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Alox12e

  • Official Full Name

    arachidonate lipoxygenase, epidermal

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Mouse
  • Rat
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse ALOX12E-1565M Recombinant Mouse ALOX12E Protein Mammalian Cell His
Mouse ALOX12E-482M Recombinant Mouse ALOX12E Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ALOX12E-482M-B Recombinant Mouse ALOX12E Protein Pre-coupled Magnetic Beads HEK293
Rat ALOX12E-635R Recombinant Rat ALOX12E Protein Mammalian Cell His
Rat ALOX12E-291R Recombinant Rat ALOX12E Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ALOX12E-291R-B Recombinant Rat ALOX12E Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

Alox12e involved in several pathways and played different roles in them. We selected most pathways Alox12e participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Alox12e were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arachidonic acid metabolismFAAH2A;CYP1A1;CYP4A12A;PLA2G2D;PTGS1;CYP2C45;PLA2G1B;LTA4H;FAM213B
Metabolic pathwaysPLA2G4A;ACMSD;PLA2G1B;RDH10B;ALOX12;ACSL3B;GMPPAA;NT5C2A;PLCH2
Serotonergic synapseHTR3E;HTR1B;SLC18A1;PLA2G4A;KCND2;GNG7;CYP2C50;GNB3;CYP2C54
Inflammatory mediator regulation of TRP channelsASIC2;PRKACB;MAPK8;TRPV2;IGF1;PPP1CB;MAP2K6;PRKCD;CYP2C39

Alox12e has several biochemical functions, for example, arachidonate 12-lipoxygenase activity, dioxygenase activity, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Alox12e itself. We selected most functions Alox12e had, and list some proteins which have the same functions with Alox12e. You can find most of the proteins on our site.

Function Related Protein
arachidonate 12-lipoxygenase activityALOX12;ALOX12B;ALOX15;ALOX12E
dioxygenase activityPTGS1;TDO2B;TDO2A;ASPHD1;BCO1;KDM4C;OGFOD2;HPDA;KDM4D
iron ion bindingCYP2Y3;HBE1;CYP3C4;CYP2AA1;HBB;CYP2E1;CYP7A1A;CYP2P8;ALOX5
metal ion bindingPVALB4;ZNF729;ZC3HAV1;ZFYVE9;HDAC7A;GTF3AB;ZDHHC14;NEK9;CHORDC1
oxidoreductase activityAIFM4;CYP3A41B;CYP1A2;ETFDH;SCDB;CYP4A14;SOD3A;SCCPDHB;DIO3
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenP4HA1B;ALOX8;ADOA;ALOX12;ALOX12B;ALOX5B.3;P4HA2;ADOB;P4HA3

Alox12e has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Alox12e here. Most of them are supplied by our site. Hope this information will be useful for your research of Alox12e.

  • Q&As
  • Reviews

Q&As (15)

Ask a question
What are the detection methods for ALOX12E? 01/06/2023

The detection methods of ALOX12E include immunohistochemistry, real-time fluorescence quantitative PCR, etc.

What is the role of ALOX12E in the effect of estrogen on the skin? 11/29/2022

ALOX12E may be involved in the regulation of the effects of estrogen on the skin, but the specific role needs to be studied.

What is the function of ALOX12E? 09/27/2022

ALOX12E catalyzes the oxidation of arachidonic acid in epidermal cells to form 12-hydroxyarachidonic acid, thus participating in the keratinization process and skin barrier formation.

What diseases is overexpression of ALOX12E associated with? 08/16/2022

Overexpression of ALOX12E is associated with psoriasis, atopic dermatitis, and lupus erythematosus.

What is the role of ALOX12E in immune response? 09/04/2021

This protein may be involved in the regulation of skin immune response, but its specific role needs further study.

Which chromosome is the ALOX12E gene located on? 08/09/2021

The gene for ALOX12E is located on human chromosome 17.

How does the consequences of a point mutation in ALOX12E? 05/26/2021

Point mutations in ALOX12E can lead to skin disorders such as abnormal keratosis and ichthyosis.

Under what circumstances is ALOX12E activated? 10/22/2020

It may be activated in response to cell stimulation, such as trauma.

What are the inhibitors of ALOX12E? 09/04/2020

Inhibitors of ALOX12E include arabidopsis, procainamide, etc.

What is the signaling pathway of ALOX12E? 08/31/2020

The ALOX12E signaling pathway is mainly realized through the MAPK signaling pathway.

Which role of ALOX12E in apoptosis? 06/06/2020

ALOX12E may play an anti-apoptotic role in cell apoptosis.

Is there a relationship between ALOX12E and skin cancer? 10/20/2019

ALOX12E has been linked to skin cancer, and its inhibitors can be used to treat skin cancer.

Which diseases are ALOX12E abnormalities associated with? 09/10/2019

Abnormalities in ALOX12E have been linked to conditions such as psoriasis, atopic dermatitis and dry skin.

In which tissues is ALOX12E expressed? 08/14/2019

ALOX12E is mainly expressed in the skin and cornea.

What is the regulation of ALOX12E expression? 07/29/2019

The expression of ALOX12E is affected by many factors such as extracellular calcium ion concentration, extracellular oxygen partial pressure, and cytokines.

Customer Reviews (3)

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Reviews
03/19/2021

    When desensitize specific allergens, ALOX12E has a strong potential.

    03/03/2020

      ALOX12E showed good compatibility and stability with various excipients.

      11/10/2019

        The pharmacodynamic parameters of ALOX12E were better.

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