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  • Official Full Name
  • BCL2-associated agonist of cell death
  • Background
  • The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]
  • Synonyms
  • BAD; BCL2-associated agonist of cell death; BBC2; BCL2L8; bcl2 antagonist of cell death; bcl2-L-8; BCL2-binding protein; bcl-2-like protein 8; BCL2-binding component 6; bcl-2-binding component 6; BCL-X/BCL-2 binding protein; BCL2-antagonist of cell death protein; bcl-XL/Bcl-2-associated death promoter;
Cat.#:BAD-564HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAD Protein, His-tagged
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Cat.#:BAD-048HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BAD protein, GST-tagged
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Cat.#:BAD-168HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human v protein, His-tagged
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Cat.#:BAD-26296THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAD
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Cat.#:BAD-26298THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human BAD
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Cat.#:BAD-6973HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human BAD, GST-tagged
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Cat.#:BAD-2269MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BAD Protein
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Cat.#:BAD-931RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BAD Protein
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Cat.#:BAD-505RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey BAD Protein, His-tagged
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Cat.#:BAD-1433HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human BCL2-associated Agonist Of Cell Death, GST-tagged
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Cat.#:BAD-82HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2-associated Agonist Of Cell Death
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Cat.#:BAD-8529HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human BAD 293 Cell Lysate
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Involved Pathway

BAD involved in several pathways and played different roles in them. We selected most pathways BAD participated on our site, such as ErbB signaling pathway, Ras signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
PIK3R2; CAMK2D1; TGFA; BTC; PRKCBB; SHC4; HRAS; ERBB2; MAPK8A; ERBB3B
Ras signaling pathway
PLA1A; MAP2K1; RRAS; FGF2; FGF8; GNB2; LAT; PLCG2; GRIN2B; CDC42
cGMP-PKG signaling pathway
CREB3L1; INS1; ATP2A2; GNAI3; MEF2D; PRKCE; PPP1R12A; CREB5; RHOA; PPP1CA
cAMP signaling pathway
PTGER3; FOS; PLCE1; HTR1E; ATP1B2; ATP1A3; PDE4B; GLI1; SLC9A1; HTR1A
PIK-Akt signaling pathway
IFNA8; IKBKG; IL2RA; IRS1; TCL1; PIK3CA; INS2; ITGAV; ITGA5; FASLG
Apoptosis
Fasl; PIK3CD; PIK3R5; HIST1H1D; CDK5RAP2; GZMF; IRAK4; DYNLL2; ENDOG; IRF2A
VEGF signaling pathway
PIK3R2; HRASA; CASP9; RAC3; PRKCBB; MAPK3; PLA2G4D; PRKCB; PLCG1; RAC1A
Focal adhesion
PAK3; RAP1B; SEPP1; PDGFC; VASPA; COL6A6; MYLK; PRKCBA; FN1A; MYLPF
Neurotrophin signaling pathway
PIK3R5; PRDM4; CALM2; PSEN2; RAC1; RPS6KA6; RPS6KA1; CAMK2A; BAD; PIK3R2
Insulin signaling pathway
PIK3CA; MAPK8A; INPPL1A; FBP1; PHKB; PTPRFB; RAPGEF1; PRKACAA; CALM4; TSC2
Thyroid hormone signaling pathway
SLC16A2; PLCB2; ESR1; MAPK1; ATP1B4; NRAS; ITGB3; STAT1; SLC9A1; PIK3CA
Alzheimers disease
ATP5A1; PPP3R1; CASP12; NDUFAB1; NDUFB5; CALML5; ATP5B; UQCR11; NDUFS2; NDUFA7
Amyotrophic lateral sclerosis (ALS)
CASP1; MAPK11; NOS1; DERL1; ALS2; GRIN1; GRIN2A; NEFL; PPP3CA; NEFH
Toxoplasmosis
TYK2; IFNGR1; PIK3R2; TGFB3; HSPA1L; PIK3R3; HSPA8; CD40; PDPK1; BCL2
Tuberculosis
IFNA8; TGFB2; HLA-DMA; FCGR3A; CALML5; ITGB2; MAPK8; NFYC; PPP3R1; Itgam&Itgb2
Hepatitis C
PPP2R2A; IFIT1; IKBKG; CLDN15; MAPK8; CLDN17; CLDN1; TRAF2; TRP53; NFKBIA
Hepatitis B
TGFBR1; FOS; PIK3R5; IRF3; TGFB2; STAT6; CCND1; STAT5B; IFNA17; TP53
Pathways in cancer
WNT16; BIRC7; PLCB4; ABL1; LAMB4; HSP90AA1; APC2; DAPK3; APC; ROCK2
Viral carcinogenesis
RELA; TP53; RBPJL; HIST1H4M; GTF2E2; HLA-G; HDAC11; BAK1; CCND3; PKM2
Colorectal cancer
MAPK1; MSH2; RAC2; AXIN2; PIK3CB; BAX; RAF1; Casp3; RALGDS; CASP9
Pancreatic cancer
IKBKB; TGFB1; BRAF; MAPK1; RALGDS; STAT1; SMAD4; RELA; BRCA2; MAPK8
Endometrial cancer
PIK3CB; AXIN1; ERBB2; APC; CTNNA3; MAPK3; PIK3CG; ILK; TP53; ELK1
Prostate cancer
NFKB1; BCL2; MDM2; INS1; TGFA; NDRG1; HRAS; GRB2; INS; Ar
Melanoma
FGF4; PDGFRA; FGFR1; MDM2; PIK3CD; FGF19; PIK3CG; FGF14; HRAS; PIK3R2
Chronic myeloid leukemia
PIK3R2; CRK; RB1; CCND1; SHC1; SMAD3; IKBKB; BRAF; CBL; PIK3CA
Acute myeloid leukemia
JUP; MAPK1; BAD; PIK3CA; CCNA1; GRB2; IKBKB; PPARD; MTOR; RUNX1T1
Non-small cell lung cancer
SOS1; NRAS; EML4; RASSF1; PLCG2; RARB; PDPK1; MAPK1; BRAF; PIK3R1

