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BCL2L1

  • Official Full Name

    BCL2-like 1

  • Overview

    The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008]
  • Synonyms

    BCL2L1; BCL2-like 1; BCLX; BCL2L; BCLXL; BCLXS; Bcl-X; bcl-xL; bcl-xS; PPP1R52; BCL-XL/S; bcl-2-like protein 1; apoptosis regulator Bcl-X; protein phosphatase 1, regulatory subunit 52;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Sus scrofa (Pig)
  • Zebrafish
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • SUMO
  • MYC
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BCL2L1-147H Recombinant Human BCL2L1 Protein, GST-tagged Wheat Germ GST
Human BCL2L1-1349H Recombinant Human BCL2L1, GST-tagged E.coli GST
Human BCL2L1-457H Recombinant Human BCL2L1 Mammalian Cell His
Human BCL2L1-348H Recombinant Human BCL2L1 protein E.coli N/A 211
Human BCL2L1-1851H Recombinant Human BCL2-like 1, His-tagged E.coli His
Human BCL2L1-6872H Recombinant Human BCL2L1, His tagged E.coli His
Human BCL2L1-511H Recombinant Human BCL2L1 protein, His-tagged E.coli His Met 1 - Arg 212
Human BCL2L1-10191H Recombinant Human BCL2L1, His-tagged E.coli His 1-233a.a.
Human BCL2L1-470H Recombinant Human BCL2-Like 1 E.coli N/A
Human BCL2L1-168H Recombinant Human BCL2L1 Protein E.coli N/A
Human BCL2L1-8488HCL Recombinant Human BCL2L1 293 Cell Lysate HEK293 N/A
Human BCL2L1-8489HCL Recombinant Human BCL2L1 293 Cell Lysate HEK293 N/A
Human BCL2L1-323H Recombinant Human BCL2L1 protein, GST-tagged E.coli GST 212
Human BCL2L1-439H-B Recombinant Human BCL2L1 Protein Pre-coupled Magnetic Beads HEK293
Human BCL2L1-2581H Recombinant Human BCL2L1 protein, His-SUMO-tagged E.coli His-SUMO 1-209aa
Human BCL2L1-3321H Recombinant Human BCL2L1 Protein E. coli N/A
Human BCL2L1-287HFL Active Recombinant Full Length Human BCL2L1 Protein, C-Flag-tagged Mammalian cells Flag
Human BCL2L1-139H Recombinant Human BCL2L1 protein, GST-tagged E. coli GST 1-233 aa
Human BCL2L1-1592HF Recombinant Full Length Human BCL2L1 Protein, GST-tagged In Vitro Cell Free System GST 233 amino acids
Human BCL2L1-439H Recombinant Human BCL2L1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BCL2L1-0383H Recombinant Human BCL2L1 Protein (Met1-Lys233), N-His-tagged E.coli N-His Met1-Lys233
Mouse Bcl2l1-6871M Active Recombinant Mouse Bcl2l1 protein(Met1-Arg212), His-tagged E. coli C-His Met1-Arg212
Mouse Bcl2l1-74M Recombinant Mouse Bcl2l1 protein, His-tagged Insect Cell His
Mouse Bcl2l1-698M Recombinant Mouse Bcl2l1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Bcl2l1-544M Recombinant Mouse Bcl2l1 protein E.coli N/A 211
Rat BCL2L1-958R Recombinant Rat BCL2L1 Protein Mammalian Cell His
Rat Bcl2l1-1242R Recombinant Rat Bcl2l1 protein, His-tagged E.coli His Ser2~Arg212 (Accession # P53563)
Rat BCL2L1-616R Recombinant Rat BCL2L1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat BCL2L1-616R-B Recombinant Rat BCL2L1 Protein Pre-coupled Magnetic Beads HEK293
Mus musculus (Mouse) RFL13751MF Recombinant Full Length Mouse Bcl-2-Like Protein 1(Bcl2L1) Protein, His-Tagged E.coli expression system His Full Length (1-233)
Rattus norvegicus (Rat) RFL18302RF Recombinant Full Length Rat Bcl-2-Like Protein 1(Bcl2L1) Protein, His-Tagged E.coli expression system His Full Length (1-233)
Rhesus Macaque BCL2L1-523R Recombinant Rhesus monkey BCL2L1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque BCL2L1-351R Recombinant Rhesus Macaque BCL2L1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque BCL2L1-351R-B Recombinant Rhesus Macaque BCL2L1 Protein Pre-coupled Magnetic Beads HEK293
Sus scrofa (Pig) RFL8692SF Recombinant Full Length Pig Bcl-2-Like Protein 1(Bcl2L1) Protein, His-Tagged E.coli expression system His Full Length (1-233)
Zebrafish BCL2L1-9318Z Recombinant Zebrafish BCL2L1 Mammalian Cell His
Chicken BCL2L1-2207C Recombinant Chicken BCL2L1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BCL2L1 Related Articles
  • BCL2L1 Related Gene Family
  • BCL2L1 Related Research Area
  • BCL2L1 Related Signal Pathway

