akap1
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  • Official Full Name
  • A kinase (PRKA) anchor protein 1
  • Background
  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment.
  • Synonyms
  • AKAP1; A kinase (PRKA) anchor protein 1; PRKA1; A-kinase anchor protein 1, mitochondrial; AKAP84; AKAP121; AKAP149; D AKAP1; dual specificity A kinase anchoring protein 1; PPP1R43; protein kinase anchoring protein 1; protein phosphatase 1; regulatory subunit 43; S AKAP84; SAKAP84; A kinase anchor protein; AKAP 149; AKAP; DAKAP1; Protein kinase A1; D-AKAP-1; A-kinase anchor protein 149 kDa; protein kinase A anchoring protein 1; spermatid A-kinase anchor protein 84; protein phosphatase 1, regulatory subunit 43; dual-specificity A-kinase anchoring protein 1; D-AKAP1
Cat.#:AKAP1-395HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AKAP1 Protein, GST-tagged
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Cat.#:AKAP1-9517HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKAP1, His-tagged
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Cat.#:AKAP1-1469MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse AKAP1 Protein
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Cat.#:Akap1-3019RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Akap1, His-tagged
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Cat.#:AKAP1-587RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AKAP1 Protein
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Cat.#:AKAP1-286RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey AKAP1 Protein, His-tagged
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Cat.#:AKAP1-8942HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human AKAP1 293 Cell Lysate
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Involved Pathway

AKAP1 involved in several pathways and played different roles in them. We selected most pathways AKAP1 participated on our site, such as Factors involved in megakaryocyte development and platelet production, G Protein Signaling Pathways, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Factors involved in megakaryocyte development and platelet production
BA2; KIF2C; KIF3A; KIF11; MAFF; DOCK11; KIF18A; HBD; D-AKAP2; ZFPM2A
G Protein Signaling Pathways
GNB5B; GNGT2A; AKAP10; GNB3B; AKAP5; AKAP13; GNA13; AKAP8; AKAP1; Akap3
Hemostasis
VPS45; DGKB; NADL1.1; AKAP1; GNA13; DOCK7; PDPN; CAP1; KIF4; MAFGB

Protein Function

AKAP1 has several biochemical functions, for example, RNA binding, beta-tubulin binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP1 itself. We selected most functions AKAP1 had, and list some proteins which have the same functions with AKAP1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein HSP90B1; WRAP53; NCBP1; RNASEL2; EIF4G2B; RAD51AP1; KHDC1; PCBP2; C14orf166; SUPV3L1
Function beta-tubulin binding
Related Protein GABARAP; RGS2; IFT74; SERPINB1A; UXT; SNCA; ARL8B; ARL8A; SLC6A2; GABARAPL1
Function microtubule binding
Related Protein S100A9; KIF1B; EZR; MID2; BIRC5; CDK5RAP2; PAFAH1B1; UXT; EML2; CRIPT
Function poly(A) RNA binding
Related Protein RPL4; RPS3A; C11orf68; BUD13; PPAN; STXBP1; DDX17; PKM; USP10; WBSCR22
Function protein binding
Related Protein C1orf216; ELP4; TMEM123; C1QTNF8; ERGIC2; FKBP7; FUBP3; SIGLEC8; ACMSD; UBE2O
Function protein complex scaffold
Related Protein AKAP6; KLHL17; CAPN3; WWC3; DISC1; SEPT2; CHCHD3; SLC9A3R1; CNOT1; SMARCD1
Function protein domain specific binding
Related Protein FOXA1; CBX3; HIST1H4L; RAB27A; ARL1; HIST1H4J; HIST1H4E; STX18; YWHAQA; PRKAR2B
Function protein kinase A regulatory subunit binding
Related Protein AKAP6; KCNQ1; ARFGEF2; AKAP9; ARFGEF1; RYR2; AKAP5; C2orf88; EZR; ACBD3
Function protein kinase binding
Related Protein MAP3K2; AKAP7; DCX; BCL10; CCNYL1; PPME1; TNIP2; STAP1; CD3E; CCNL1A
Function protein phosphatase 2B binding
Related Protein PPP3CB; BAD; SLC9A1; AKAP5; MYOZ2; SOD1; ATP2B4; AKAP1

Interacting Protein

AKAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP1.
PRKAR2A; PRKACA; Siah2; USP7; DYSF; PRKAR1A; p29991-pro_0000037941; MYCBP; 3',5'-cyclic amp; 2_aha_camp; 8-aha-camp

AKAP1 Related Articles

Sotgia, F; Whitaker-Menezes, D; et al. Mitochondria "fuel" breast cancer metabolism Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. CELL CYCLE 11:4390-4401(2012).
Reinton, N; Collas, P; et al. Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis. DEVELOPMENTAL BIOLOGY 223:194-204(2000).