Protein Function

BAD has several biochemical functions, for example, cysteine-type endopeptidase activator activity involved in apoptotic process, lipid binding, phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAD itself. We selected most functions BAD had, and list some proteins which have the same functions with BAD. You can find most of the proteins on our site.
Function
Related Protein
Function cysteine-type endopeptidase activator activity involved in apoptotic process
Related Protein NLRP12; PYCARD; CASP1; CTSC; BAD; BCL2L13; CTSH; MAPK9; NOD1; NLRP1
Function lipid binding
Related Protein APODA.2; CLINT1; STARD13; FABP1B.1; PSAP; AP2M1B; CPTP; APOA5; PLTP; STARD10
Function phospholipid binding
Related Protein NBEAA; STAP1; NBEA; PTAFR; SEC14L2; MTAP1B; APOA5; PSD4; APOE; F3
Function protein binding
Related Protein CNTF; INHBA; SEMG2; ARAP1; EDC4; NEIL2; CDC42; SRM; CYCS; FBN2
Function protein heterodimerization activity
Related Protein TOP2B; IRAK1; UGT1A7; EGFR; TAP1; FLOT2; HIST1H3H; PRMT8; MEF2C; H2BFWT
Function protein kinase B binding
Related Protein CDC37; RARA; TRAF6; PDE3B; APPL1; BCL10; PINK1; ANKRD2; BAD; CCDC88A
Function protein kinase binding
Related Protein MAP3K13; RPTOR; MAG; MAP3K12; CCNL1B; NR4A3; FAM83B; CAMK2N2; PDPK1; MAPT
Function protein phosphatase 2B binding
Related Protein ATP2B4; MYOZ2; PPP3CB; AKAP5; SOD1; BAD; SLC9A1; AKAP1

Interacting Protein

BAD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAD here. Most of them are supplied by our site. Hope this information will be useful for your research of BAD.
BCL2L1; BCL2; BCL2L1

BAD Related Articles

Gamez, C; Zafra, MP; et al. Simulated gastrointestinal digestion reduces the allergic reactivity of shrimp extract proteins and tropomyosin. FOOD CHEMISTRY 173:475-481(2015).
Omar, AAH; Haglund, C; et al. MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 119:459-467(2015).

BAD Related Gene Family

BCL2 Gene Family