bcl10
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  • Official Full Name
  • B-cell CLL/lymphoma 10
  • Background
  • This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
  • Synonyms
  • BCL10; B-cell CLL/lymphoma 10; CLAP; mE10; CIPER; c-E10; CARMEN
Cat.#:Bcl10-555MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Bcl10 Protein, His-tagged
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Cat.#:BCL10-1016HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human B-cell CLL/lymphoma 10
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Cat.#:BCL10-141HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BCL10 Protein, GST-tagged
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Cat.#:BCL10-16HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL10, His-tagged
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Cat.#:BCL10-8496HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human BCL10, His-tagged
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Cat.#:BCL10-956RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BCL10 Protein
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Cat.#:BCL10-521RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey BCL10 Protein, His-tagged
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Cat.#:BCL10-4495CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken BCL10
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Cat.#:BCL10-8490HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BCL10 293 Cell Lysate
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Involved Pathway

BCL10 involved in several pathways and played different roles in them. We selected most pathways BCL10 participated on our site, such as NF-kappa B signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL10 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
CXCL12; GADD45B; TNF; CCL4; GM1987; PTGS2; TNFSF14; TLR4; GM10591; IKBKG
T cell receptor signaling pathway
NFATC2; IFNG; NCK2; MAPK9; GRAPA; PIK3CG; IL5; CD3E; CD28; RAF1
B cell receptor signaling pathway
TTC6; ARPC4; ACTR3; NFKBIB; AKT2; MAPK3; CD79A; PIK3CB; BCL2L11; VAV3
Tuberculosis
CD209B; IFNA1; TNF; PPP3R2; HLA-DRB1; FADD; STAT1; MAPK12; AKT1; RFXAP

Protein Function

BCL10 has several biochemical functions, for example, NF-kappaB binding, enzyme binding, contributes_to kinase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL10 itself. We selected most functions BCL10 had, and list some proteins which have the same functions with BCL10. You can find most of the proteins on our site.
Function
Related Protein
Function NF-kappaB binding
Related Protein HDAC1; MTDH; SNAI1A; ANXA4; FOXP3; NPM1; COMMD6; HDAC2; ANKRD42; PSMA6
Function enzyme binding
Related Protein RCOR1; TULP3; HNRNPUL1; UBE2L3; HDAC10; HIST1H2AK; C2orf56; SIRT1; MAPT; MLEC
Function contributes_to kinase activator activity
Related Protein BCL10; MALT1
Function kinase binding
Related Protein JAKMIP1; WWC3; PARK7; SP100; DLG3; PTPN22; PFKM; TRIP6; DUSP12; CDC37
Function protease binding
Related Protein CD70; ANXA2; FLOT1; TRIP4; ITGB1; BCL10; DPP4; XBP1; FN1; INS1
Function protein C-terminus binding
Related Protein CD2AP; TAF13; TAE1; NIPBL; MYO1C; SDCBP; DGKZ; CAV3; ERCC6; BLOC1S2A
Function protein binding
Related Protein EHD1; TEN1; GNG10; Cd24a; RYR2; DST; KRTAP5-6; ARNT; GPR128; RNF20
Function protein kinase B binding
Related Protein ANKRD2; TRAF6; PDE3B; CCDC88A; APPL1; BAD; BCL10; PINK1; CDC37; RARA
Function protein kinase binding
Related Protein ATP1A1; FBXO7; FBXW5; PIFO; AKAP5; LIPE; CRY1; GSK3B; CAMK2N2; CDK5RAP2
Function protein self-association
Related Protein CCL5; CBR2; NKX3; TTN; SYP; SLC9A3R1; SVIP; ZKSCAN17; TRP53; TMEM190
Function transcription coactivator activity
Related Protein NFE2L3; YAF2; ACTL6A; PSMC3; SUPT7L; PCBD1; JUP; KAT2B; NR1I2; TDRD3
Function transcription factor binding
Related Protein MDFI; PAX6; DIP2B; CTBP1; DDX3X; TRAPPC2; NAB2; SMAD3; POU1F1; SUFU
Function ubiquitin binding
Related Protein UBE2NB; NSFL1C; KCNS1; CRY2; NUP62; SPRTN; UBXN11; OTUB2; NBR1; PER2
Function ubiquitin protein ligase binding
Related Protein GPR19; SLC25A5; TRAF6; SCN5A; RPA3; PER3; RNF20; YOD1; RRAGA; BAG4

Interacting Protein

BCL10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL10 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL10.
MALT1; AKT1; CARD11

BCL10 Related Articles

Punwani, D; Wang, HP; et al. Combined Immunodeficiency Due to MALT1 Mutations, Treated by Hematopoietic Cell Transplantation. JOURNAL OF CLINICAL IMMUNOLOGY 35:135-146(2015).
Zhao, XQ; Zhu, LL; et al. C-type Lectin Receptor Dectin-3 Mediates Trehalose 6,6 '-Dimycolate (TDM)-induced Mincle Expression through CARD9/Bcl10/MALT1-dependent Nuclear Factor (NF)-kappa B Activation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:30052-30062(2014).

BCL10 Related Gene Family

BCL2 Gene Family