ARHGEF17
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Official Full Name
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 17 -
Synonyms
ARHGEF17;Rac/Cdc42 guanine nucleotide exchange factor (GEF) 17
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARHGEF17-1892M | Recombinant Mouse ARHGEF17 Protein | Mammalian Cells | Mouse | His |
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| ARHGEF17-693M | Recombinant Mouse ARHGEF17 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| ARHGEF17-693M-B | Recombinant Mouse ARHGEF17 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ARHGEF17 involved in several pathways and played different roles in them. We selected most pathways ARHGEF17 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE,G alpha (12/13) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NRAGE signals death through JNK | ABR,ARHGEF18,PLEKHG2,ECT2,AKAP13,FGD4A,DCLRE1B,NET1,ARHGEF3,ARHGAP4 |
| Rho GTPase cycle | ARHGAP33,ARHGAP40,ARHGAP8,GDI2,ARHGAP17B,ARHGAP24,ARHGAP4A,RHOT1A,TAGAP1,OPHN1 |
| Signaling by Rho GTPases | DCLRE1B,TAGAP1,ARHGAP8,ARHGAP20,RHOT2,ARHGAP6,CIT,ARHGAP26,ROPN1,STARD13 |
| Signal Transduction | RBP4,RNF43,TAC2,DISP2,PRC1,LEO1,CCDC88C,OPN1LW2,CXCL11.8,ARHGEF1A |
| GPCR downstream signaling | LTB4R,NPB,RGS21,CCL19A.2,DRD2,PTHLHA,GPR68,KALRN,NPSR1,SSTR4 |
| Signaling by GPCR | OXGR1A.3,INSL5,TAS2R16,TRH,PYY,OPN5,CRHB,PLEKHG2,OPN4A,RGS12 |
| Cell death signalling via NRAGE, NRIF and NADE | FGD4A,TIAM2,AATF,ARHGEF18,PLEKHG2,TRIO,BCL2L11,ARHGEF9,FGD4,ARHGEF18A |
| G alpha (12/13) signalling events | ADRA1B,ITSN1,KALRN,OBSCN,ARHGAP4,ARHGEF1B,FGD2,RHOC,FGD4,ARHGEF3 |
Protein Function
ARHGEF17 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF17 itself. We selected most functions ARHGEF17 had, and list some proteins which have the same functions with ARHGEF17. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rho guanyl-nucleotide exchange factor activity | VAV3B,ABR,KALRNB,RASGRF2B,AKAP13,ARHGEF7,BCR,FGD3,PLEKHG6,PLEKHG7 |
| guanyl-nucleotide exchange factor activity | RALGPS2,RANGRF,TIAM2,SBF1,RAPGEF5B,DOCK6,ARHGEF37,DIS3,DOCK7,PLCE1 |
Interacting Protein
ARHGEF17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF17 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF17.
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References
- Zhao, X; Rotenberg, SA; et al. Phosphorylation of Cdc42 Effector Protein-4 (CEP4) by Protein Kinase C Promotes Motility of Human Breast Cells. JOURNAL OF BIOLOGICAL CHEMISTRY 289:25844-25854(2014).
- Fang, LT; Lee, S; et al. Comprehensive genomic analyses of a metastatic colon cancer to the lung by whole exome sequencing and gene expression analysis. INTERNATIONAL JOURNAL OF ONCOLOGY 44:211-221(2014).
