|Official Full Name||cadherin 12, type 2 (N-cadherin 2)|
|Background||This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.|
|Synonyms||CDH12; cadherin 12, type 2 (N-cadherin 2); cadherin-12; Br cadherin; CDHB; Br-cadherin; N-cadherin 2; brain cadherin; brain-cadherin; neuronal cadherin 2; neural type cadherin 2; cadherin, neural type, 2; FLJ34857|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CDH12 involved in several pathways and played different roles in them. We selected most pathways CDH12 participated on our site, such as Adherens junctions interactions, Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Adherens junctions interactions||CDH24; CDH10A; ANG; JUP; CDH2; CDH7; CDH17; CDH8; CDH11; CADM2A|
|Cell junction organization||CDH12A; CD151; CADM2A; LIMS1; CLDN16; JUP; TESK1; CDH2; CDH4; CADM2B|
|Cell-Cell communication||PVRL1A; DST; JUP; CDH24; KIRREL2; INADL; CDH11; CLDN7; COL17A1A; LIMS1|
|Cell-cell junction organization||CDH8; CTNND1; CDH18; CDH24; CLDN20; F11R.2; CADM2; CLDN4; CDH9; ANG|
CDH12 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH12 itself. We selected most functions CDH12 had, and list some proteins which have the same functions with CDH12. You can find most of the proteins on our site.
|calcium ion binding||FREM1A; PCDH2G2; PCDH2AB5; PCDH2G29; SLC24A5; ACTN2B; KCNIP4; PKD2L2; RGN; PKD2|
CDH12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH12.