BCL2L1 involved in several pathways and played different roles in them. We selected most pathways BCL2L1 participated on our site, such as Ras signaling pathway, NF-kappa B signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL2L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayPLA2G2F;RAF1;PIK3R5;GNG7;GNGT1;FGF6;MAPK10;PDGFD;PDGFA
NF-kappa B signaling pathwayBCL10;CCL21;DDX58;XIAP;CCL4L1;TRIM25;PLCG2;LY96;MAP3K14
PIK-Akt signaling pathwayGNG11;CCNE1;NFKB1;Reln;GNB1;PIK3R5;YWHAG;FOXO3;HGF
ApoptosisBMX;CAPN2A;OCLN;BOK;RELA;DIABLO;IL1RAP;CAPN2L;PIK3CG
Jak-STAT signaling pathwaySTAT3;IFNAR1;CSF3R;IL15RA;EPO;PIK3CG;PIAS4B;IL15;IL12B
Amyotrophic lateral sclerosis (ALS)DAXX;SLC1A2;TNFRSF1B;NEFM;CAT;PPP3CA;PPP3CB;DERL1;GPX1
ToxoplasmosisPDPK1;IRAK4;PIK3R3;PIK3CB;BIRC8;TYK2;IRGM1;PPIF;HLA-DRB4
HTLV-I infectionH2-AB1;POLE2;EGR1;TRP53;SMAD4;SLC2A1;IL1R2;NRP1;SLC25A5
Pathways in cancerFZD9;PRKCA;FZD5;TRP53;TGFBR2;MITF;APPL1;FASLG;BCL2L1
Transcriptional misregulation in cancerJMJD1C;DOT1L;CD14;CLSTN2;ETV4;TFE3;REL;TLX1;GOLPH3
Pancreatic cancerRELA;CASP9;RB1;NFKB1;IKBKB;MAPK10;PLD1;TGFBR1;RAC1
Chronic myeloid leukemiaSHC3;MAPK3;MECOM;TRP53;CDK6;KRAS;CBLB;CTBP1;PTPN11
Small cell lung cancerLAMC2;TRP53;NOS2;PIK3R2;PIK3R5;ITGA2;LAMB3;PIK3CB;NFKBIA

BCL2L1 has several biochemical functions, for example, BH3 domain binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL2L1 itself. We selected most functions BCL2L1 had, and list some proteins which have the same functions with BCL2L1. You can find most of the proteins on our site.

Function Related Protein
BH3 domain bindingBCL2;BCL2L1;BAX;MCL1
identical protein bindingPCNA;DIAP1;TNK2;SCAND1;SERPINA1D;CALHM1;TYSND1;DLC;B2M
protein bindingE2F8;GIT2;FAM126B;DEAF1;USF2;PACSIN1;HDAC7;FCN2;MEAF6
protein heterodimerization activityRALGAPA1;ADORA2A;H2AFX;UNC13A;SMAD3;BAX;KCNK9;POU5F3;UGT1A7
protein homodimerization activityXPNPEP1;MYOM1;SRM;DMRT2;HMGCS1;ACAT1;MCL1;CDA;ALX1
protein kinase bindingIL12RB2;GYS1;PAK2;SPDYE2;MAP2K3;LIMS1;CCND2;NEFH;CHRNA7

BCL2L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL2L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL2L1.

BAD; BAX; NLRP1

Garimella, SV; Gehlhaus, K; et al. Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening. BREAST CANCER RESEARCH 16:-(2014).
Lee, BS; Cha, HY; et al. AY4, an agonistic anti-death receptor 4 MAB, induces apoptotic cell death in anaplastic thyroid cancer cells via downregulation of Bcl-xL with reactive oxygen species generation. ENDOCRINE-RELATED CANCER 20:283-291(2013).
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