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  • Official Full Name
  • BCL2-associated agonist of cell death
  • Background
  • The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]
  • Synonyms
  • BAD; BCL2-associated agonist of cell death; BBC2; BCL2L8; bcl2 antagonist of cell death; bcl2-L-8; BCL2-binding protein; bcl-2-like protein 8; BCL2-binding component 6; bcl-2-binding component 6; BCL-X/BCL-2 binding protein; BCL2-antagonist of cell death protein; bcl-XL/Bcl-2-associated death promoter;
Cat.#:BAD-564HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAD Protein, His-tagged
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Cat.#:BAD-048HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BAD protein, GST-tagged
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Cat.#:BAD-168HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human v protein, His-tagged
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Cat.#:BAD-26296THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAD
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Cat.#:BAD-26298THTag:
Source (Host):Species:Human
Product nameRecombinant Human BAD
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Cat.#:BAD-6973HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human BAD, GST-tagged
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Cat.#:BAD-2269MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BAD Protein
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Cat.#:BAD-931RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BAD Protein
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Cat.#:BAD-505RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey BAD Protein, His-tagged
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Cat.#:BAD-1433HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human BCL2-associated Agonist Of Cell Death, GST-tagged
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Cat.#:BAD-82HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2-associated Agonist Of Cell Death
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Cat.#:BAD-8529HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BAD 293 Cell Lysate
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Involved Pathway

BAD involved in several pathways and played different roles in them. We selected most pathways BAD participated on our site, such as ErbB signaling pathway, Ras signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
NRG2; GRB2; GAB1; PIK3CG; MTOR; GRB2B; SRC; ARAF; ERBB4; PLCG2
Ras signaling pathway
FGF19; RGL2; FGF16; RRAS2; KIT; AKT2; FLT4; FLT1; REL; GNG8
cGMP-PKG signaling pathway
ATP1A3; NOS3; SLC25A6; INS; RHOA; VASP; MYH7; ROCK2; ATP1B3; GUCY1A3
cAMP signaling pathway
PDE3A; PAK1; NPY; GRIN2A; GHSR; PDE4B; FFAR2; PTGER2; CNGA2; GRIA4
PIK-Akt signaling pathway
IKBKG; GHR; FGF12; LPAR4; SPP1; IFNA21; NRAS; MTOR; G6PC3; FGF9
Apoptosis
AKT2L; STK24A; BIRC2; CAPN2; BIRC8; CASP12; BNIP3L; CASP3B; MYD88; AKT2
VEGF signaling pathway
MAPKAPK2; AKT3A; HRASB; PPP3R2; SRC; VEGFAA; PTGS2A; RAC3; AKT2L; MAPK14A
Focal adhesion
CAV1; ITGB7; CDC42L; PPP1R12A; LAMA5; AKT1; ACTN1; BADB; PIK3R2; PPP1R12C
Neurotrophin signaling pathway
PIK3R3; RAPGEF1; NFKBIB; TP53; MAPK1; ARHGDIA; MAPK13; MAPK12; NFKB1; PIK3R5
Insulin signaling pathway
SOCS1A; PHKB; INSB; HK2; FLOT2; SREBF1; SH2B2; CALM4; FOXO1B; MKNK2A
Thyroid hormone signaling pathway
PLCE1; PIK3CB; ACTG1; NRAS; ESR1; GSK3B; PRKCA; SLC2A1; TBC1D4; WNT4
Alzheimers disease
ATP5B; NDUFC1; GNAQ; HSD17B10; SNCA; SDHB; ADAM17; CAPN2; ATP5H; ATP5G3
Amyotrophic lateral sclerosis (ALS)
GRIN1; TNF; MAP2K3; GRIA1; APAF1; CCS; RAC1; MAPK14; MAPK12; TOMM40L
Toxoplasmosis
LAMA3; MAPK9; MAPK12; MAPK1; HLA-DOB; HLA-DMA; NFKBIA; BIRC7; LAMA5; IFNG
Tuberculosis
CALM4; CORO1A; PMAP-36; CEBPG; IFNA10; CAMK2B; MAPK11; IFNA12; STAT1; SRC
Hepatitis C
IFIT1; TRAF2; PPP2R1A; STAT2; PIK3CA; PIK3CD; OAS2; IFNA14; IL-8; PIK3CB
Hepatitis B
EGR3; PCNA; MAPK10; CASP10; CREB3L1; BAX; FAS; MAP3K1; IFIH1; IFNA17
Pathways in cancer
TGFB2; LAMB2; GNB2; WNT16; EGLN1; FGF5; WNT8A; ABL1; CYCS; PRKACB
Viral carcinogenesis
H2BFWT; GTF2H2C; RELA; HIST1H2BN; GTF2B; UBR4; PSMC1; MRPS18B; GTF2H4; POLB
Colorectal cancer
TCF7L2; DCC; TCF7; CYCS; MLH1; SMAD3; PIK3CD; RAF1; MAPK8; PIK3R3
Pancreatic cancer
BAD; RAF1; RELA; TGFB2; IKBKG; RB1; PLD1; RAC1; RALGDS; TGFA
Endometrial cancer
ELK1; CTNNA3; PTEN; HRAS; PIK3R1; TCF7; PDPK1; MAPK1; AKT1; AXIN2
Prostate cancer
EP300; FOXA1; GSK3B; CCNE1; MAPK1; PIK3CD; NOXA1; IKBKB; MAP2K1; SPINK1
Melanoma
PDGFD; IGF1R; PIK3CA; NRAS; PDGFRB; PIK3R3; AKT2; MAP2K1; AKT1; FGF6
Chronic myeloid leukemia
CBL; STAT5B; MAPK1; MAP2K1; CRK; SMAD3; TGFBR2; HRAS; BCL2L1; CTBP2
Acute myeloid leukemia
CEBPA; PIK3R3; SOS1; STAT5B; PIK3CG; ZBTB16; FLT3; MAP2K1; STAT5A; MAPK3
Non-small cell lung cancer
PIK3R5; MAP2K1; PIK3R3; RXRB; PDPK1; CCND1; TRP53; PRKCB; TGFA; BAD

