BLM
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Official Full Name
Bloom syndrome, RecQ helicase-like
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Overview
The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3-5 helicase activity.The normal protein may act to suppress inappropriate recombination. -
Synonyms
BLM; Bloom syndrome, RecQ helicase-like; Bloom syndrome; Bloom syndrome protein; BS; RECQ2; RECQL3; recQ protein-like 3; DNA helicase, RecQ-like type 2; RECQL2; MGC126616; MGC131618; MGC131620;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|Myc
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | BLM-241H | Recombinant Human BLM Protein, GST-tagged | Wheat Germ | GST | ||
Human | BLM-34H | Recombinant Human BLM Protein | E.coli | |||
Mouse | BLM-2415M | Recombinant Mouse BLM Protein | Mammalian Cell | His | ||
Mouse | BLM-2206M | Recombinant Mouse BLM Protein (684-859 aa), His-Myc-tagged | E.coli | His/Myc | 684-859 aa | |
Mouse | BLM-1040M-B | Recombinant Mouse BLM Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | BLM-1040M | Recombinant Mouse BLM Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Chicken | BLM-1738C | Recombinant Chicken BLM | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- BLM Related Articles
BLM involved in several pathways and played different roles in them. We selected most pathways BLM participated on our site, such as Homologous recombination, Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BLM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Homologous recombination | BLM;RAD54L;SSBP1;SYCP3;RPA2;RAD51L3;RAD51L1;POLD1;POLD4 |
Fanconi anemia pathway | RAD51C;RPA1;CDK5R2;MLH1;FANCI;POLI;DCLRE1A;ERCC1;FAN1 |
BLM has several biochemical functions, for example, ATP binding, ATP-dependent 3-5 DNA helicase activity, ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BLM itself. We selected most functions BLM had, and list some proteins which have the same functions with BLM. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | MAPK3;ASS1;NUAK2;YARS2;EHD4;ATP6V1BA;PTK6;GSK3AB;RPS6KA3 |
ATP-dependent 3-5 DNA helicase activity | ASCC3;RECQL4;WRN;BLM |
ATP-dependent DNA helicase activity | FBXO18;XRCC5;G3BP1;DDX11;CHD1;BRIP1;CHD4;CHST13;GTF2H4 |
ATP-dependent helicase activity | RECQL5;CHD4A;DHX36;ERCC6L2;TTF2;BLM;CHD6;SNRNP200;RTEL1 |
ATPase activity | TOR1B;ATF7IP;HSPA1A;ABCE1;HSP90AA1;ABCC1;ABCG3;DNAH6;PICK1 |
DNA binding | EGR3;KLF14;SIX2B;HLFA;ENG2B;ADAR;HOXB8B;FOXO6;IRX2A |
G-quadruplex DNA binding | WRN;LONP1;DHX36;BLM |
annealing helicase activity | RECQL4;RAD54L;ANXA1;ZRANB3;BLM;SMARCAL1;RECQL |
bubble DNA binding | BLM;HMGB1;ERCC5;NEIL3;WRN;RECQL4 |
catalytic activity | ECI2;ISOC2;HOGA1;AGLA;LYZ2;TM9SF1;EML5;ALDOAA;CKBB |
four-way junction helicase activity | BLM;WRN |
helicase activity | FANCM;SHPRH;EIF4A1;HELQ;UPF1;DHX32A;CHD9;DDX58;PIF1 |
hydrolase activity | HDAC9B;ABHD8;PPM1AA;ST14A;PRSS28;ANG4;C1rb;KLK1B11;ATP1A3A |
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | RTEL1;CHD4A;BLM |
nucleic acid binding | SNRNP27;Akap17b;HNRNPA0L;GPATCH1;EIF2S1A;FAM90A1;EXOG;ZBTB46;ZFP536 |
nucleotide binding | APOA1BP;GSPT1L;EPHA4A;HNRNPH1L;PFKMB;RHOU;ATP1A3A;SETX;CAMK2G1 |
p53 binding | TRP63;STK11;ZFP346;MSX1;KDM1A;TP53;TRP53;TRIAP1;BRD4 |
protein binding | RPA3;C1QTNF9B-AS1;MVP;NUP107;FOXP1;RNF216;MBD4;GGA3;TXN2 |
single-stranded DNA binding | HNRNPK;CDAN1;RAD51AP1;MCM6;BRCA2;RBMS1;TTC6;TDP1;LRPPRC |
BLM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BLM here. Most of them are supplied by our site. Hope this information will be useful for your research of BLM.
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