ATP6V1B2 Protein, ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2


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Official Full Name ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
Background This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts.
Synonyms ATP6V1B2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2; ATP6B2, ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta polypeptide, 56/58kD, isoform 2 , ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B, isoform 2 , VPP3; V-type proton ATPase subunit B, brain isoform; HO57; VATB; Vma2; ATP6B1B2; ATP6B2; ATP6V1 B2; ATP6V1B 2; ATPase H+ transporting lysosomal 56/58kDa V1 subunit B isoform 2; ATPase H+ transporting lysosomal 56/58kDa V1 subunit B2; ATPase H+ transporting, lysosomal (vacuolar proton pump) beta polypeptide 56/58kD isoform 2; ATPase, H+ transporting, lysosomal V1 subunit B2; Endomembrane proton pump 58 kDa subunit; H+ transporting two sector ATPase; HO 57; V ATPase B2 subunit; V ATPase subunit B 2; V type proton ATPase subunit B, brain isoform; Vacuolar ATP synthase subunit B brain isoform; Vacuolar H+ ATPase 56000 subunit; Vacuolar H+ATPase B2; Vacuolar proton pump subunit B 2; VAT B2; VATB 2; VATB2; Vma 2; VPP 3; VPP3; OTTHUMP00000161707; V-ATPase B2 subunit; V-ATPase subunit B 2; H+ transporting two-sector ATPase; vacuolar H+-ATPase 56,000 subunit
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Atp6v1b2-671M Recombinant Mouse Atp6v1b2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human ATP6V1B2-1002H Recombinant Human ATP6V1B2 protein, GST-tagged Wheat Germ GST
    Human ATP6V1B2-10042H Recombinant Human ATP, His-tagged E.coli His
    Human ATP6V1B2-8583HCL Recombinant Human ATP6V1B2 293 Cell Lysate HEK293 N/A
    Mouse ATP6V1B2-2160M Recombinant Mouse ATP6V1B2 Protein Mammalian Cell His
    Rat ATP6V1B2-890R Recombinant Rat ATP6V1B2 Protein Mammalian Cell His
    Chicken ATP6V1B2-5562C Recombinant Chicken ATP6V1B2 Mammalian Cell His
    Zebrafish ATP6V1B2-9668Z Recombinant Zebrafish ATP6V1B2 Mammalian Cell His

    ATP6V1B2 involved in several pathways and played different roles in them. We selected most pathways ATP6V1B2 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V1B2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Oxidative phosphorylation ATP5I; NDUFS4; MT-ND1; NDUFS6; ATP6V1H; UQCRB; NDUFA5; ATP6V0E1; ATP6V1E1; ATP5O
    Metabolic pathways POLR3C; GCSH; ITPKB; MAN1A2; TYMP; CMBL; NDUFV1; MGAT3; PYCRL; CYP21A1
    Synaptic vesicle cycle UNC13A; RIMS1; ATP6V0E1; ATP6V1B1; ATP6V1H; ATP6V1E2; SLC17A6; CPLX4; DNM3; ATP6V1G1
    Collecting duct acid secretion ATP6V0C; ATP6V0E2; ATP4B; ATP6V1A; SLC4A1; CA2; ATP6V0A4; CLCNKB; ATP6V1D; ATP6V0E1
    Vibrio cholerae infection ATP6V1C2; ACTB; SEC61G; KDELR1; ATP6V1D; GNAS; TJP1; ATP6V1E1; ATP6V1H; TJP2
    Epithelial cell signaling in Helicobacter pylori infection GIT1; MAPK8; ATP6V1E1; MAPK9; MET; ATP6AP1; MAPK12; PLCG1; MAPK11; ATP6V1B2
    Rheumatoid arthritis ATP6V1F; ATP6V1A; ACP5; HLA-DRB5; HLA-DRB4; FOS; ATP6V1D; HLA-DRB3; HLA-DPA1; FLT1

    ATP6V1B2 has several biochemical functions, for example, ATP binding, hydrogen ion transmembrane transporter activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V1B2 itself. We selected most functions ATP6V1B2 had, and list some proteins which have the same functions with ATP6V1B2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding SLKA; MOS; BBS12; DYNC1H1; MYO5C; OBSCN; GTF2F2A; TARSL2; C9orf96; TRPM4
    hydrogen ion transmembrane transporter activity ATP6V0A1B; ATP6V0CB; ATP6V1AA; Atp5k; ATP5L; ATP6V0E2; ATP5G3A; ATP6V0CA; ATP5S; ATP5H
    protein binding WDR34; ZNF32; C1QTNF3; SHISA5; NEK9; SOCS2; WAPAL; PIANP; CORO1B; LEO1
    proton-transporting ATPase activity, rotational mechanism ATP6V0B; ATP6AP1; ATP6V0E; ATP5D; ATP6V0E1; ATP6V1B2; ATP6V1AA; ATP6AP1B; ATP6V0A1B; ATP5C1

    ATP6V1B2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V1B2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V1B2.

    TCF4; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; pi3p; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; 15-deoxy-delta(12,14; Ccdc9; ATP6AP2; A2M; FN1; PTPN1; Rab5c; Bmpr1a; ATP6V1A; Vps4b; RAB5C; RAB7A; RAB2A

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