bcl2l1
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  • Official Full Name
  • BCL2-like 1
  • Background
  • The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008]
  • Synonyms
  • BCL2L1; BCL2-like 1; BCLX; BCL2L; BCLXL; BCLXS; Bcl-X; bcl-xL; bcl-xS; PPP1R52; BCL-XL/S; bcl-2-like protein 1; apoptosis regulator Bcl-X; protein phosphatase 1, regulatory subunit 52;
Cat.#:BCL2L1-3321HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2L1 Protein
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Cat.#:BCL2L1-323HTag:GST
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human BCL2L1 Protein (Met 1 - Arg 212), GST-tagged
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Cat.#:BCL2L1-10191HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2L1, His-tagged
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Cat.#:BCL2L1-1349HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2L1, GST-tagged
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Cat.#:BCL2L1-147HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BCL2L1 Protein, GST-tagged
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Cat.#:BCL2L1-168HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2L1 Protein
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Cat.#:BCL2L1-348HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2L1 protein
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Cat.#:BCL2L1-457HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human BCL2L1
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Cat.#:BCL2L1-511HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2L1, His-tagged
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Cat.#:BCL2L1-6872HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2L1, His tagged
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Cat.#:Bcl2l1-6871MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Bcl2l1, His tagged
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Cat.#:Bcl2l1-74MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse Bcl2l1 protein, His-tagged
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Cat.#:Bcl2l1-1242RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Bcl2l1 protein, His-tagged
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Cat.#:BCL2L1-958RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BCL2L1 Protein
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Cat.#:BCL2L1-523RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey BCL2L1 Protein, His-tagged
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Cat.#:BCL2L1-2207CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken BCL2L1
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Cat.#:BCL2L1-9318ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish BCL2L1
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Cat.#:BCL2L1-1851HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2-like 1, His-tagged
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Cat.#:BCL2L1-470HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2-Like 1
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Cat.#:BCL2L1-8488HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BCL2L1 293 Cell Lysate
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Cat.#:BCL2L1-8489HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BCL2L1 293 Cell Lysate
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Involved Pathway

BCL2L1 involved in several pathways and played different roles in them. We selected most pathways BCL2L1 participated on our site, such as Ras signaling pathway, NF-kappa B signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL2L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
ETS1; KRAS; SOS1; GAB2; FGFR3; NFKB1; PGF; HGF; ANGPT4; GNB1
NF-kappa B signaling pathway
LAT; PRKCB; PLAU; NFKBIA; CXCL2; CD14; ICAM1; MAP3K7; IRAK1; LCK
PIK-Akt signaling pathway
FN1; PHLPP1; YWHAH; IFNA5; TSC2; G6PC; RELA; IL2RA; FGF10; RHEB
Apoptosis
HIST1H1D; HMGB2; HIST1H1E; CDKN2A; CASP6; NFKBIAA; HDR; CAPN2; PLEC; PRKACG
Jak-STAT signaling pathway
IL10RA; LEPA; IFNAR1; PIK3R5; PTPN2A; GRB2; M17; IL13; AOX3L1; PIK3CG
Amyotrophic lateral sclerosis (ALS)
CASP12; Casp3; CASP9; MAPK13; TNF; NEFL; NEFH; GRIA1; DERL1; PRPH
Toxoplasmosis
CYCS; TAB2; ALOX5; MAPK11; H2-AA; IFNGR1; TLR2; IRAK1; IKBKB; IL12B
HTLV-I infection
TBP; KAT2A; ATF4; CALR; RELB; KAT2B; SLC25A6; HLA-DRA; AKT2; NRP1
Pathways in cancer
HSP90AB1; CBLB; TRAF6; PIK3R2; WNT3A; TFG; HGF; FGF10; GLI2; TRAF5
Transcriptional misregulation in cancer
NUPR1; PER2; LYL1; FEV; H3F3A; ETV7; PAX7; LDB1; MAX; FOXO1
Pancreatic cancer
TGFBR1; VEGFA; PIK3CB; MAPK3; STAT3; STAT1; KRAS; CASP9; MAPK8; BCL2L1
Chronic myeloid leukemia
PIK3R2; PIK3CB; MAP2K1; RUNX1; ABL1; SOS1; NFKB1; CDK6; MAPK3; SMAD3
Small cell lung cancer
MAX; LAMA5; ITGA3; FN1; BIRC3; PIK3CB; TRAF5; TRAF4; LAMA3; LAMB4

Protein Function

BCL2L1 has several biochemical functions, for example, BH3 domain binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL2L1 itself. We selected most functions BCL2L1 had, and list some proteins which have the same functions with BCL2L1. You can find most of the proteins on our site.
Function
Related Protein
Function BH3 domain binding
Related Protein BCL2; BCL2L1; MCL1; BAX
Function identical protein binding
Related Protein GOT2B; B2M; STAT6; IL12B; ATG16L1; ALDOA; ATF3; DRD4; SERPINB1A; PRDX3
Function protein binding
Related Protein ADA; RNF182; CCNG1; XAGE2; CLOCKB; C1orf38; HPRT1; TUBA1A; RTN4; LCOR
Function protein heterodimerization activity
Related Protein RELA; ATF2; CHRAC1; HNF1B; ATP4A; NPAS4; AHR; ATF4; BTBD11; EXT1
Function protein homodimerization activity
Related Protein NFS1; ATIC; Il6ra; PEX11B; TENM3; CEP57; UBE4A; TGFB1; PTPRO; SLC16A1
Function protein kinase binding
Related Protein CEP152; CHEK2; RCC2; TOM1L1; VRK1; ATP1A1; RPS6; MAP2K7; IRS2; DNM1

Interacting Protein

BCL2L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL2L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL2L1.
BAD; BAX; NLRP1

BCL2L1 Related Articles

Garimella, SV; Gehlhaus, K; et al. Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening. BREAST CANCER RESEARCH 16:-(2014).
Lee, BS; Cha, HY; et al. AY4, an agonistic anti-death receptor 4 MAB, induces apoptotic cell death in anaplastic thyroid cancer cells via downregulation of Bcl-xL with reactive oxygen species generation. ENDOCRINE-RELATED CANCER 20:283-291(2013).

BCL2L1 Related Gene Family

BCL2 Gene Family