ccr10
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  • Official Full Name
  • chemokine (C-C motif) receptor 10
  • Background
  • Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]
  • Synonyms
  • CCR10; chemokine (C-C motif) receptor 10; GPR2; C-C chemokine receptor type 10; CCR-10; CC-CKR-10; C-C CKR-10; CC chemokine receptor 10; G protein-coupled receptor 2; G-protein coupled receptor 2;
Cat.#:CCR10-0687HTag:N/A
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCR10 Protein
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Cat.#:CCR10-0688HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCR10 Protein, GST-Tagged
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Cat.#:CCR10-3012MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CCR10 Protein
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Cat.#:CCR10-782ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CCR10
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Cat.#:CCR10-7697HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CCR10 293 Cell Lysate
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Cat.#:Kit-1148Tag:N/A
Source (Host):Species:
Product nameCCR10 Activated GPCR Internalization Assay Kit
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Cat.#:Kit-1149Tag:N/A
Source (Host):Species:
Product nameCCR10 U2OS β-Arrestin GPCR Assay Kit
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Cat.#:Kit-0926Tag:N/A
Source (Host):Species:
Product nameER Beta Competitor Assay Kit, Green
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Involved Pathway

CCR10 involved in several pathways and played different roles in them. We selected most pathways CCR10 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Intestinal i, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CCL27; CD40; CX3CL1; CSF2RA; TNFRSF12A; TNFSF9; IL28RA; TNFRSF10D; AMH; BMPR2A
Chemokine signaling pathway
GNG3; LYN; PIK3R5; GNG7; CXCL2; CXCL8; CCL18; NFKBIA; CCR3; GNB4
Intestinal i
BMA1; MADCAM1; LTBR; TNFRSF13B; TNFRSF17; HLA-DRA; HLA-DPA1; MHC2A; TGFB1A; HLA-DRB4
ne network for IgA production
HLA-DOB; HLA-DOA; TNFRSF17; MAP3K14; TGFB1; TNFSF13; CCL27B; TNFRSF13B; CXCL12B; MHC2DAB

Protein Function

CCR10 has several biochemical functions, for example, C-C chemokine receptor activity, G-protein coupled receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCR10 itself. We selected most functions CCR10 had, and list some proteins which have the same functions with CCR10. You can find most of the proteins on our site.
Function
Related Protein
Function C-C chemokine receptor activity
Related Protein CCBP2; CCR3; CCR1; CCR1L1; GPR75; CCR7; CCR8; CCR5; CCR6A; CCR9
Function G-protein coupled receptor activity
Related Protein OLFR147; TACR1A; GPR115; GNRHR2; TAAR8A; ADRA1BB; ZNF514; MC5RA; OLFR474; S1PR2

Interacting Protein

CCR10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR10 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR10.
FYN; NCK1; GRB2; PRRC2A

CCR10 Related Articles

Thomas, MA; Buelow, BJ; et al. Structure-Function Analysis of CCL28 in the Development of Post-viral Asthma. JOURNAL OF BIOLOGICAL CHEMISTRY 290:4528-4536(2015).
McKinnon, LR; Nyanga, B; et al. Early HIV-1 Infection Is Associated With Reduced Frequencies of Cervical Th17 Cells. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 68:6-12(2015).

CCR10 Related Gene Family

Chemokines Cytokines