bcl9
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  • Official Full Name
  • B-cell CLL/lymphoma 9
  • Background
  • BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008]
  • Synonyms
  • BCL9; B-cell CLL/lymphoma 9; LGS; B-cell CLL/lymphoma 9 protein; bcl-9; protein legless homolog; B-cell lymphoma 9 protein;
Cat.#:BCL9-10190HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL9, GST-tagged
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Cat.#:BCL9-1243HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL9 protein, His & T7-tagged
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Cat.#:BCL9-168HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BCL9 Protein, GST-tagged
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Cat.#:Bcl9-1244MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Bcl9 protein, His & T7-tagged
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Cat.#:BCL9-2356MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BCL9 Protein
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Cat.#:BCL9-527RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey BCL9 Protein, His-tagged
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Cat.#:BCL9-1443ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish BCL9
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Involved Pathway

BCL9 involved in several pathways and played different roles in them. We selected most pathways BCL9 participated on our site, such as Deactivation of the beta-catenin transactivating complex, Formation of the beta-catenin:TCF transactivating complex, Regulation of Wnt-mediated beta catenin signaling and target gene transcription, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL9 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Deactivation of the beta-catenin transactivating complex
PYGO2; SOX6; CBY1; SOX4A; SOX9B; RBBP5; SOX13; SOX7; SRY; PYGO1
Formation of the beta-catenin:TCF transactivating complex
PYGO2; BCL9L; TLE4; ASH2L; TLE3B; TLE3; CDC73; H3F3B.1; BCL9; TLE2
Regulation of Wnt-mediated beta catenin signaling and target gene transcription
AES; SALL4; TLE1; CBY1; TCF4; TLE4; KCNIP4; HBP1; TLE2; BCL9
Signal Transduction
RTN4; CSN2; TNKS; DRAP1; SAGB; GPR68; RBP1; ARHGEF3; RTKN; NOXO1A
Signaling by Wnt
CCDC88C; BCL9; USP34; RSPO4; LEO1; SOX9A; KLHL12; RNF146; ASH2L; KREMEN2
TCF dependent signaling in response to WNT
SOX4A; SOX32; HECW1B; SOX6; SOX7; DACT1; KREMEN1; RSPO1; RSPO2; C
Wnt Signaling Pathway NetPath
ANKRD6; MARK2; CSNK2A1P; HIPK2; MAP1B; PAX2; MTAP1B; TCF4; TAX1BP3; CRYBB2

Protein Function

BCL9 has several biochemical functions, for example, beta-catenin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL9 itself. We selected most functions BCL9 had, and list some proteins which have the same functions with BCL9. You can find most of the proteins on our site.
Function
Related Protein
Function beta-catenin binding
Related Protein HDAC6; DACT2; CTNNBIP1; AXIN1; BCL9; PXN; GSK3B; SOX17; C; PROP1
Function protein binding
Related Protein CDH2; FHIT; ZNF155; EDA; SVIL; SLC38A2; FAM50B; TOB1A; TRIM24; DACH1

Interacting Protein

BCL9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL9 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL9.
PYGO1; PYGO2; CDC73; arm; CTNNB1; h3_peptide_fragment; TCF4; Ctnnb1

BCL9 Related Gene Family

BCL2 Gene Family