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Recombinant Human BCL2L1 Protein

Cat.No. : BCL2L1-3321H
Product Overview : Recombinant Human BCL2L1 Protein is produced by E. coli expression system.
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  • Gene Information
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Description : Bcl-X, also named as BCL2L1 or BCL2L, belongs to the Bcl-2 family and it is encoded by the BCL2L1 gene in human. Alternative splicing of Bcl-X results in at least two isoforms, isoform Bcl-X(L) (also named as Bcl-xL) and isoform Bcl-x(S) (also named as Bcl-xS). Bcl-xL is found in tissues containing long-lived postmitotic cells, such as adult brain, while Bcl-xS is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. Bcl-X forms homodimer or heterodimer with other Bcl-2 proteins, like BAK, BAX or Bcl-2, to act as anti- or pro- apoptotic regulators. Bcl-xL appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane, and it also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. In contrast, Bcl-xS is a pro-apoptotic protein that promotes apoptosis.
Source : E. coli
Species : Human
Form : Lyophilized from a 0.2 um filtered concentrated solution in 20 mM Tris-HCl, pH 8.0, 5 % Trehalose.
Molecular Mass : 23.7 kDa
AA Sequence : SQSNRELVVD FLSYKLSQKG YSWSQFSDVE ENRTEAPEGT ESEMETPSAI NGNPSWHLAD SPAVNGATGH SSSLDAREVI PMAAVKQALR EAGDEFELRY RRAFSDLTSQ LHITPGTAYQ SFEQVVNELF RDGVNWGRIV AFFSFGGALC VESVDKEMQV LVSRIAAWMA TYLNDHLEPW IQENGGWDTF VELYGNNAAA ESRKGQERFN R
Endotoxin : < 0.1 EU/ug of endotoxin as determined by LAL method.
Purity : > 97 % pure by SDS-PAGE and HPLC
Notes : This lyophilized preparation is stable at 2-8 degrees C, but should be kept at -20 degrees C for long term storage, preferably desiccated. Upon reconstitution, the preparation is most stable at -20 to -80 degrees C, and can be stored for one week at 2-8 degrees C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degrees C to -80 degrees C. Avoid repeated freeze/thaw cycles. This product is for research use only and is not approved for use in humans or in clinical diagnosis.
Storage : Store at -20 centigrade. Avoid freeze-thaw cycles.
Concentration : LYOPH
Preservative : 5% Trehalose
Reconstitution : Reconstitute with sterilized distilled water or 0.1% BSA aqueous buffer to a final concentration of 0.1 - 1.0 mg/ml.
Gene Name : BCL2L1 BCL2-like 1 [ Homo sapiens ]
Official Symbol : BCL2L1
Synonyms : BCL2L1; BCL2-like 1; Bcl X; bcl xL; bcl xS; BCL2L; BCLX; PPP1R52; BCLXL; BCLXS; Bcl-X; bcl-xL; bcl-xS; BCL-XL/S; DKFZp781P2092;
Gene ID : 598
mRNA Refseq : NM_001191
Protein Refseq : NP_001182
MIM : 600039
UniProt ID : Q07817

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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