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Official Full Name B-cell CLL/lymphoma 10
Background This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Synonyms BCL10; B-cell CLL/lymphoma 10; CLAP; mE10; CIPER; c-E10; CARMEN
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BCL10-1016H Recombinant Human B-cell CLL/lymphoma 10 Sf9 Insect Cell N/A
    Human BCL10-141H Recombinant Human BCL10 Protein, GST-tagged Wheat Germ GST
    Human BCL10-16H Recombinant Human BCL10, His-tagged E.coli His
    Human BCL10-8490HCL Recombinant Human BCL10 293 Cell Lysate HEK293 N/A
    Human BCL10-8496H Recombinant Human BCL10, His-tagged Sf21 Insect Cell His
    Mouse Bcl10-555M Recombinant Mouse Bcl10 Protein, His-tagged E.coli His
    Rat BCL10-956R Recombinant Rat BCL10 Protein Mammalian Cell His
    Rhesus Macaque BCL10-521R Recombinant Rhesus monkey BCL10 Protein, His-tagged Mammalian Cell His
    Chicken BCL10-4495C Recombinant Chicken BCL10 Mammalian Cell His

    BCL10 involved in several pathways and played different roles in them. We selected most pathways BCL10 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway IKBKB; MAP3K14; LTB; TNFRSF13C; Bcl2a1b; CD40; SYK; MAP3K7; GM13304; NFKBIA
    T cell receptor signaling pathway ZAP70; NFATC2; TEC; CBLC; NCK2; NFKBIB; BCL10; CD8A; CD3D; NFATC1
    B cell receptor signaling pathway PPP3R2; PPP3CA; PLCG2; PTPN18; LYN; CD81; MAPK1; LCP2A; KRAS; RAC3
    Tuberculosis BAX; NFYA; NOS2; PLK3; CASP8; RELA; Ifna15; TGFB1; HSPA9; C3

    BCL10 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL10 itself. We selected most functions BCL10 had, and list some proteins which have the same functions with BCL10. You can find most of the proteins on our site.

    Function Related Protein
    NF-kappaB binding BCL10; HSPA6; MTDH; FAF1; COMMD6; CDKN2A; AP1S2; RNF25; FOXP3; GSK3B
    enzyme binding Ar; HDAC6; GNB2L1; SELS; GOT2; NOXA1; FAM84B; CYP2A6; ECM1; MAPK14
    contributes_to kinase activator activity MALT1; BCL10
    kinase binding TRIP6; RPS3; SGOL1; PER3; PRKCD; PARK2; PPP1R9B; SP100; WWC2; HPCA
    protease binding BCL2; PYCARD; ANXA2; TIMP1; RYR1; FN1; SERPINE1; UBC; BRCA2; LCN2
    protein C-terminus binding VGLL3; PABPC1; OPRL1; XRCC4; PRDX3; MLLT4; KCNJ11; CALCOCO1; ARL6IP5; SDCBP2
    protein binding RNF14; ATP6V1D; TGM2; EMX2; PAEP; TRIM26; UBD; BCL11B; ZFYVE16; SIM1
    protein kinase B binding PDE3B; ANKRD2; PINK1; CDC37; TRAF6; CCDC88A; APPL1; BAD; RARA; BCL10
    protein kinase binding TTN; CD226; H2AFY; CAMK2N2; CCNT2B; DAXX; PIFO; CALM2; MAP2K7; GRIN2A
    protein self-association TRIM32; VAMP2; CNTN2; RSAD2; ZFP639; AGXT; SLC2A1; MALT1; AGTR1B; NKX3-1
    transcription coactivator activity CITED4; WNT3A; KAT2A; RAP2C; HINFP; MYCBP; FHL5; CITED2; BRDT; SUB1B
    transcription factor binding KLF5; LCOR; SIRT2; NKX2; PRICKLE1; MYOCD; DACT2; PARK7; FIGLA; SUFU
    ubiquitin binding C6orf106; FAN1; NUP62; VPS28; USP25; BCL10; FAM125A; VPS36; HSPB1; SQSTM1
    ubiquitin protein ligase binding TPI1; TRIM37; PIAS1; RAD18; CUL3; HIF1A; ARRB2; UBE2A; TXNIP; NEDD8

    BCL10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL10 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL10.

    MALT1; AKT1; CARD11

    Punwani, D; Wang, HP; et al. Combined Immunodeficiency Due to MALT1 Mutations, Treated by Hematopoietic Cell Transplantation. JOURNAL OF CLINICAL IMMUNOLOGY 35:135-146(2015).
    Zhao, XQ; Zhu, LL; et al. C-type Lectin Receptor Dectin-3 Mediates Trehalose 6,6 '-Dimycolate (TDM)-induced Mincle Expression through CARD9/Bcl10/MALT1-dependent Nuclear Factor (NF)-kappa B Activation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:30052-30062(2014).

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