ARHGEF19
-
Official Full Name
Rho guanine nucleotide exchange factor (GEF) 19
-
Overview
Guanine nucleotide exchange factors (GEFs) such as ARHGEF19 accelerate the GTPase activity of Rho GTPases (see RHOA, MIM 165390). -
Synonyms
ARHGEF19; Rho guanine nucleotide exchange factor (GEF) 19; rho guanine nucleotide exchange factor 19; FLJ33962; WGEF; ARHGJ_HUMAN; ephexin-2; weakly similar to Rho GEF; RP4-733M16.1;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ARHGEF19-784H | Recombinant Human ARHGEF19 protein, GST-tagged | Wheat Germ | GST | ||
Human | ARHGEF19-1343HF | Recombinant Full Length Human ARHGEF19 Protein, GST-tagged | In Vitro Cell Free System | GST | 802 amino acids | |
Mouse | ARHGEF19-1894M | Recombinant Mouse ARHGEF19 Protein | Mammalian Cell | His | ||
Mouse | ARHGEF19-695M | Recombinant Mouse ARHGEF19 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ARHGEF19-695M-B | Recombinant Mouse ARHGEF19 Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
ARHGEF19 involved in several pathways and played different roles in them. We selected most pathways ARHGEF19 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|
ARHGEF19 has several biochemical functions, for example, GTPase activator activity, Rho guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF19 itself. We selected most functions ARHGEF19 had, and list some proteins which have the same functions with ARHGEF19. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
GTPase activator activity | GMIP;FAM13A;TBC1D20;ARHGAP31;NCKAP1L;GAPVD1;ARHGAP24;SOS1;RGS2 |
Rho guanyl-nucleotide exchange factor activity | PLEKHG2;ARHGEF11;KALRNB;ARHGEF28;ARHGEF12;ARHGEF3;FGD1;ALS2CL;ECT2 |
guanyl-nucleotide exchange factor activity | TBC1D10A;RINL;PTGIR;ARFGEF2;DOCK4B;FNIP1;NET1;RIC8;ARHGEF17 |
ARHGEF19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF19 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF19.
- Q&As
- Reviews
Q&As (13)
Ask a questionGenetic variations in the ARHGEF19 gene have been identified in some studies. These variations may contribute to individual differences in gene expression or protein function, but their specific implications are still under investigation.
Various experimental techniques can be employed to study ARHGEF19 protein. These may include molecular biology techniques like gene expression analysis, protein-protein interaction studies, and immunoblotting. Additionally, cellular assays, such as siRNA knockdown or overexpression studies, can be used to investigate the functional role of ARHGEF19 protein.
There is limited information available on the association of ARHGEF19 protein with diseases. Further research is needed to determine if any diseases or disorders are linked to this protein.
Currently, there is no evidence to suggest that ARHGEF19 protein can be used as a diagnostic marker for any specific diseases or conditions. However, ongoing research may reveal its potential significance as a diagnostic or prognostic marker in the future.
The subcellular localization of ARHGEF19 has not been extensively studied. However, some research suggests that it may localize primarily to the cytoplasm. Further research, such as cellular fractionation or immunofluorescence studies, would be needed to provide more detailed information on the subcellular localization of ARHGEF19 in different cell types and conditions.
The ARHGEF19 protein is generally conserved across different species, although the level of conservation may vary. Homologs of ARHGEF19 can be found in various organisms, including mammals, birds, reptiles, amphibians, and even certain invertebrates. The sequence similarity and conservation of key functional domains suggest that ARHGEF19 serves important roles across different species, although the specific functions and regulatory mechanisms may differ.
Currently, there are no established animal models specific to ARHGEF19 protein. However, researchers may use cell lines, such as neuronal cell lines, to study its cellular and molecular functions in vitro.
ARHGEF19 protein is known to be localized primarily in the cytoplasm based on existing data. Additional studies may provide more detailed information on its subcellular localization and potential translocation to different cellular compartments.
Currently, there are no well-established interacting partners of ARHGEF19 protein. More research is required to identify and understand its protein-protein interactions.
The presence of post-translational modifications (PTMs) on ARHGEF19 protein has not been extensively studied. However, it is plausible that the protein may undergo PTMs such as phosphorylation, acetylation, or ubiquitination, which can impact its stability, activity, or subcellular localization.
ARHGEF19 protein belongs to the Rho guanine nucleotide exchange factor (RhoGEF) family. It shares certain structural and functional similarities with other members of this family, including ARHGEF1, ARHGEF11, and ARHGEF25, which are implicated in various cellular processes.
Currently, there are no known therapeutic implications directly linked to ARHGEF19 protein. However, further research on its function and potential interactions may reveal therapeutic targets in the future.
Limited information is available regarding alternative splice variants of ARHGEF19 protein. Further investigations are required to determine if there are any alternative splicing isoforms and to understand their potential functional differences.
Customer Reviews (8)
Write a reviewAn ARHGEF19 protein manufacturer that also offers related reagents such as antibodies or assay kits can streamline the research process.
Its purity and consistency enable accurate and precise data analysis, ensuring the integrity of my research outcomes.
This support could range from assisting with experimental design to offering advice on optimal protein handling and storage conditions.
the ARHGEF19 protein's exceptional quality, reliability, and the manufacturer's unparalleled technical support make it a prime choice for researchers seeking to delve into the intricacies of angiogenesis, vascular development, and related fields.
It can be effectively employed in in vitro and in vivo studies, offering insights into the intricate mechanisms underlying angiogenesis, lipid metabolism, and cardiovascular diseases.
the manufacturer fosters scientific collaboration and knowledge sharing among researchers.
One of the primary advantages of the ARHGEF19 protein is its versatility in various trial applications.
This guarantees a continuous and uninterrupted availability of the protein for researchers, eliminating concerns about potential shortages or delays.
Ask a Question for All ARHGEF19 Products
Required fields are marked with *
My Review for All ARHGEF19 Products
Required fields are marked with *