bad
Share
  • Official Full Name
  • BCL2-associated agonist of cell death
  • Background
  • The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]
  • Synonyms
  • BAD; BCL2-associated agonist of cell death; BBC2; BCL2L8; bcl2 antagonist of cell death; bcl2-L-8; BCL2-binding protein; bcl-2-like protein 8; BCL2-binding component 6; bcl-2-binding component 6; BCL-X/BCL-2 binding protein; BCL2-antagonist of cell death protein; bcl-XL/Bcl-2-associated death promoter;
Cat.#:BAD-564HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAD Protein, His-tagged
+Inquiry
Cat.#:BAD-048HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BAD protein, GST-tagged
+Inquiry
Cat.#:BAD-168HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human v protein, His-tagged
+Inquiry
Cat.#:BAD-26296THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAD
+Inquiry
Cat.#:BAD-26298THTag:
Source (Host):Species:Human
Product nameRecombinant Human BAD
+Inquiry
Cat.#:BAD-6973HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human BAD, GST-tagged
+Inquiry
Cat.#:BAD-2269MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BAD Protein
+Inquiry
Cat.#:BAD-931RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BAD Protein
+Inquiry
Cat.#:BAD-505RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey BAD Protein, His-tagged
+Inquiry
Cat.#:BAD-1433HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human BCL2-associated Agonist Of Cell Death, GST-tagged
+Inquiry
Cat.#:BAD-82HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2-associated Agonist Of Cell Death
+Inquiry
Cat.#:BAD-8529HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BAD 293 Cell Lysate
+Inquiry

Involved Pathway

BAD involved in several pathways and played different roles in them. We selected most pathways BAD participated on our site, such as ErbB signaling pathway, Ras signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
MAPK8B; GRB2; HRASB; MAP2K2B; CBLB; PLCG2; MAPK1; MAP2K7; NRG1; PAK2
Ras signaling pathway
FGF13; FGFR1; SOS1; RAB5C; RASSF1; CALM3; PRKACB; RHOA; PLA2G4C; GNG5
cGMP-PKG signaling pathway
ATP2B1; AKT1; PDE3A; PPP3R2; RAF1; PIK3CD; BDKRB2; PPIF; NFATC2; GUCY1A3
cAMP signaling pathway
GLP1R; ATP1A2; ROCK1; LIPE; RAC3; CAMK4; NFATC1; FXYD1; GRIA2; CNGA1
PIK-Akt signaling pathway
IRS1; TRP53; IFNA12; PIK3CA; PPP2R3A; TLR2; MTCP1; THBS3; PKN2; TNXB
Apoptosis
GAS2; CFLAR; BID; YWHAQ; SATB1; PLEC; STK26; CASP12; PKP1; CAPN1A
VEGF signaling pathway
PRKCBA; PRKCG; MAPKAPK3; SHC2; MAPK3; MAPK14A; PTGS2; BADB; PLA2G4C; MAPK12
Focal adhesion
IGF1; SRC; RAC1B; MAPK8B; PDGFC; PDGFAB; PTEN; ARHGAP35; PXNA; COL2A1A
Neurotrophin signaling pathway
MAP3K5; NTRK2; MAPK10; CAMK2A; NGFR; MAPK12; AKT2; IRAK2; PSEN2; CALM3
Insulin signaling pathway
SREBF1; CALM3A; TRIP10; SOCS1; PRKAR2AB; HRAS; GSK3B; PRKAR2B; MAPK10; SOCS2
Thyroid hormone signaling pathway
PRKACB; NOTCH4; PRKCA; ATP1B3; ATP1A1; PLCZ1; MED30; MED13; MTOR; PIK3CA
Alzheimers disease
ADAM10; PPP3CC; NDUFA4; Atp5g2; RYR3; NDUFS1; LRP1; ATP5O; ATP5J; NDUFB3
Amyotrophic lateral sclerosis (ALS)
TNFRSF1A; ALS2; TOMM40L; TP53; MAPK14; NEFH; BAX; Casp3; DAXX; GRIA2
Toxoplasmosis
LDLR; PIK3R1; BIRC2; ITGA6; LY96; HLA-DPB1; IL12B; NFKB1; PPIF; MAPK10
Tuberculosis
CASP10; NFYB; MAPK3; ATP6V0D1; CARD9; MYD88; IFNA1; CAMK2A; TLR4; ITGAX
Hepatitis C
CLDN9; PPP2R2B; IFNA10; EIF3E; NRAS; IRF3; CLDN20; PIK3R2; PPARA; RNASEL
Hepatitis B
DDX58; PCNA; CASP12; IKBKG; RB1; IL-8; IL6; STAT4; CREB3L3; CYCS
Pathways in cancer
FGF6; GNB4; PDGFRB; TCF7L2; GNB2; RET; SMAD3; FASLG; SMAD4; FZD3
Viral carcinogenesis
PSMC1; CREB3L1; HIST1H2BD; KAT2B; PRKACB; RBL1; MAPKAPK2; UBE3A; HDAC3; DLG1
Colorectal cancer
SMAD2; TGFBR2; TCF7; PIK3R3; RALGDS; PIK3CG; SMAD3; MAPK1; DCC; APC
Pancreatic cancer
TGFB3; BRAF; KRAS; STAT3; PIK3R3; TGFA; PIK3CD; PIK3CA; VEGFA; IKBKB
Endometrial cancer
TCF7; PIK3R5; ARAF; PIK3R3; ILK; APC; GRB2; PIK3CB; CASP9; KRAS
Prostate cancer
PDGFD; MAPK1; MAP4K1; RELA; PDGFRB; SMARCA4; PIK3R1; NDRG1; GSTP1; FGFR2
Melanoma
FGF8; PIK3R5; BRAF; FGF17; TRP53; NRAS; IGF1; FGF4; PIK3R3; FGFR1
Chronic myeloid leukemia
MAP2K2; MAP2K1; PIK3R1; HRAS; TGFB3; ARAF; CRKL; SOS1; IKBKB; RB1
Acute myeloid leukemia
IKBKG; RPS6KB2; MAPK3; HRAS; FLT3; STAT3; PIK3R2; SFPI1; SPI1; STAT5A
Non-small cell lung cancer
ALK; NRAS; BRAF; PIK3CA; RASSF1; AKT1; SOS1; EML4; PIK3R5; KRAS

