooth muscle contraction, Axon guidance, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Vascular smooth muscle contraction GUCY1A3; PPP1CA; PLA2G2A; ITPR3; MAP2K2B; CALM4; MAP2K2; MYLK; ITPR1; PLA2G4A
    Platelet activation PLCB4; PLCB3; F2R; ITPR3; LCP2; P2RY1; ITGA2; MAPK3; PLCB1; VWF
    Regulation of actin cytoskeleton F2; VAV2; ITGB2; ITGA11A; PFN3; PPP1R12A; ABI2B; RAC1; MYH9; CDC42
    Tuberculosis IFNA17; HLA-DOA; LAMP2; Ifna15; IRAK1; IRAK2; AKT2; RFXAP; IRAK4; HLA-DRB4
    Pathways in cancer PRKCA; WNT5B; FZD6; ITGAV; PLD1; WNT3; PIAS2; FGF7; PLCG1; GNG3
    Proteoglycans in cancer FLNA; GAB1; WNT8A; THBS1; FN1; WNT7B; TLR2; CBL; MMP2; FZD3

    ARHGEF12 has several biochemical functions, for example, G-protein coupled receptor binding, GTPase activator activity, Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF12 itself. We selected most functions ARHGEF12 had, and list some proteins which have the same functions with ARHGEF12. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled receptor binding SFTPB; GNA14; RLN3; DNAJA1; HSPA1B; GNA15.4; USP20; FCN1; RSPO4; ARRB2
    GTPase activator activity TBC1D15; RASAL2; GIT2; DLC1; SH3BGRL3; ASAP3; LLGL1; RGS17; PGAM5; ARHGAP42
    Rho guanyl-nucleotide exchange factor activity DOCK9; ARHGEF9; ARHGEF7B; ARHGEF1; ARHGEF25; DOCK10; FGD6; ARHGEF3; AKAP13; FGD1
    protein binding GEMIN8; PAFAH1B3; TTI1; CREB1; CCDC112; NFATC1; SMYD1; CCHCR1; TAF7L; GET4

    ARHGEF12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF12.

    IGF1R; RHOA; Lpar1; ORF; ABCA1; q7db74_eco57; Lpar2; o68742_yerpe; hmsH; ARRB2

    Majumdar, M; Seasholtz, TM; et al. A Rho exchange factor mediates thrombin and G alpha(12)-induced cytoskeletal responses. JOURNAL OF BIOLOGICAL CHEMISTRY 274:26815-26821(1999).

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