Recombinant Human ARHGEF3 protein, GST-tagged ARHGEF3-786H

Recombinant Human ARHGEF3 protein, GST-tagged

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Recombinant Human ARHGEF3 protein, GST-tagged

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Cat.No. : ARHGEF3-786H
Product Overview : Human ARHGEF3 full-length ORF ( AAH99715.1, 1 a.a. - 324 a.a.) recombinant protein with GST-tag at N-terminal.
Description : Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 63.4 kDa
AA Sequence : MKLPCLSSYDSYCSN QVAAKALLDHKKQDH RVQDFLQRCLESPFS RKLDLWNFLDIPRSR LVKYPLLLREILRHT PNDNPDQQHLEEAIN IIQGIVAEINTKTGE SECRYYKERLLYLEE GQKDSLIDSSRVVCC HGELKNNRGVKLHVF LFQEVLVITRAVTHN EQLCYQLYRQPIPVK DLLLEDLQDGEVRLG GSLRGAFSNNERIKN FFRVSFKNGSQSQTH SLQANDTFNKQQWLN CIRQAKETVLCAAGQ AGVLDSEGSFLNPTT GSRELQGETKLEQMD QSDSESDCSMDTSEV SLDCERMEQTDSSCG NSRHGESNV
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Figure :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 [ Homo sapiens ]
Official Symbol : ARHGEF3
Synonyms : ARHGEF3; Rho guanine nucleotide exchange factor (GEF) 3; rho guanine nucleotide exchange factor 3; DKFZP434F2429; exchange factor found in platelets and leukemic and neuronal tissues; XPLN; GEF3; RhoGEF protein; STA3; 59.8 kDA protein; exchange factor found in platelets and leukemic and neuronal tissues, XPLN; FLJ98126; MGC118905; DKFZp434F2429;
Gene ID : 50650
mRNA Refseq : NM_001128615
Protein Refseq : NP_001122087
MIM : 612115
UniProt ID : Q9NR81

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