Protein Function

BAD has several biochemical functions, for example, cysteine-type endopeptidase activator activity involved in apoptotic process, lipid binding, phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAD itself. We selected most functions BAD had, and list some proteins which have the same functions with BAD. You can find most of the proteins on our site.
Function
Related Protein
Function cysteine-type endopeptidase activator activity involved in apoptotic process
Related Protein BCL2L13; NOD1; CTSC; CARD8; MAPK9; RPS27L; NLRP1; CASP1; GNB2L1; NLRP12
Function lipid binding
Related Protein BPIFB6; Fert2; PACSIN3; AP2M1; AMER2; STARD6; DNM1L; FABP11A; PAQR7B; PSAP
Function phospholipid binding
Related Protein PACSIN1; PLEKHA3; OSBPL1A; PAFAH2; AGAP1; SMURF1; PON1; PICALMB; FABP1; APOC3
Function protein binding
Related Protein CAND1; BRD9; PCP4; STOX1; CCDC59; CEP57L1; NOLC1; COX8A; PRSS2; CTDSP1
Function protein heterodimerization activity
Related Protein NEUROD1; POLE4; TCF3A; VAPB; CEBPA; RALGAPA2; TENM1; CLCF1; TCF4; CHRNB2
Function protein kinase B binding
Related Protein PDE3B; ANKRD2; CCDC88A; CDC37; APPL1; TRAF6; RARA; PINK1; BCL10; BAD
Function protein kinase binding
Related Protein KIF11; RELA; CDK5RAP2; RPS3; RFFL; STX1B; MAP2K7; PRKAG3; GRB2; KCNH1
Function protein phosphatase 2B binding
Related Protein SOD1; SLC9A1; PPP3CB; AKAP1; ATP2B4; MYOZ2; BAD; AKAP5

Interacting Protein

BAD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAD here. Most of them are supplied by our site. Hope this information will be useful for your research of BAD.
BCL2L1; BCL2; BCL2L1

BAD Related Articles

Gamez, C; Zafra, MP; et al. Simulated gastrointestinal digestion reduces the allergic reactivity of shrimp extract proteins and tropomyosin. FOOD CHEMISTRY 173:475-481(2015).
Omar, AAH; Haglund, C; et al. MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 119:459-467(2015).

BAD Related Gene Family

BCL2 Gene Family