Protein Function

BAD has several biochemical functions, for example, cysteine-type endopeptidase activator activity involved in apoptotic process, lipid binding, phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAD itself. We selected most functions BAD had, and list some proteins which have the same functions with BAD. You can find most of the proteins on our site.
Function
Related Protein
Function cysteine-type endopeptidase activator activity involved in apoptotic process
Related Protein PYCARD; NLRP1; APAF1; CTSH; BCL2L13; CASP1; NLRP12; CTSC; GNB2L1; BAD
Function lipid binding
Related Protein CYTH2; HDLBP; CHMP4A; LIPF; UNC119; ACBD6; DBI; PACSIN1B; APOL2; RBP7B
Function phospholipid binding
Related Protein ANXA9; BAD; CPS1; PACSIN1; DGKA; MYOF; BIN2; SPTB; APOC3; GLTPD1
Function protein binding
Related Protein ARMC2; RNF165; TUFM; WDHD1; LURAP1; RPF1; MPPE1; VDAC2; ARPM1; HTR1A
Function protein heterodimerization activity
Related Protein SRY; BRAF; SOX32; SYT16; VAPB; NR4A1; ITGB1A; NOTCH1; VEGFB; HIST1H2BA
Function protein kinase B binding
Related Protein PDE3B; RARA; APPL1; ANKRD2; BCL10; TRAF6; PINK1; CDC37; CCDC88A; BAD
Function protein kinase binding
Related Protein E2F1; RICTOR; CDK5; DUSP3; CCNT2A; TNNI3; KAT2B; AKAP1; SLC12A5; CCNT2B
Function protein phosphatase 2B binding
Related Protein BAD; SLC9A1; AKAP5; SOD1; ATP2B4; MYOZ2; AKAP1; PPP3CB

Interacting Protein

BAD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAD here. Most of them are supplied by our site. Hope this information will be useful for your research of BAD.
BCL2L1; BCL2; BCL2L1

BAD Related Articles

Gamez, C; Zafra, MP; et al. Simulated gastrointestinal digestion reduces the allergic reactivity of shrimp extract proteins and tropomyosin. FOOD CHEMISTRY 173:475-481(2015).
Omar, AAH; Haglund, C; et al. MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 119:459-467(2015).

BAD Related Gene Family

BCL2 Gene Family