Recombinant Human ARHGEF3 protein, GST-tagged

• Cat.No.: ARHGEF3-786H
• Product Overview: Human ARHGEF3 full-length ORF ( AAH99715.1, 1 a.a. - 324 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 63.4 kDa
• AA Sequence: MKLPCLSSYDSYCSNQVAAKALLDH KKQDHRVQDFLQRCLESPFSRKLDL WNFLDIPRSRLVKYPLLLREILRHT PNDNPDQQHLEEAINIIQGIVAEIN TKTGESECRYYKERLLYLEEGQKDS LIDSSRVVCCHGELKNNRGVKLHVF LFQEVLVITRAVTHNEQLCYQLYRQ PIPVKDLLLEDLQDGEVRLGGSLRG AFSNNERIKNFFRVSFKNGSQSQTH SLQANDTFNKQQWLNCIRQAKETVL CAAGQAGVLDSEGSFLNPTTGSREL QGETKLEQMDQSDSESDCSMDTSEV SLDCERMEQTDSSCGNSRHGESNV
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 [ Homo sapiens ]
• Official Symbol: ARHGEF3
• Synonyms: ARHGEF3; Rho guanine nucleotide exchange factor (GEF) 3; rho guanine nucleotide exchange factor 3; DKFZP434F2429; exchange factor found in platelets and leukemic and neuronal tissues; XPLN; GEF3; RhoGEF protein; STA3; 59.8 kDA protein; exchange factor found in platelets and leukemic and neuronal tissues, XPLN; FLJ98126; MGC118905; DKFZp434F2429
• Gene ID: 50650
• mRNA Refseq: NM_001128615
• Protein Refseq: NP_001122087
• MIM: 612115
• UniProt ID: Q9NR81