CCT6A
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Official Full Name
chaperonin containing TCP1, subunit 6A (zeta 1) -
Overview
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. -
Synonyms
CCT6A;chaperonin containing TCP1, subunit 6A (zeta 1);CCT6;T-complex protein 1 subunit zeta;Cctz;HTR3;TCP20;TCPZ;TTCP20;Amino acid transport defect complementing;CCT zeta 1;CCT zeta;Chaperonin containing T complex subunit 6;Chaperonin containing TCP1 subunit 6A;Chaperonin containing TCP1 subunit 6A (zeta 1);Histidine transport regulator 3;MGC126214;MGC126215;MoDP 2;MoDP2;T complex protein 1 subunit zeta;T complex protein 1 zeta subunit;TCP 1 zeta;TCP1 zeta;T-complex protein 1, zeta subunit;amino acid transport defect-complementing;chaperonin containing T-complex subunit 6;acute morphine dependence-related protein 2;MoDP-2;CCT-zeta;CCT-zeta-1;TCP-1-zeta
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- Wheat Germ
- Mammalian Cells
- HEK293
- E.coli
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CCT6A-0715H | Recombinant Human CCT6A Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CCT6A-11438Z | Recombinant Zebrafish CCT6A | Mammalian Cells | Zebrafish | His |
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| CCT6A-1364C | Recombinant Chicken CCT6A | Mammalian Cells | Chicken | His |
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| CCT6A-3027M | Recombinant Mouse CCT6A Protein | Mammalian Cells | Mouse | His |
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| CCT6A-173HCL | Recombinant Human CCT6A lysate | HEK293 | Human | Non |
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| CCT6A-1430M | Recombinant Mouse CCT6A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| CCT6A-1430M-B | Recombinant Mouse CCT6A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CCT6A-2124H | Recombinant Human CCT6A Protein (2-531 aa), His-tagged | E.coli | Human | His | 2-531 aa |
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| CCT6A-3011H | Recombinant Human CCT6A Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| CCT6A-3052HF | Recombinant Full Length Human CCT6A Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 531 amino acids |
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| Cct6a-806M | Recombinant Mouse Cct6a Protein, MYC/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
CCT6A involved in several pathways and played different roles in them. We selected most pathways CCT6A participated on our site, such as Association of TriC/CCT with target proteins during biosynthesis,Chaperonin-mediated protein folding,Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCT6A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Folding of actin by CCT/TriC | CCT7,CCT8,CCT2,TCP1,CCT4,CCT3,CCT5 |
| Protein folding | FBXL5,FBXW2,FBXW9,TBCE,SERPINA7,FBXW4,TBCB,ARL2,PFDN2,TBCA |
| Prefoldin mediated transfer of substrate to CCT/TriC | PFDN5,PFDN6,PFDN4,VBP1,PFDN2,CCT7,PFDN1 |
| Association of TriC/CCT with target proteins during biosynthesis | NOP56,KIFC3,CCT7,CCT5,CCT4,FBXW2,CCT3,FBXW5,TCP1,FKBP9 |
| Chaperonin-mediated protein folding | VBP1,PFDN1,CCT8,TUBB4A,PFDN2,KIFC3,PFDN5,NOP56,CCT4,FBXL5 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | CCT7,CCT5,TCP1,CCT8,CCT2,VBP1,PFDN6,PFDN4,TUBA1B,TUBB4A |
| Metabolism of proteins | MUC21,WDR85,B3GALTL,SEC16B,FKBP9,FKBP14,MGAT4A,TIMM17A,TOMM6,EEF1B2 |
| Formation of tubulin folding intermediates by CCT/TriC | CCT4,TUBA1B,CCT8,CCT5,TUBB4A,TUBA3D,CCT7,CCT2,TCP1,TUBB4B |
Protein Function
CCT6A has several biochemical functions, for example, ATP binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCT6A itself. We selected most functions CCT6A had, and list some proteins which have the same functions with CCT6A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | STK11,TAE1,RTCB,Fert2,YARS,ABCF2,OASL,MYH1,STK35L,CDK11A |
| poly(A) RNA binding | RBMS1,SLC16A3,RIMS2,TPR,PCSK9,NHP2L1,EXOSC9,AATF,RPS4X,SF3B2 |
| protein binding | ZZZ3,KL,Ntng2,CALCOCO2,ETS2,HER11,HSP90AA1.2,DCPS,C17orf59,ZC3H14 |
| unfolded protein binding | DNAJA3B,SYVN1,CCT2,SIL1,HSP90AA1.2,CRYAB,CLGN,ERO1LB,CHAF1A,CLPX |
Interacting Protein
CCT6A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCT6A here. Most of them are supplied by our site. Hope this information will be useful for your research of CCT6A.
PPP4C;PPP2CB;PPP2CA;STRN3;ILK;STRN;JAK3;IGBP1
Resources
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References
- Wei, QQ; Zhu, GY; et al. Expression of CCT6A mRNA in chicken granulosa cells is regulated by progesterone. GENERAL AND COMPARATIVE ENDOCRINOLOGY 189:15-23(2013).
- Ferguson, JF; Meyer, NJ; et al. Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans. HUMAN MOLECULAR GENETICS 24:1801-1812(2015).
