cdh12
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  • Official Full Name
  • cadherin 12, type 2 (N-cadherin 2)
  • Background
  • This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.
  • Synonyms
  • CDH12; cadherin 12, type 2 (N-cadherin 2); cadherin-12; Br cadherin; CDHB; Br-cadherin; N-cadherin 2; brain cadherin; brain-cadherin; neuronal cadherin 2; neural type cadherin 2; cadherin, neural type, 2; FLJ34857
Cat.#:CDH12-0973HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDH12 Protein, GST-Tagged
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Cat.#:CDH12-2230HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH12, His tagged
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Cat.#:CDH12-26803THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CDH12
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Cat.#:CDH12-3165MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CDH12 Protein
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Cat.#:CDH12-2625HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH12 cell lysate
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Involved Pathway

CDH12 involved in several pathways and played different roles in them. We selected most pathways CDH12 participated on our site, such as Adherens junctions interactions, Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adherens junctions interactions
CDH24; CDH8; CDH18A; CTNNB2; CTNNB1; CADM2B; CDH4; CDH3; CDH11; JUPA
Cell junction organization
CDH17; INADL; JUPA; CLDN4; CADM2; CD151; CLDN7; CLDN23; CDH13; CLDN16
Cell-Cell communication
DSCAML1; KIRRELB; KIRREL; CDH7; DCC; CLDN16; JUPA; COL17A1A; CLDN23; FERMT2
Cell-cell junction organization
CLDN16; CDH10A; INADL; CDH3; CADM2B; CADM2A; JUPA; JUP; CDH18A; CDH11

Protein Function

CDH12 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH12 itself. We selected most functions CDH12 had, and list some proteins which have the same functions with CDH12. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein PVALB3; SYT5B; DSG4; S100G; ANXA5B; MBL1; SULF2A; ANXA2B; ITSN1; ELTD1

Interacting Protein

CDH12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH12.
IGHG1