ARHGEF3 Protein, Rho guanine nucleotide exchange factor (GEF) 3


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Official Full Name Rho guanine nucleotide exchange factor (GEF) 3
Background Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms ARHGEF3; Rho guanine nucleotide exchange factor (GEF) 3; rho guanine nucleotide exchange factor 3; DKFZP434F2429; exchange factor found in platelets and leukemic and neuronal tissues; XPLN; GEF3; RhoGEF protein; STA3; 59.8 kDA protein; ARHGEF 3; Exchange factor found in platelets and leukemic and neuronal tissues XPLN; FLJ98126; GEF 3; MGC118905; STA 3; exchange factor found in platelets and leukemic and neuronal tissues, XPLN
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ARHGEF3-786H Recombinant Human ARHGEF3 protein, GST-tagged Wheat Germ GST
    Human ARHGEF3-8731HCL Recombinant Human ARHGEF3 293 Cell Lysate HEK293 N/A
    Mouse ARHGEF3-1898M Recombinant Mouse ARHGEF3 Protein Mammalian Cell His
    Chicken ARHGEF3-2308C Recombinant Chicken ARHGEF3 Mammalian Cell His
    Zebrafish ARHGEF3-5258Z Recombinant Zebrafish ARHGEF3 Mammalian Cell His

    ARHGEF3 involved in several pathways and played different roles in them. We selected most pathways ARHGEF3 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, G alpha (12/13) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell death signalling via NRAGE, NRIF and NADE AATF; CASP2; NET1; TRIO; DCLRE1B; OBSCN; BCL2L11; ARHGEF1A; ARHGEF18; ARHGAP4A
    G alpha (12/13) signalling events TIAM2; ARHGEF18; FGD4; ARHGEF18A; ADRA1B; AKAP13; NET1; RHOB; ADRA1D; GNA13
    GPCR downstream signaling HRH3; GPRC6A; RGS10; QRFP; OR52J3; PROK2; TAC3; UTS2; CXCL13; PNOC
    NRAGE signals death through JNK ABR; ARHGEF18; NET1; ARHGAP4A; AATF; TIAM2; ARHGEF3; ARHGEF16; MCF2L; ECT2
    Regulation of RhoA activity FARP1; MCF2L; MYO9B; ARHGEF15; NET1; AKAP13; ABR; DEF6; ECT2; ARAP1
    Signal Transduction STRA6; ACKR4; QRFPR; ABCA4A; TAX1BP1; ADH8B; USP34; RCA2.1; OR4D2; RHOF
    Signaling by GPCR NMB; FGD4; OR4D2; GNA13B; OXGR1A.1; APLN; OR56A1; OBSCN; CXCR7B; GPR65

    ARHGEF3 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF3 itself. We selected most functions ARHGEF3 had, and list some proteins which have the same functions with ARHGEF3. You can find most of the proteins on our site.

    Function Related Protein
    Rho guanyl-nucleotide exchange factor activity FARP1; ALS2CL; PREX1; ARHGEF1B; PLEKHG6; PLEKHG7; FGD4; SOS1; ARHGEF7; RASGRF2B
    protein binding PRPF4; PAFAH1B3; RGS8; CSNK1G2; GPANK1; PSMB4; MIS18A; SATB1; RHOB; CASP14

    ARHGEF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF3.

    TRIM27; TRIM23; CEP70

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