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C1QB

  • Official Full Name

    complement component 1, q subcomponent, B chain

  • Overview

    This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in;order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus;erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six;C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The;A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of;human complement subcomponent C1q.
  • Synonyms

    C1QB; complement component 1, q subcomponent, B chain; complement component 1, q subcomponent, beta polypeptide; complement C1q subcomponent subunit B; Complement component 1 q subcomponent B chain; Complement component 1 q subcomponent beta polypeptide; Complement component C1q B chain; Complement subcomponent C1q chain B; OTTHUMP00000002940; OTTHUMP00000002941; complement component C1q, B chain;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human C1QB-596H Recombinant Human C1QB, His tagged Insect Cell His
Human C1QB-651HCL Recombinant Human C1QB cell lysate Insect Cell N/A
Human C1QB-599H Recombinant human C1QB protein, His-tagged E.coli His
Human C1QB-464H Recombinant Human C1QB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human C1QB-4752H Recombinant Human C1QB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human C1QB-2136HFL Recombinant Full Length Human C1QB Protein, C-Flag-tagged Mammalian cells Flag
Human C1QB-464H-B Recombinant Human C1QB Protein Pre-coupled Magnetic Beads HEK293
Mouse C1QB-2561M Recombinant Mouse C1QB Protein Mammalian Cell His
Mouse C1QB-1132M Recombinant Mouse C1QB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse C1QB-1132M-B Recombinant Mouse C1QB Protein Pre-coupled Magnetic Beads HEK293
Mouse C1qb-730M Recombinant Mouse C1qb Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat C1QB-1042R Recombinant Rat C1QB Protein Mammalian Cell His
Rat C1QB-700R Recombinant Rat C1QB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat C1QB-700R-B Recombinant Rat C1QB Protein Pre-coupled Magnetic Beads HEK293
Zebrafish C1QB-926Z Recombinant Zebrafish C1QB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • C1QB Related Articles
  • C1QB Related Research Area

C1QB involved in several pathways and played different roles in them. We selected most pathways C1QB participated on our site, such as Complement and coagulation cascades, Prion diseases, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C1QB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesCFD;F5;C5AR1;Serpina1b;F12;C1S;SERPINF2;C4BP;PLAUR
Prion diseasesC7;IL1A;C1QB;NOTCH1;FYN;IL1B;SOD1;ELK1;HSPA5
PertussisGNAI3;MAPK9;FOS;CASP7;Casp3;MAPK8;Hc;MAPK11;IRF8
Chagas disease (American trypanosomiasis)PPP2R2A;PIK3CD;CCL5;ACE;IL12B;MAPK11;NOS2;TLR2;Fasl
Staphylococcus aureus infectionHLA-DPA1;C5;FCGR2A;C5AR1;C1QC;ITGB2L;C1RA;HLA-DRA;HLA-DMA
Systemic lupus erythematosusGM14477;SNRPD3;HIST1H2AP;HLA-DRB4;FCGR4;HIST1H2AM;C2;H2AFX;HIST1H2AJ

C1QB has several biochemical functions, for example, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C1QB itself. We selected most functions C1QB had, and list some proteins which have the same functions with C1QB. You can find most of the proteins on our site.

Function Related Protein
protein bindingGNB2L1;SRGAP1;DPYSL2;LCE3C;MPDU1;EDEM1;BFSP2;HOXA10;CANX
protein homodimerization activityCARS;EVLA;G6PD;TWIST1;TERF1;PON1;BOKB;MCL1A;NADK2

C1QB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C1QB here. Most of them are supplied by our site. Hope this information will be useful for your research of C1QB.

C1QA; RELA; q7chk1_yerpe; sbcD; treC; q81sh2_bacan; EDA2R

Yuan, HY; Chen, R; et al. Crystallization and preliminary crystallographic studies of the complement 1qA globular domain from zebrafish, Dare-C1qAgD. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 70:911-914(2014).
Nagano, F; Kaneko, T; et al. Gram-positive bacteria as an antigen topically applied into gingival sulcus of immunized rat accelerates periodontal destruction. JOURNAL OF PERIODONTAL RESEARCH 48:420-427(2013).
  • Q&As
  • Reviews

Q&As (7)

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What role does C1QB play in opsonization? 04/08/2022

C1QB, as part of C1q, plays a role in opsonization by marking pathogens and immune complexes for phagocytosis after binding and activating the complement system.

What is the primary function of the C1QB protein in the complement system? 10/26/2021

C1QB is one of the chains (together with C1QA and C1QC) that forms the C1q molecule, which is the first component of the classical pathway of the complement system, playing a crucial role in innate immunity.

Are there any therapeutic implications related to targeting C1QB in diseases? 08/13/2020

Given the role of C1QB in the complement system and its association with autoimmune diseases, targeting C1QB or its interactions might be a therapeutic strategy for conditions like SLE or other complement-mediated diseases.

What is the significance of C1QB in immune responses? 06/01/2020

C1QB, as a part of the C1q molecule, plays a significant role in recognizing and binding to immune complexes, apoptotic cells, and certain pathogens, thereby activating the classical complement pathway and facilitating their clearance.

How does C1QB interact with other components of the complement system? 11/08/2019

Once C1q (comprising C1QA, C1QB, and C1QC) binds to immune complexes, it triggers the binding and autoactivation of C1r and C1s serine proteases, forming the active C1 complex and initiating the classical complement cascade.

How does C1QB contribute to the formation of the C1 complex? 11/04/2019

C1q is a hexamer formed by the association of six C1qA, six C1qB, and six C1qC chains. C1QB contributes to this hexameric structure, which is essential for the recognition of immune complexes.

Are there any known genetic mutations in the C1QB gene associated with diseases? 05/05/2018

Mutations in the C1QB gene can lead to C1q deficiency, which is associated with an increased risk of systemic lupus erythematosus (SLE) and other autoimmune diseases.

Customer Reviews (3)

Write a review
Reviews
02/13/2022

    Product is worth the price.

    09/09/2019

      Outstanding performance in experiments.

      04/03/2019

        Excellent for biochemical assays.

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