|Official Full Name||caspase recruitment domain family, member 14|
|Background||The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encoding distinct isoforms have been reported.|
|Synonyms||CARD14; caspase recruitment domain family, member 14; caspase recruitment domain-containing protein 14; BIMP2; CARMA2; Bcl10 interacting MAGUK protein 2; Bimp 2; CARD 14; CARD containing MAGUK 2 protein; CARD containing MAGUK protein 2; Card maguk protein 2; Carma 2; Caspase recruitment domain containing protein 14; Caspase recruitment domain family member 14; Caspase recruitment domain protein 14; card-maguk protein 2; CARD-containing MAGUK 2 protein; CARD-containing MAGUK protein 2; bcl10-interacting maguk protein 2|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CARD14 involved in several pathways and played different roles in them. We selected most pathways CARD14 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CARD14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
CARD14 has several biochemical functions, for example, CARD domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CARD14 itself. We selected most functions CARD14 had, and list some proteins which have the same functions with CARD14. You can find most of the proteins on our site.
|CARD domain binding||MAVS; CARD9; RIPK2; C9orf89; CARD14; CARD11; NOD1|
CARD14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CARD14 here. Most of them are supplied by our site. Hope this information will be useful for your research of CARD14.
UBA1; UBE2N; UBE2V1; Map3k1; TRIP13