CACNG4
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Official Full Name
calcium channel, voltage-dependent, gamma subunit 4
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Overview
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. -
Synonyms
CACNG4; calcium channel, voltage-dependent, gamma subunit 4; voltage-dependent calcium channel gamma-4 subunit; MGC11138; MGC24983; Neuronal voltage gated calcium channel gamma 4 subunit; Voltage dependent calcium channel gamma 4 subunit; TARP gamma-4; transmembrane AMPAR regulatory protein gamma-4; neuronal voltage-gated calcium channel gamma-4 subunit;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Homo sapiens (Human)
- Human
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Involved Pathway
- Protein Function
- Interacting Protein
- CACNG4 Related Articles
CACNG4 involved in several pathways and played different roles in them. We selected most pathways CACNG4 participated on our site, such as MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNG4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | MAPK7;CACNA2D2;GADD45B;CACNG7;IKBKG;PAK2A;MAP3K3;MOS;FGF4 |
| Cardiac muscle contraction | UQCRQ;ATP1B1A;COX7B2;TPM4B;ATP1A1A.1;MYL2B;CACNG3;MYH7;COX5A |
| Adrenergic signaling in cardiomyocytes | PIK3R3A;PPP2R3C;PPP2R2C;PIK3R3B;ACTC1B;AGTR1B;MYH15;TNNT2A;TNNC1 |
| Oxytocin signaling pathway | PIK3R2;KRAS;PRKAA2;PIK3R1;CALM1;GUCY1B3;MYLK4;PPP3CC;CACNG1 |
| Hypertrophic cardiomyopathy (HCM) | CACNA2D2;TPM2;CACNG1;RYR2;PRKAA2;ITGA9;SGCB;SGCD;DAG1 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | DSG2;ACTN3;ACTN4;ATP2A2;ITGA10;CACNB4;SLC8A1;DMD;ITGA1 |
| Dilated cardiomyopathy | CACNG6;CACNG3;CACNB4;CACNB2;ACTC1;TPM3;CACNA2D2;TPM1;PRKACB |
CACNG4 has several biochemical functions, for example, channel regulator activity, voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNG4 itself. We selected most functions CACNG4 had, and list some proteins which have the same functions with CACNG4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| channel regulator activity | CACNG7A;CACNG8A;CACNG7;SLC9A3R2;CACNG2B;CACNG8;CACNG3;CNIH3;SNF8 |
| voltage-gated calcium channel activity | NCS1;TMC1;CACNG2A;CACNB2;CACNA2D4;ITGAV;GAS6;CACNG7;CACNB4A |
CACNG4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNG4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNG4.
- Q&As
- Reviews
Q&As (7)
Ask a questionSpecific methods, such as mass spectrometry, could be employed to detect potential post-translational modifications on CACNG4.
CACNG4 is mainly found in neural tissues, particularly within the brain.
Through its interaction, CACNG4 can influence the channel's gating dynamics, its cellular localization, and calcium ion permeation attributes.
Variations or dysfunctions in CACNG4 have been suggested in certain neurological conditions, though detailed research is necessary for specific links.
Genetic mutations within the CACNG4 gene can alter its modulatory role, impacting the function and behavior of associated calcium channels.
CACNG4 functions as an auxiliary subunit, modulating the activity, trafficking, and surface expression of voltage-gated calcium channels.
CACNG4 chiefly interacts with the alpha-1 subunit of calcium channels, and it might also associate with other channel-related proteins.
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