CACNA1C Protein, Calcium Channel, Voltage-Dependent, L Type, Alpha 1C Subunit


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Official Full Name Calcium Channel, Voltage-Dependent, L Type, Alpha 1C Subunit
Background Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. Specifically, Cav1.2 is a cardiac L-type calcium channel and is important for excitation and contraction of the heart. It may be associated with a variant of Long QT syndrome called Timothy’s syndrome and also with Brugada syndrome. Some references suggest it is related to bipolar disease as well.
Synonyms CACNA1C; Cav1.2 Calcium Channel; calcium channel, voltage-dependent, L type, alpha 1C subunit; TS; CACH2; CACN2; CaV1.2; CCHL1A1; CACNL1A1; MGC120730; voltage-dependent L-type calcium channel subunit alpha-1C; DHPR, alpha-1 subunit; calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit; calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*; Voltage-gated calcium channel subunit alpha Cav1.2; OTTHUMP00000196730; OTTHUMP00000196731; OTTHUMP00000196732; OTTHUMP00000196733; OTTHUMP00000196734; OTTHUMP00000196735; OTTHUMP00000196736; OTTHUMP00000196737; OTTHUMP00000196738; OTTHUMP00000196739; OTTHUMP00000196740; OTTHUMP00000196741; OTTHUMP00000196742; OTTHUMP00000196743; OTTHUMP00000196744; OTTHUMP00000196745; OTTHUMP00000196746; OTTHUMP00000196747; OTTHUMP00000196748; OTTHUMP00000196749; OTTHUMP00000196750; OTTHUMP00000196751; OTTHUMP00000238277; OTTHUMP00000238278; OTTHUMP00000238279
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CACNA1C-0264H Recombinant Human CACNA1C Protein, GST-Tagged Wheat Germ GST
    Mouse Cacna1c-1423M Recombinant Mouse Cacna1c protein, His & T7-tagged E.coli His/T7
    Zebrafish CACNA1C-9399Z Recombinant Zebrafish CACNA1C Mammalian Cell His

    CACNA1C involved in several pathways and played different roles in them. We selected most pathways CACNA1C participated on our site, such as MAPK signaling pathway, Calcium signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNA1C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway PRKACBA; FGF1A; CD14; RPS6KAL; RAC1B; HSPA1L; MAPK1; NTF4; JUND; CACNA1H
    Calcium signaling pathway ADCY1B; SPHK1; TACR1; ATP2A1; ADRB2B; TNNC1A; ADRB3A; SLC25A31; PLCD4; NOS1
    Cardiac muscle contraction TPM4A; ATP2A2; COX5A; ATP1A1; MYH15; ACTC1; ATP1B3A; COX7A2L; UQCRFS1; CACNG8
    Adrenergic signaling in cardiomyocytes GNAS; CALM1A; MAPK12A; ATP1B3A; TPMA; PIK3CD; ADRA1B; CACNA2D1A; CACNB1; CACNB3
    Vascular smooth muscle contraction PLA2G4A; NPR1; MYLK; ARHGEF11; PRKACG; MAPK1; CALM1; RHOAD; MLCK2; ROCK2A
    GnRH signaling pathway PLD1A; MAP2K4; ATF4; GNA11; CALM3A; MAP2K2A; MMP2; CALM1A; PRKACAB; CACNA1SB

    CACNA1C has several biochemical functions, for example, calcium channel activity, high voltage-gated calcium channel activity, ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNA1C itself. We selected most functions CACNA1C had, and list some proteins which have the same functions with CACNA1C. You can find most of the proteins on our site.

    Function Related Protein
    calcium channel activity GRIN2A; PSEN1; CACNG7A; TMEM37; TRPN1; MCU; TRPC4A; TRPM4; TRPC1; CHRNA10
    high voltage-gated calcium channel activity CACNA1BA; CACNA1SB; CACNB3A; CACNB4A; CACNB4B; CACNB2B; CACNA1DA; CACNB1; CACNB3; CACNA1C
    ion channel activity CHRNB3A; TRPC6A; TPC3; GRIN1B; P2RX3A; TRPC7B; CACNA1DA; SCNN1G; KCNC3B; CNGA4
    voltage-gated calcium channel activity CATSPER1; CACNG6; CACNA1C; CALHM1; OPRM1; CACNA1BA; CACNB4A; NCS1; PKD2; GAS6
    voltage-gated ion channel activity KCNS3B; KCNJ1A.3; KCNV2B; KCNJ16; KCNJ1A.4; KCNC1B; CX35B; KCNK7; CLIC5B; KCNC2

    CACNA1C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNA1C here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNA1C.

    Wenzel, K; Haase, H; et al. Potential Relevance of alpha(1)-Adrenergic Receptor Autoantibodies in Refractory Hypertension. PLOS ONE 3:-(2008).

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