CACNA1H Protein, calcium channel, voltage-dependent, T type, alpha 1H subunit

CACNA1H

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CACNA1H

Official Full Name calcium channel, voltage-dependent, T type, alpha 1H subunit
Background Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells and their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. Cav3.2 is a protein which in humans is encoded by the CACNA1H gene. Studies suggest certain mutations in this gene lead to childhood absence epilepsy. Studies also suggest that the up-regulations of Cav3.2 may participate in the progession of prostate cancer toward an androgen-independent stage.
Synonyms CACNA1H; calcium channel, voltage-dependent, T type, alpha 1H subunit; voltage-dependent T-type calcium channel subunit alpha-1H; Cav3.2; voltage-gated calcium channel alpha subunit Cav3.2; voltage-gated calcium channel alpha subunit CavT.2; voltage-gated
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    • GST
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CACNA1H-26604TH Recombinant Human CACNA1H, His-tagged E.coli His
    Mouse Cacna1h-1424M Recombinant Mouse Cacna1h protein, His & GST-tagged E.coli His/GST
    Rat CACNA1H-1064R Recombinant Rat CACNA1H Protein Mammalian Cell His

    CACNA1H involved in several pathways and played different roles in them. We selected most pathways CACNA1H participated on our site, such as MAPK signaling pathway, Calcium signaling pathway, Circadian entrainment, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNA1H were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway PLA2G4AA; Fgf15; TRP53; RPS6KA3; MAP2K4B; RRAS; HSP70; LAMTOR3; RAF1; PRKCA
    Calcium signaling pathway NOS1; GNA11A; STIM1; PLCB4; ITPR1; SLC8A4A; P2RX3B; PDE1C; ADRA1B; ADRa1A
    Circadian entrainment GNAI3; MAPK3; CALML5; GRIA4; GNAQ; GNG8; KCNJ6; PLCB4; PLCB2; PER2
    Aldosterone synthesis and secretion KCNK3; PLCB4; CREB3L2; CACNA1H; PLCB1; ATF6B; ATF4; ITPR2; CALML3; AGTR1A

    CACNA1H has several biochemical functions, for example, low voltage-gated calcium channel activity, metal ion binding, scaffold protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNA1H itself. We selected most functions CACNA1H had, and list some proteins which have the same functions with CACNA1H. You can find most of the proteins on our site.

    Function Related Protein
    low voltage-gated calcium channel activity CACNA1G; CACNA1H
    metal ion binding FTR50; ZFP74; CBS; U2AF1L4; HAGHL; BMI1A; ZNF193; PRDM16; GEN1; ETFDH
    scaffold protein binding NCK2; IKBKB; CACNA1H; ATP2B4; MAPK3; GRID2; KCNA5; PDE4D; NLGN3; SHANK3

    CACNA1H has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNA1H here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNA1H.

    PPP3CB; MAPK15

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