cacng4
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  • Official Full Name
  • calcium channel, voltage-dependent, gamma subunit 4
  • Background
  • The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit.
  • Synonyms
  • CACNG4; calcium channel, voltage-dependent, gamma subunit 4; voltage-dependent calcium channel gamma-4 subunit; MGC11138; MGC24983; Neuronal voltage gated calcium channel gamma 4 subunit; Voltage dependent calcium channel gamma 4 subunit; TARP gamma-4; transmembrane AMPAR regulatory protein gamma-4; neuronal voltage-gated calcium channel gamma-4 subunit
Cat.#:CACNG4-10644HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CACNG4, GST-tagged
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Cat.#:CACNG4-1073RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CACNG4 Protein
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Cat.#:CACNG4-5708CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CACNG4
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Involved Pathway

CACNG4 involved in several pathways and played different roles in them. We selected most pathways CACNG4 participated on our site, such as MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNG4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAP3K14; GADD45AA; PAK1; MAPK10; PRKCA; MAPK8A; RAP1AB; MAP4K4; HRASA; HSPA6
Cardiac muscle contraction
ATP1B2B; COX6C; COX7A2A; TPM4A; ATP1B3; UQCRH; ATP1B1; CACNB2A; UQCRB; MYH7
Adrenergic signaling in cardiomyocytes
AKT2L; CALM2; ATP1B3; VMHCL; CAMK2G; ADCY1A; PLCB2; AKT3A; SLC9A1; MYH15
Oxytocin signaling pathway
PRKAB2; KRAS; MAPK7; GNAI2; GNAI1; PPP1CB; CACNG6; OXTR; MAP2K5; CAMKK2
Hypertrophic cardiomyopathy (HCM)
DMD; TPM3; TPM1; ITGAV; IL6; CACNB2; TGFB1; Itga10&Itgb1; TNF; MYH7
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
ITGA4; DSG2; Itga10&Itgb1; CACNG4; LAMA2; ITGB1; RYR2; LEF1; DSP; CACNB1
Dilated cardiomyopathy
SGCG; ITGA4; PRKACG; MYL3; DES; Itga10&Itgb1; DAG1; CACNG2; RYR2; TTN

Protein Function

CACNG4 has several biochemical functions, for example, channel regulator activity, voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNG4 itself. We selected most functions CACNG4 had, and list some proteins which have the same functions with CACNG4. You can find most of the proteins on our site.
Function
Related Protein
Function channel regulator activity
Related Protein CNIH3; SLC9A3R2; SNF8; CACNG4; CACNG8; CACNG7; CACNG7A; CACNG3; CACNG8A; CACNG2A
Function voltage-gated calcium channel activity
Related Protein CACNG7; CATSPER1; CACNA2D4; CACNG4; CACNG2A; CACNA2D2; CACNG2; CACNG3; CACNB2B; CALHM1

CACNG4 Related Articles

Aoki, Y; Yamada, E; et al. Multiple actions of extracellular ATP and adenosine on calcium currents mediated by various purinoceptors in neurons of nucleus tractus solitarius. NEUROSCIENCE RESEARCH 50:245-255(2004).
Endoh, T; et al. Characterization of modulatory effects of postsynaptic metabotropic glutamate receptors on calcium currents in rat nucleus tractus solitarius. BRAIN RESEARCH 1024:212-224(2004).