ATXN7
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Official Full Name
ataxin 7
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Overview
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the pure cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes, and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] -
Synonyms
ATXN7; ataxin 7; SCA7; OPCA3; ADCAII; ataxin-7; spinocerebellar ataxia type 7 protein;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- E.Coli or Yeast
- HEK293
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Myc
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ATXN7-3690H | Recombinant Human ATXN7, His-tagged | E.Coli or Yeast | His | 892 | |
Human | ATXN7-917H | Recombinant Human ATXN7 protein, His&Myc-tagged | E.coli | His&Myc | 79-401aa | |
Human | ATXN7-301504H | Recombinant Human ATXN7 protein, GST-tagged | E.coli | GST | Met170-Arg335 | |
Mouse | ATXN7-2198M | Recombinant Mouse ATXN7 Protein | Mammalian Cell | His | ||
Mouse | ATXN7-903M | Recombinant Mouse ATXN7 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ATXN7-903M-B | Recombinant Mouse ATXN7 Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
- ATXN7 Related Articles
ATXN7 involved in several pathways and played different roles in them. We selected most pathways ATXN7 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATXN7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Chromatin modifying enzymes | SMYD2A;BRMS1;MSL1;PBRM1L;GATAD2AB;SMARCA4;RUVBL2;SMARCB1A;TADA1 |
Chromatin organization | PRDM16;RBBP4;SMARCA2;PHF15;EPC1;KDM3B;ACTL6A;TADA3;C20orf20 |
HATs acetylate histones | ANO9A;TAF6L;MBIP;BRD1;MORF4L2;RBB4L;MSL2A;YEATS4;KAT8 |
ATXN7 has several biochemical functions, for example, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATXN7 itself. We selected most functions ATXN7 had, and list some proteins which have the same functions with ATXN7. You can find most of the proteins on our site.
Function | Related Protein |
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chromatin binding | UBE2T;CAPNS2;PBX2;TCF7L1A;POLE;MEIS1;SMARCD1;RERE;HDAC4 |
protein binding | PPP1R2P9;CDH5;FKBPL;ASCC3;IL36RN;SNRPE;NUDCD2;CYP2S1;ATP5A1 |
ATXN7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATXN7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATXN7.
SORBS1; TAF10
- Q&As
- Reviews
Q&As (6)
Ask a questionThe ATXN7 protein consists of multiple functional domains, including multiple HEAT repeats, which may be involved in protein interactions and regulation of function.
ATXN7 protein is mainly located in the nucleus and participates in the regulation of gene transcription.
The expression and function of ATXN7 protein are affected by multiple regulatory mechanisms, including transcriptional regulation, post-translational modification, and protein-protein interaction.
In-depth study of the function and regulatory mechanism of ATXN7 protein will help to reveal the mechanism of spinocerebellar ataxia (SCA7) and provide new targets and strategies for the diagnosis and treatment of the disease.
The protein mutations are associated with the development of spinocerebellar ataxia (SCA7).
ATXN7 protein interacts with multiple proteins, including transcription factors, coactivators, and other regulatory proteins.
Customer Reviews (3)
Write a reviewBecause the extraordinary stability of ATXN7 under various conditions highlights its robustness and versatility.
Application range of ATXN7 is really wide, from the laboratory to the clinic, can see its figure, it is really rare.
This powerful biological activity of proteins combined with their high purity makes their experimental results extremely reliable, which is of great significance in the field of scientific research.
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