atg7
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  • Official Full Name
  • ATG7 autophagy related 7 homolog (S. cerevisiae)
  • Background
  • This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes.
  • Synonyms
  • ATG7; ATG7 autophagy related 7 homolog (S. cerevisiae); GSA7; APG7L; APG7-LIKE; DKFZp434N0735; APG7 autophagy 7-like (S. cerevisiae); Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; hAGP7; Ubiquitin-activating enzyme E1-like protein; OTTHUMP00000160157; OTTHUMP00000207591; OTTHUMP00000207592; ubiquitin activating enzyme E1-like protein
Cat.#:Atg7-1524MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Atg7 Protein, His-tagged
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Cat.#:Atg7-1525MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Atg7 Protein, His-tagged
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Cat.#:APG7L-680HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human APG7L protein, GST-tagged
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Cat.#:ATG7-1076HTag:His
Source (Host):Baculovirus Sf21 Insect CellsSpecies:Human
Product nameRecombinant Human ATG7 Protein, His-tagged
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Cat.#:ATG7-127HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human full-length ATG7, GST-tagged
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Cat.#:ATG7-128HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ATG7, MYC/DDK-tagged
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Cat.#:ATG7-169HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ATG7, His-tagged
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Cat.#:ATG7-845RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ATG7 Protein
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Cat.#:ATG7-443RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ATG7 Protein, His-tagged
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Cat.#:ATG7-2305CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ATG7
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Cat.#:ATG7-8621HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ATG7 293 Cell Lysate
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Involved Pathway

Atg7 involved in several pathways and played different roles in them. We selected most pathways Atg7 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Atg7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
RNF138; MGC174857; ITGB1B.1; ASB4; KIF4A; MICA; UBE2V1; SIGLEC7; DYNC1I1; DYNLL2
Antigen processing: Ubiquitination &
TRIM41; RNF19B; SPSB1; MKRN1; ASB4; TPP2; RNF220; BLMH; UBE2J2; UBE2E3
Proteasome degradation
IWS1; UFL1; TRAF7; RNF123; ASB3; CMTM2A; FBXO17; ASB14; WSB1; TRIM63
Cellular responses to stress
IGFBP7; CBX8B; MAP1LC3C; SCMH1; CBX8A; RBB4L; UVRAG; EPAS1B; RRAGA; HIST3H2BB
Class I MHC mediated antigen processing &
RNF19B; WWP1; UBE2L6; ASB14; CMTM2A; SEC24A; RNF14; RNF25; RBCK1; HECTD3
presentation
RNF138; RNF182; PJA2; DTX3L; CD207; UBE2V2; RNF4; HECTD3; MKRN1; UBA5
Immune System
WASF2; SUGT1; IFITM2; TREML1; VPRBP; IgG3; KIF4; KIF11; OSBPL1A; BTR30
Macroautophagy
RB1CC1; ATG9B; ATG4A; UVRAG; AMBRA1A; DYNLL2B; AMBRA1B; ATG101; GABARAPL2; MAP1LC3B
Regulation of autophagy
IFNA2; IFNA5; ATG3; ULK1; INS2; IFNA1; IFNA16; IFNA17; IFNA21; INSB
Senescence and Autophagy
IL24; GABARAPL2; IGFBP5; AMBRA1; RB1CC1; RSL1D1; SLC39A3; ING2; FKBP8; IGFBP7

Protein Function

Atg7 has several biochemical functions, for example, Atg12 activating enzyme activity, Atg8 activating enzyme activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Atg7 itself. We selected most functions Atg7 had, and list some proteins which have the same functions with Atg7. You can find most of the proteins on our site.
Function
Related Protein
Function Atg12 activating enzyme activity
Related Protein ATG7
Function Atg8 activating enzyme activity
Related Protein ATG7
Function protein binding
Related Protein MED11; FIBCD1; HNRPLL; CCDC24; NCL; CEP350; CCDC11; ALG2; OSR2; HDAC2
Function protein homodimerization activity
Related Protein PLEKHB1; CACYBP; GPD1; BCL2; JUP; MTMR2; MCL1B; PTS; SLK; SFTPC
Function transcription factor binding
Related Protein INSIG2; MAFB; BCL10; HDAC4; RARA; TFDP1A; PAX2; PPID; MDFIC; CCND1
Function ubiquitin activating enzyme activity
Related Protein UBA6; SAE1; ATG7; UBA1; UBE1Y1; UBA7

Interacting Protein

Atg7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Atg7 here. Most of them are supplied by our site. Hope this information will be useful for your research of Atg7.
MAP1LC3B; GABARAP; GABARAPL2

Atg7 Related Articles

Okada, M; Oikawa, M; et al. Immunohistochemical assessment of ATG7, LC3, and p62 in ameloblastomas. JOURNAL OF ORAL PATHOLOGY & MEDICINE 43:606-612(2014).
Chen, M; Hong, MJ; et al. Essential role for autophagy in the maintenance of immunological memory against influenza infection. NATURE MEDICINE 20:507-514(2014).