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ARHGEF19

  • Official Full Name

    Rho guanine nucleotide exchange factor (GEF) 19

  • Overview

    Guanine nucleotide exchange factors (GEFs) such as ARHGEF19 accelerate the GTPase activity of Rho GTPases (see RHOA, MIM 165390).
  • Synonyms

    ARHGEF19; Rho guanine nucleotide exchange factor (GEF) 19; rho guanine nucleotide exchange factor 19; FLJ33962; WGEF; ARHGJ_HUMAN; ephexin-2; weakly similar to Rho GEF; RP4-733M16.1;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARHGEF19-784H Recombinant Human ARHGEF19 protein, GST-tagged Wheat Germ GST
Human ARHGEF19-1343HF Recombinant Full Length Human ARHGEF19 Protein, GST-tagged In Vitro Cell Free System GST 802 amino acids
Mouse ARHGEF19-1894M Recombinant Mouse ARHGEF19 Protein Mammalian Cell His
Mouse ARHGEF19-695M Recombinant Mouse ARHGEF19 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ARHGEF19-695M-B Recombinant Mouse ARHGEF19 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ARHGEF19 involved in several pathways and played different roles in them. We selected most pathways ARHGEF19 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ARHGEF19 has several biochemical functions, for example, GTPase activator activity, Rho guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF19 itself. We selected most functions ARHGEF19 had, and list some proteins which have the same functions with ARHGEF19. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activityGMIP;FAM13A;TBC1D20;ARHGAP31;NCKAP1L;GAPVD1;ARHGAP24;SOS1;RGS2
Rho guanyl-nucleotide exchange factor activityPLEKHG2;ARHGEF11;KALRNB;ARHGEF28;ARHGEF12;ARHGEF3;FGD1;ALS2CL;ECT2
guanyl-nucleotide exchange factor activityTBC1D10A;RINL;PTGIR;ARFGEF2;DOCK4B;FNIP1;NET1;RIC8;ARHGEF17

ARHGEF19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF19 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF19.

  • Q&As
  • Reviews

Q&As (13)

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Is there any genetic variation in the ARHGEF19 gene? 02/18/2023

Genetic variations in the ARHGEF19 gene have been identified in some studies. These variations may contribute to individual differences in gene expression or protein function, but their specific implications are still under investigation.

Are there any experimental techniques commonly used to study ARHGEF19 protein? 01/23/2023

Various experimental techniques can be employed to study ARHGEF19 protein. These may include molecular biology techniques like gene expression analysis, protein-protein interaction studies, and immunoblotting. Additionally, cellular assays, such as siRNA knockdown or overexpression studies, can be used to investigate the functional role of ARHGEF19 protein.

Is ARHGEF19 protein associated with any diseases? 06/25/2021

There is limited information available on the association of ARHGEF19 protein with diseases. Further research is needed to determine if any diseases or disorders are linked to this protein.

Can ARHGEF19 protein be used as a diagnostic marker? 04/04/2021

Currently, there is no evidence to suggest that ARHGEF19 protein can be used as a diagnostic marker for any specific diseases or conditions. However, ongoing research may reveal its potential significance as a diagnostic or prognostic marker in the future.

Is there any information available on the subcellular localization of ARHGEF19 protein? 03/26/2021

The subcellular localization of ARHGEF19 has not been extensively studied. However, some research suggests that it may localize primarily to the cytoplasm. Further research, such as cellular fractionation or immunofluorescence studies, would be needed to provide more detailed information on the subcellular localization of ARHGEF19 in different cell types and conditions.

Is ARHGEF19 protein conserved across different species? 01/15/2021

The ARHGEF19 protein is generally conserved across different species, although the level of conservation may vary. Homologs of ARHGEF19 can be found in various organisms, including mammals, birds, reptiles, amphibians, and even certain invertebrates. The sequence similarity and conservation of key functional domains suggest that ARHGEF19 serves important roles across different species, although the specific functions and regulatory mechanisms may differ.

Are there any animal models or cell lines used to study ARHGEF19 protein? 11/15/2020

Currently, there are no established animal models specific to ARHGEF19 protein. However, researchers may use cell lines, such as neuronal cell lines, to study its cellular and molecular functions in vitro.

Is there any information available on the subcellular localization of ARHGEF19 protein? 02/01/2020

ARHGEF19 protein is known to be localized primarily in the cytoplasm based on existing data. Additional studies may provide more detailed information on its subcellular localization and potential translocation to different cellular compartments.

Are there any known interacting partners of ARHGEF19 protein? 11/01/2018

Currently, there are no well-established interacting partners of ARHGEF19 protein. More research is required to identify and understand its protein-protein interactions.

Does ARHGEF19 protein have any known post-translational modifications? 08/28/2018

The presence of post-translational modifications (PTMs) on ARHGEF19 protein has not been extensively studied. However, it is plausible that the protein may undergo PTMs such as phosphorylation, acetylation, or ubiquitination, which can impact its stability, activity, or subcellular localization.

Are there any known homologs or related family members of ARHGEF19 protein? 06/15/2017

ARHGEF19 protein belongs to the Rho guanine nucleotide exchange factor (RhoGEF) family. It shares certain structural and functional similarities with other members of this family, including ARHGEF1, ARHGEF11, and ARHGEF25, which are implicated in various cellular processes.

Are there any therapeutic implications associated with ARHGEF19 protein? 10/30/2016

Currently, there are no known therapeutic implications directly linked to ARHGEF19 protein. However, further research on its function and potential interactions may reveal therapeutic targets in the future.

Are there any known alternative splice variants of ARHGEF19? 02/17/2016

Limited information is available regarding alternative splice variants of ARHGEF19 protein. Further investigations are required to determine if there are any alternative splicing isoforms and to understand their potential functional differences.

Customer Reviews (8)

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Reviews
04/12/2023

    An ARHGEF19 protein manufacturer that also offers related reagents such as antibodies or assay kits can streamline the research process.

    09/04/2020

      Its purity and consistency enable accurate and precise data analysis, ensuring the integrity of my research outcomes.

      04/27/2020

        This support could range from assisting with experimental design to offering advice on optimal protein handling and storage conditions.

        04/08/2020

          the ARHGEF19 protein's exceptional quality, reliability, and the manufacturer's unparalleled technical support make it a prime choice for researchers seeking to delve into the intricacies of angiogenesis, vascular development, and related fields.

          06/20/2018

            It can be effectively employed in in vitro and in vivo studies, offering insights into the intricate mechanisms underlying angiogenesis, lipid metabolism, and cardiovascular diseases.

            11/07/2017

              the manufacturer fosters scientific collaboration and knowledge sharing among researchers.

              08/28/2017

                One of the primary advantages of the ARHGEF19 protein is its versatility in various trial applications.

                10/27/2016

                  This guarantees a continuous and uninterrupted availability of the protein for researchers, eliminating concerns about potential shortages or delays.

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