cbr3
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  • Official Full Name
  • carbonyl reductase 3
  • Background
  • Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols.The enzyme is classified as a monomeric NADPH-dependent oxidoreductase.CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.
  • Synonyms
  • CBR3; carbonyl reductase 3; carbonyl reductase [NADPH] 3; SDR21C2; short chain dehydrogenase/reductase family 21C; member 2; Carbonyl reductase (NADPH) 3; Carbonyl reductase (NADPH) 3 EC 1.1.1.184; CBR 3; CBR3_HUMAN; EC 1.1.1.184; hCBR3; NADPH dependent carbonyl reductase 3; NADPH-dependent carbonyl reductase 3; Short chain dehydrogenase/reductase family 21C member 2; OTTHUMP00000109012; short chain dehydrogenase/reductase family 21C, member 2
Cat.#:CBR3-0468HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CBR3 Protein, GST-Tagged
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Cat.#:CBR3-184HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Carbonyl Reductase 3, His-tagged
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Cat.#:CBR3-10763HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CBR3, GST-tagged
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Cat.#:CBR3-185HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CBR3, MYC/DDK-tagged
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Cat.#:CBR3-199HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CBR3, His tagged
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Cat.#:CBR3-26328THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CBR3, His-tagged
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Cat.#:CBR3-2788MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CBR3 Protein
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Cat.#:CBR3-644RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CBR3 Protein, His-tagged
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Cat.#:CBR3-7810HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CBR3 293 Cell Lysate
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Involved Pathway

CBR3 involved in several pathways and played different roles in them. We selected most pathways CBR3 participated on our site, such as Arachidonic acid metabolism, Metabolism of xenobiotics by cytochrome P, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonic acid metabolism
CYP2J5; CYP2B19; PLA2G4B; PTGES3; CYP4F22; ALOX5B.2; GPX1A; CYP4F18; PLA2G4C; CYP4A12A
Metabolism of xenobiotics by cytochrome P
UGT1AB; UGT1A6A; AKR7A2; GSTM7; UGT1A4; CYP2F2; UGT1A1; MGST3; DHDHL; CBR1
Metabolic pathways
ENOPH1; AMY2B; AKR1C4; PGAM1; MTAP; GNS; MECR; PNLIPRP3; GCSHA; ACOX3

Protein Function

CBR3 has several biochemical functions, for example, 3-keto sterol reductase activity, NADPH binding, carbonyl reductase (NADPH) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CBR3 itself. We selected most functions CBR3 had, and list some proteins which have the same functions with CBR3. You can find most of the proteins on our site.
Function
Related Protein
Function 3-keto sterol reductase activity
Related Protein CBR3; DHRS4; HSD17B7
Function NADPH binding
Related Protein FASN; QDPR; KCNAB1; DHFR; CBR3; GRHPR; DECR1; CBR4; MTRR; TP53I3
Function carbonyl reductase (NADPH) activity
Related Protein CBR1; DHRS4; DHRS2; CBR2; CBR3

Interacting Protein

CBR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBR3.
SGK1; USP3; ARIH2; RAB35; GABARAP; LDLR; CBR1; MKI67; RPS10; CCNL2; GABARAPL1