Alox12e
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Official Full Name
arachidonate lipoxygenase, epidermal
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Mouse
- Rat
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Mouse | ALOX12E-1565M | Recombinant Mouse ALOX12E Protein | Mammalian Cell | His | ||
Mouse | ALOX12E-482M | Recombinant Mouse ALOX12E Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ALOX12E-482M-B | Recombinant Mouse ALOX12E Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ALOX12E-635R | Recombinant Rat ALOX12E Protein | Mammalian Cell | His | ||
Rat | ALOX12E-291R | Recombinant Rat ALOX12E Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | ALOX12E-291R-B | Recombinant Rat ALOX12E Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
Alox12e involved in several pathways and played different roles in them. We selected most pathways Alox12e participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Alox12e were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Arachidonic acid metabolism | FAAH2A;CYP1A1;CYP4A12A;PLA2G2D;PTGS1;CYP2C45;PLA2G1B;LTA4H;FAM213B |
Metabolic pathways | PLA2G4A;ACMSD;PLA2G1B;RDH10B;ALOX12;ACSL3B;GMPPAA;NT5C2A;PLCH2 |
Serotonergic synapse | HTR3E;HTR1B;SLC18A1;PLA2G4A;KCND2;GNG7;CYP2C50;GNB3;CYP2C54 |
Inflammatory mediator regulation of TRP channels | ASIC2;PRKACB;MAPK8;TRPV2;IGF1;PPP1CB;MAP2K6;PRKCD;CYP2C39 |
Alox12e has several biochemical functions, for example, arachidonate 12-lipoxygenase activity, dioxygenase activity, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Alox12e itself. We selected most functions Alox12e had, and list some proteins which have the same functions with Alox12e. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
arachidonate 12-lipoxygenase activity | ALOX12;ALOX12B;ALOX15;ALOX12E |
dioxygenase activity | PTGS1;TDO2B;TDO2A;ASPHD1;BCO1;KDM4C;OGFOD2;HPDA;KDM4D |
iron ion binding | CYP2Y3;HBE1;CYP3C4;CYP2AA1;HBB;CYP2E1;CYP7A1A;CYP2P8;ALOX5 |
metal ion binding | PVALB4;ZNF729;ZC3HAV1;ZFYVE9;HDAC7A;GTF3AB;ZDHHC14;NEK9;CHORDC1 |
oxidoreductase activity | AIFM4;CYP3A41B;CYP1A2;ETFDH;SCDB;CYP4A14;SOD3A;SCCPDHB;DIO3 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | P4HA1B;ALOX8;ADOA;ALOX12;ALOX12B;ALOX5B.3;P4HA2;ADOB;P4HA3 |
Alox12e has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Alox12e here. Most of them are supplied by our site. Hope this information will be useful for your research of Alox12e.
- Q&As
- Reviews
Q&As (15)
Ask a questionThe detection methods of ALOX12E include immunohistochemistry, real-time fluorescence quantitative PCR, etc.
ALOX12E may be involved in the regulation of the effects of estrogen on the skin, but the specific role needs to be studied.
ALOX12E catalyzes the oxidation of arachidonic acid in epidermal cells to form 12-hydroxyarachidonic acid, thus participating in the keratinization process and skin barrier formation.
Overexpression of ALOX12E is associated with psoriasis, atopic dermatitis, and lupus erythematosus.
This protein may be involved in the regulation of skin immune response, but its specific role needs further study.
The gene for ALOX12E is located on human chromosome 17.
Point mutations in ALOX12E can lead to skin disorders such as abnormal keratosis and ichthyosis.
It may be activated in response to cell stimulation, such as trauma.
Inhibitors of ALOX12E include arabidopsis, procainamide, etc.
The ALOX12E signaling pathway is mainly realized through the MAPK signaling pathway.
ALOX12E may play an anti-apoptotic role in cell apoptosis.
ALOX12E has been linked to skin cancer, and its inhibitors can be used to treat skin cancer.
Abnormalities in ALOX12E have been linked to conditions such as psoriasis, atopic dermatitis and dry skin.
ALOX12E is mainly expressed in the skin and cornea.
The expression of ALOX12E is affected by many factors such as extracellular calcium ion concentration, extracellular oxygen partial pressure, and cytokines.
Customer Reviews (3)
Write a reviewWhen desensitize specific allergens, ALOX12E has a strong potential.
ALOX12E showed good compatibility and stability with various excipients.
The pharmacodynamic parameters of ALOX12E were better.
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