bcl2l1
Share
  • Official Full Name
  • BCL2-like 1
  • Background
  • The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008]
  • Synonyms
  • BCL2L1; BCL2-like 1; BCLX; BCL2L; BCLXL; BCLXS; Bcl-X; bcl-xL; bcl-xS; PPP1R52; BCL-XL/S; bcl-2-like protein 1; apoptosis regulator Bcl-X; protein phosphatase 1, regulatory subunit 52;
Cat.#:BCL2L1-3321HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2L1 Protein
+Inquiry
Cat.#:BCL2L1-323HTag:GST
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human BCL2L1 Protein (Met 1 - Arg 212), GST-tagged
+Inquiry
Cat.#:BCL2L1-10191HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2L1, His-tagged
+Inquiry
Cat.#:BCL2L1-1349HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2L1, GST-tagged
+Inquiry
Cat.#:BCL2L1-147HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BCL2L1 Protein, GST-tagged
+Inquiry
Cat.#:BCL2L1-168HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2L1 Protein
+Inquiry
Cat.#:BCL2L1-348HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2L1 protein
+Inquiry
Cat.#:BCL2L1-457HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human BCL2L1
+Inquiry
Cat.#:BCL2L1-511HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2L1, His-tagged
+Inquiry
Cat.#:BCL2L1-6872HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2L1, His tagged
+Inquiry
Cat.#:Bcl2l1-6871MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Bcl2l1, His tagged
+Inquiry
Cat.#:Bcl2l1-74MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse Bcl2l1 protein, His-tagged
+Inquiry
Cat.#:Bcl2l1-1242RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Bcl2l1 protein, His-tagged
+Inquiry
Cat.#:BCL2L1-958RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BCL2L1 Protein
+Inquiry
Cat.#:BCL2L1-523RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey BCL2L1 Protein, His-tagged
+Inquiry
Cat.#:BCL2L1-2207CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken BCL2L1
+Inquiry
Cat.#:BCL2L1-9318ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish BCL2L1
+Inquiry
Cat.#:BCL2L1-1851HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2-like 1, His-tagged
+Inquiry
Cat.#:BCL2L1-470HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2-Like 1
+Inquiry
Cat.#:BCL2L1-8488HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BCL2L1 293 Cell Lysate
+Inquiry
Cat.#:BCL2L1-8489HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BCL2L1 293 Cell Lysate
+Inquiry

Involved Pathway

BCL2L1 involved in several pathways and played different roles in them. We selected most pathways BCL2L1 participated on our site, such as Ras signaling pathway, NF-kappa B signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL2L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
PRKACB; INS1; FGF10; CDC42; RAB5C; RAC1; PLA2G2E; PLA2G4D; INSR; GNG8
NF-kappa B signaling pathway
VCAM1; CCL13; LTA; LY96; BCL2; BCL10; TRAF6; IKBKG; PIAS4; MAP3K7IP3
PIK-Akt signaling pathway
PPP2R2D; FOXO3; ITGB4; FGFR3; TSC1; FGF7; PRKCA; BAD; KIT; ITGA6
Apoptosis
GAS2; CAPN2L; BIDA; BIRC8; IRF1B; PRKAR2AA; BIRC2; DIABLOB; IRAK1; HIST1H1A
Jak-STAT signaling pathway
IL27RA; NT5C3; IFNGR2; IL2RB; PTPN11B; STAT2; STAT1; IL9; IL6ST; SOCS5
Amyotrophic lateral sclerosis (ALS)
GPX1; PPP3R1; DAXX; NEFL; GRIA1; PPP3R2; MAPK14; GRIN2A; TRP53; PRPH
Toxoplasmosis
Toxoplasma Gondii Dense Granule Protein 7; STAT1; HLA-DRB4; PIK3CG; IRAK4; HSPA1L; PIK3CD; MAPK3; MAP2K6; BIRC3
HTLV-I infection
NFKBIA; FOS; PTTG2; CDC16; HLA-DQB1; POLD2; KAT2B; ANAPC11; SMAD4; ITGAL
Pathways in cancer
BIRC5; FH; TGFB3; STAT5A; PLEKHG5; MAP2K2; FOXO1; GNB4; LPAR5; WNT9A
Transcriptional misregulation in cancer
HIST1H3F; MEF2C; TGFBR2; FOXO1; PAX7; FCGR1; BCL6; SIX4; GZMB; WHSC1
Pancreatic cancer
MAPK9; BCL2L1; MAP2K1; IKBKB; TGFB1; TGFBR1; TGFB3; BAD; TGFA; RELA
Chronic myeloid leukemia
TP53; HDAC1; PIK3CB; BRAF; CCND1; CTBP1; MECOM; CRK; SMAD4; KRAS
Small cell lung cancer
PIK3CB; FN1; TRAF2; CCNE2; BIRC2; TRAF1; PIAS2; TRAF4; COL4A1; CKS2

Protein Function

BCL2L1 has several biochemical functions, for example, BH3 domain binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL2L1 itself. We selected most functions BCL2L1 had, and list some proteins which have the same functions with BCL2L1. You can find most of the proteins on our site.
Function
Related Protein
Function BH3 domain binding
Related Protein MCL1; BAX; BCL2L1; BCL2
Function identical protein binding
Related Protein RGMB; PRKD1; DVL2; MNS1; STK4; SMN1; APOH; IL12B; PYCARD; SCHIP1
Function protein binding
Related Protein AGTRAP; FANCD2; C4orf19; PSMA3; TSNAX; DGCR6L; PLP2; C8orf48; CD200R4; KIF18A
Function protein heterodimerization activity
Related Protein H3F3B; KCNH5; ATF4; GAD2; HIST1H2BH; SYT10; SOX15; H2AFB3; SIM1; DMRT3
Function protein homodimerization activity
Related Protein CISD2; CEBPA; HM13; IKZF4; IL6ST; KLHL7; SLK; Bcl2a1b; ID1; MGST1
Function protein kinase binding
Related Protein NEFH; MAP3K13; CRY1; CCNL1A; CDC25B; NCS1; RAB8A; HSPB1; DNAJC3; MAP3K12

Interacting Protein

BCL2L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL2L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL2L1.
BAD; BAX; NLRP1

BCL2L1 Related Articles

Garimella, SV; Gehlhaus, K; et al. Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening. BREAST CANCER RESEARCH 16:-(2014).
Lee, BS; Cha, HY; et al. AY4, an agonistic anti-death receptor 4 MAB, induces apoptotic cell death in anaplastic thyroid cancer cells via downregulation of Bcl-xL with reactive oxygen species generation. ENDOCRINE-RELATED CANCER 20:283-291(2013).

BCL2L1 Related Gene Family

BCL2 Gene Family