c1qb
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  • Official Full Name
  • complement component 1, q subcomponent, B chain
  • Background
  • This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in;order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus;erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six;C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The;A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of;human complement subcomponent C1q.
  • Synonyms
  • C1QB; complement component 1, q subcomponent, B chain; complement component 1, q subcomponent, beta polypeptide; complement C1q subcomponent subunit B; Complement component 1 q subcomponent B chain; Complement component 1 q subcomponent beta polypeptide; Complement component C1q B chain; Complement subcomponent C1q chain B; OTTHUMP00000002940; OTTHUMP00000002941; complement component C1q, B chain
Cat.#:C1QB-596HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human C1QB, His tagged
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Cat.#:C1QB-2561MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse C1QB Protein
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Cat.#:C1QB-1042RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat C1QB Protein
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Cat.#:C1QB-926ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish C1QB
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Cat.#:C1QB-651HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human C1QB cell lysate
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Involved Pathway

C1QB involved in several pathways and played different roles in them. We selected most pathways C1QB participated on our site, such as Complement and coagulation cascades, Prion diseases, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C1QB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Complement and coagulation cascades
Serpina1c; C6; C3AR1; CD59A; SERPINA1A; F2R; MBL1; SERPINE1; KLKB1; CD46
Prion diseases
PRKACB; C1QC; PRKACA; NOTCH1; C8G; LAMC1; MAP2K1; C9; IL1B; MAPK3
Pertussis
MAPK9; C4BPA; CXCL6; LY96; TLR4; C3; Casp3; C4A; CALM2; IRF3
Chagas disease (American trypanosomiasis)
NFKB1; PPP2R2D; PPP2R1A; GNA15; MAPK10; MAPK3; TGFB3; PPP2CB; TLR6; CCL5
Staphylococcus aureus infection
FPR2; FCGR2A; C2; HLA-DQA2; C5AR1; HLA-DPB1; MASP1; HLA-DRB3; HLA-DQA1; C1S
Systemic lupus erythematosus
H2BFWT; HIST1H3D; HIST3H3; HIST1H2AL; SNRPB; HIST1H2AP; CD86; CD80; ACTN3; ACTN2

Protein Function

C1QB has several biochemical functions, for example, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C1QB itself. We selected most functions C1QB had, and list some proteins which have the same functions with C1QB. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein PARVA; WBP1; PAM16; COMP; NUMBL; ISL1; LINGO1; GTF2A1; CREM; MFF
Function protein homodimerization activity
Related Protein STOM; TIRAP; RRAGA; SP100; ACTN1; SLC4A1; IZUMO1; MSH2; PDE2A; GDNF

Interacting Protein

C1QB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C1QB here. Most of them are supplied by our site. Hope this information will be useful for your research of C1QB.
C1QA; RELA; q7chk1_yerpe; sbcD; treC; q81sh2_bacan; EDA2R

C1QB Related Articles

Yuan, HY; Chen, R; et al. Crystallization and preliminary crystallographic studies of the complement 1qA globular domain from zebrafish, Dare-C1qAgD. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 70:911-914(2014).
Nagano, F; Kaneko, T; et al. Gram-positive bacteria as an antigen topically applied into gingival sulcus of immunized rat accelerates periodontal destruction. JOURNAL OF PERIODONTAL RESEARCH 48:420-427(2013).