This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene.
BEX2; brain expressed X-linked 2; protein BEX2; DJ79P11.1; BEX 1; BEX 2; BEX1; Brain expressed X linked 2; Brain expressed X linked protein 2 homolog; brain expressed X-linked 1; HBEX2; HGR74-h; uncharacterized hypothalamus protein HBEX2; X-linked protein; OTTHUMP00000023734; OTTHUMP00000023735; OTTHUMP00000023736; brain-expressed X-linked protein 2
BEX2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BEX2 itself. We selected most functions BEX2 had, and list some proteins which have the same functions with BEX2. You can find most of the proteins on our site.
Function protein binding
Related Protein TWIST1; LRRC4B; NEGR1; IP6K2; EFEMP2; KLRB1F; ATF2; EP400; MKI67; TRIM67
BEX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BEX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BEX2.