CBR4
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Official Full Name
carbonyl reductase 4 -
Overview
The heteroteramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro). -
Synonyms
CBR4;carbonyl reductase 4;carbonyl reductase family member 4;FLJ14431;SDR45C1;short chain dehydrogenase/reductase family 45C;member 1;3 oxoacyl [acyl carrier protein] reductase;3-oxoacyl-[acyl-carrier-protein] reductase;Carbonic reductase 4;CBR 4;CBR4_HUMAN;Quinone reductase CBR4;Short chain dehydrogenase/reductase family 45C member 1;short chain dehydrogenase/reductase family 45C, member 1
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Rhesus macaque
- Wheat Germ
- Mammalian Cells
- E.coli
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
Involved Pathway
CBR4 involved in several pathways and played different roles in them. We selected most pathways CBR4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CBR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CBR4 has several biochemical functions, for example, NAD(P)H dehydrogenase (quinone) activity,NADPH binding,NADPH dehydrogenase (quinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CBR4 itself. We selected most functions CBR4 had, and list some proteins which have the same functions with CBR4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADPH dehydrogenase (quinone) activity | NQO2 |
| NADPH binding | CRYZ,QDPR,DECR1,CBR3,DHFR,KCNAB1,TP53I3,MTRR,GRHPR,FASN |
| quinone binding | VKORC1L1,ETFDH,NDUFS2,HHIP,AOC3,HHIPL1,TP53I3,ABP1,SQRDL,AMOTL1 |
| NAD(P)H dehydrogenase (quinone) activity | NQO1 |
| protein binding | SIRT3,TRAF5,GPSM2,IGFBP3,ARL14,ARHGAP4,ITPR3,VMP1,AGO1,RICTOR |
Interacting Protein
CBR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBR4.
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