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  • Official Full Name
  • brain and reproductive organ-expressed (TNFRSF1A modulator)
  • Background
  • BRCA1-A complex subunit BRE is a protein that in humans is encoded by the BRE gene.
  • Synonyms
  • BRE; brain and reproductive organ-expressed (TNFRSF1A modulator); BRCA1-A complex subunit BRE; BRCA1/BRCA2 containing complex; subunit 4; BRCC4; BRCC45; BRCA1/BRCA2-containing complex subunit 45; BRCA1/BRCA2-containing complex, subunit 4; brain and reprod
Cat.#:BRE-335HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BRE Protein, GST-tagged
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Cat.#:BRE-1013RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BRE Protein
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Cat.#:BRE-1836CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken BRE
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Cat.#:BRE-2520ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish BRE
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Cat.#:BRE-8409HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BRE 293 Cell Lysate
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Involved Pathway

BRE involved in several pathways and played different roles in them. We selected most pathways BRE participated on our site, such as Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell Cycle
SMAD3B; CHEK2; LIN52; CCNB3; DYRK1A; FZR1; MASTL; E2F4; NCAPD3; CENPL
Cell Cycle Checkpoints
CDK2; TP53BP1; UBE2V2; KAT5; MCM8; CDKN1B; BRE; YWHAQ; HUS1; CHEK1
DNA Double Strand Break Response
TP53BP1; EYA2; CHEK2; UIMC1; BABAM1; FAM175A; RNF168; KDM4B; KDM4A; EYA4
DNA Double-Strand Break Repair
RNF4; RAD51AP1; PPP4R2A; EYA3; CLSPN; EME2; KDM4A; SMARCA5; TP53BP1; UIMC1
DNA Repair
POLD3; ACTL6A; KDM4A; ELL; WRN; RBBP8; RHNO1; MAD2L2; ALKBH3; TDP2B
G2/M Checkpoints
RAD9A; FAM175A; RAD9B; THRSP; RAD1; BABAM1; HUS1; RAD17; RNF168; UIMC1
G2/M DNA damage checkpoint
BABAM1; THRSP; FAM175A; TP53BP1; UIMC1; BRE; BRCC3; BARD1; RNF168
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
TP53BP1; PPP4CB; PPP4R2B; THRSP; PPP4CA; TOPBP1; BABAM1; RAD9B; FAM175A; KIAA0146

Protein Function

BRE has several biochemical functions, for example, peroxisome targeting sequence binding, polyubiquitin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRE itself. We selected most functions BRE had, and list some proteins which have the same functions with BRE. You can find most of the proteins on our site.
Function
Related Protein
Function peroxisome targeting sequence binding
Related Protein BRE; PEX5; PEX5L
Function polyubiquitin binding
Related Protein RAD23B; UBQLN1; FAM175B; DNAJB2; VCP; RAD23A; TNIP2; TNIP3; HDAC6; THRSP
Function protein binding
Related Protein TRAF7; PRLHR; HFE2; PPP3CB; Clec4n; MC4R; MYC; C15orf23; PIK3IP1; GFER
Function tumor necrosis factor receptor binding
Related Protein TRADD; TRIM37; TNFSF11; LTB; TNFSF10L; TNFSF10L3; ERAP1; TNFSF12; TNFSF8; TRAF6

Interacting Protein

BRE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRE here. Most of them are supplied by our site. Hope this information will be useful for your research of BRE.
BABAM1; BRCC3; FAM175B; RPN2; SHMT2; PHB; LRPPRC; CUL1; FKBP8; ATG2A; DHRS7B; FAM175A; USP7; TTC28

BRE Related Articles

Karamitopoulou, E; Zlobec, I; et al. Proposal for a 10-high-power-fields scoring rnethod for the assessment of tumor budding in colorectal cancer. MODERN PATHOLOGY 26:295-301(2013).
Lang, LX; Li, WH; et al. New Methods for Labeling RGD Peptides with Bromine-76. THERANOSTICS 1:341-353(2011).